BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

216 related articles for article (PubMed ID: 23032264)

  • 1. cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation.
    Lau R; Niu MY; Pratt MA
    Cell Cycle; 2012 Nov; 11(21):4009-19. PubMed ID: 23032264
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis.
    Hu Y; Jin R; Gao M; Xu H; Zou S; Li X; Xing C; Wang Q; Wang H; Feng J; Hu M; Song L
    Oncogene; 2019 Jan; 38(5):731-746. PubMed ID: 30177839
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation.
    Xia M; Knezevic D; Tovar C; Huang B; Heimbrook DC; Vassilev LT
    Cell Cycle; 2008 Jun; 7(11):1604-12. PubMed ID: 18520179
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation.
    Seo SK; Hwang CS; Choe TB; Hong SI; Yi JY; Hwang SG; Lee HG; Oh ST; Lee YH; Park IC
    Oncotarget; 2015 Sep; 6(28):26528-40. PubMed ID: 25605253
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.
    Heo KS; Chang E; Takei Y; Le NT; Woo CH; Sullivan MA; Morrell C; Fujiwara K; Abe J
    Arterioscler Thromb Vasc Biol; 2013 Feb; 33(2):321-9. PubMed ID: 23202365
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression.
    Petersen SL; Peyton M; Minna JD; Wang X
    Proc Natl Acad Sci U S A; 2010 Jun; 107(26):11936-41. PubMed ID: 20547836
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
    Kurokawa M; Kim J; Geradts J; Matsuura K; Liu L; Ran X; Xia W; Ribar TJ; Henao R; Dewhirst MW; Kim WJ; Lucas JE; Wang S; Spector NL; Kornbluth S
    Sci Signal; 2013 May; 6(274):ra32. PubMed ID: 23652204
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of Mdm2 sensitizes human retinal pigment epithelial cells to apoptosis.
    Bhattacharya S; Ray RM; Chaum E; Johnson DA; Johnson LR
    Invest Ophthalmol Vis Sci; 2011 May; 52(6):3368-80. PubMed ID: 21345989
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3.
    Yang P; Chen W; Li X; Eilers G; He Q; Liu L; Wu Y; Wu Y; Yu W; Fletcher JA; Ou WB
    Oncotarget; 2016 May; 7(22):32652-63. PubMed ID: 27129163
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.
    Hu B; Gilkes DM; Farooqi B; Sebti SM; Chen J
    J Biol Chem; 2006 Nov; 281(44):33030-5. PubMed ID: 16905541
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression.
    Palani CD; Beck JF; Sonnemann J
    Invest New Drugs; 2012 Feb; 30(1):25-36. PubMed ID: 20680659
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells.
    Wade M; Li YC; Matani AS; Braun SM; Milanesi F; Rodewald LW; Wahl GM
    Oncogene; 2012 Nov; 31(45):4789-97. PubMed ID: 22266850
    [TBL] [Abstract][Full Text] [Related]  

  • 13. MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63.
    Gamble LD; Kees UR; Tweddle DA; Lunec J
    Oncogene; 2012 Feb; 31(6):752-63. PubMed ID: 21725357
    [TBL] [Abstract][Full Text] [Related]  

  • 14. D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.
    Choi S; Lew KL; Xiao H; Herman-Antosiewicz A; Xiao D; Brown CK; Singh SV
    Carcinogenesis; 2007 Jan; 28(1):151-62. PubMed ID: 16920735
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
    Darding M; Feltham R; Tenev T; Bianchi K; Benetatos C; Silke J; Meier P
    Cell Death Differ; 2011 Aug; 18(8):1376-86. PubMed ID: 21331077
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency.
    Cheng L; Zhou Z; Flesken-Nikitin A; Toshkov IA; Wang W; Camps J; Ried T; Nikitin AY
    Oncogene; 2010 Oct; 29(42):5700-11. PubMed ID: 20676140
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.
    Sriraman A; Radovanovic M; Wienken M; Najafova Z; Li Y; Dobbelstein M
    Oncotarget; 2016 May; 7(22):31623-38. PubMed ID: 27183917
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability.
    Huart AS; MacLaine NJ; Meek DW; Hupp TR
    J Biol Chem; 2009 Nov; 284(47):32384-94. PubMed ID: 19759023
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill.
    Xie X; He G; Siddik ZH
    Mol Pharmacol; 2020 Apr; 97(4):237-249. PubMed ID: 32063580
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1.
    Ray RM; Bhattacharya S; Johnson LR
    Apoptosis; 2011 Jan; 16(1):35-44. PubMed ID: 20812030
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.