BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 23043551)

  • 1. Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.
    Zheng W; Ibáñez G; Wu H; Blum G; Zeng H; Dong A; Li F; Hajian T; Allali-Hassani A; Amaya MF; Siarheyeva A; Yu W; Brown PJ; Schapira M; Vedadi M; Min J; Luo M
    J Am Chem Soc; 2012 Oct; 134(43):18004-14. PubMed ID: 23043551
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors.
    Kashyap S; Sandler J; Peters U; Martinez EJ; Kapoor TM
    Bioorg Med Chem; 2014 Apr; 22(7):2253-60. PubMed ID: 24650704
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors.
    Liu Q; Cai X; Yang D; Chen Y; Wang Y; Shao L; Wang MW
    Bioorg Med Chem; 2017 Sep; 25(17):4579-4594. PubMed ID: 28739157
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.
    Taylor AP; Swewczyk M; Kennedy S; Trush VV; Wu H; Zeng H; Dong A; Ferreira de Freitas R; Tatlock J; Kumpf RA; Wythes M; Casimiro-Garcia A; Denny RA; Parikh MD; Li F; Barsyte-Lovejoy D; Schapira M; Vedadi M; Brown PJ; Arrowsmith CH; Owen DR
    J Med Chem; 2019 Sep; 62(17):7669-7683. PubMed ID: 31415173
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hit identification of SMYD3 enzyme inhibitors using structure-based pharmacophore modeling.
    Alnabulsi SM; Al-Shar'i NA
    Future Med Chem; 2019 May; 11(10):1107-1117. PubMed ID: 31280673
    [No Abstract]   [Full Text] [Related]  

  • 6. Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors.
    Milite C; Feoli A; Viviano M; Rescigno D; Mai A; Castellano S; Sbardella G
    ChemMedChem; 2016 Aug; 11(16):1680-5. PubMed ID: 27411844
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
    Butler KV; Ma A; Yu W; Li F; Tempel W; Babault N; Pittella-Silva F; Shao J; Wang J; Luo M; Vedadi M; Brown PJ; Arrowsmith CH; Jin J
    J Med Chem; 2016 Nov; 59(21):9881-9889. PubMed ID: 27804297
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
    Tisi D; Chiarparin E; Tamanini E; Pathuri P; Coyle JE; Hold A; Holding FP; Amin N; Martin AC; Rich SJ; Berdini V; Yon J; Acklam P; Burke R; Drouin L; Harmer JE; Jeganathan F; van Montfort RL; Newbatt Y; Tortorici M; Westlake M; Wood A; Hoelder S; Heightman TD
    ACS Chem Biol; 2016 Nov; 11(11):3093-3105. PubMed ID: 27571355
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L.
    Anglin JL; Deng L; Yao Y; Cai G; Liu Z; Jiang H; Cheng G; Chen P; Dong S; Song Y
    J Med Chem; 2012 Sep; 55(18):8066-74. PubMed ID: 22924785
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Recent Advances in Chemical Tools for the Regulation and Study of Protein Lysine Methyltransferases.
    Hirano T; Mori S; Kagechika H
    Chem Rec; 2018 Dec; 18(12):1745-1759. PubMed ID: 30079624
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases.
    Guitot K; Drujon T; Burlina F; Sagan S; Beaupierre S; Pamlard O; Dodd RH; Guillou C; Bolbach G; Sachon E; Guianvarc'h D
    Anal Bioanal Chem; 2017 Jun; 409(15):3767-3777. PubMed ID: 28389916
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of a chemical probe for PRDM9.
    Allali-Hassani A; Szewczyk MM; Ivanochko D; Organ SL; Bok J; Ho JSY; Gay FPH; Li F; Blazer L; Eram MS; Halabelian L; Dilworth D; Luciani GM; Lima-Fernandes E; Wu Q; Loppnau P; Palmer N; Talib SZA; Brown PJ; Schapira M; Kaldis P; O'Hagan RC; Guccione E; Barsyte-Lovejoy D; Arrowsmith CH; Sanders JM; Kattar SD; Bennett DJ; Nicholson B; Vedadi M
    Nat Commun; 2019 Dec; 10(1):5759. PubMed ID: 31848333
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends.
    Fabini E; Manoni E; Ferroni C; Rio AD; Bartolini M
    Future Med Chem; 2019 Apr; 11(8):901-921. PubMed ID: 30998113
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases.
    Hintzen JCJ; Merx J; Maas MN; Langens SGHA; White PB; Boltje TJ; Mecinović J
    Org Biomol Chem; 2021 Dec; 20(1):173-181. PubMed ID: 34877957
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II).
    Lenstra DC; Al Temimi AHK; Mecinović J
    Bioorg Med Chem Lett; 2018 Apr; 28(7):1234-1238. PubMed ID: 29519735
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Protein Lysine Methyltransferases Inhibitors.
    Li Y; Ding L; Ren S; Zhang W; Rao GW
    Curr Med Chem; 2023; 30(27):3060-3089. PubMed ID: 36043747
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma.
    Yuan Y; Wang Q; Paulk J; Kubicek S; Kemp MM; Adams DJ; Shamji AF; Wagner BK; Schreiber SL
    ACS Chem Biol; 2012 Jul; 7(7):1152-7. PubMed ID: 22536950
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.
    Cowen SD; Russell D; Dakin LA; Chen H; Larsen NA; Godin R; Throner S; Zheng X; Molina A; Wu J; Cheung T; Howard T; Garcia-Arenas R; Keen N; Pendleton CS; Pietenpol JA; Ferguson AD
    J Med Chem; 2016 Dec; 59(24):11079-11097. PubMed ID: 28002961
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5.
    Chen WL; Li DD; Wang ZH; Xu XL; Zhang XJ; Jiang ZY; Guo XK; You QD
    Bioorg Chem; 2018 Feb; 76():380-385. PubMed ID: 29241110
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2.
    Eggert E; Hillig RC; Koehr S; Stöckigt D; Weiske J; Barak N; Mowat J; Brumby T; Christ CD; Ter Laak A; Lang T; Fernandez-Montalvan AE; Badock V; Weinmann H; Hartung IV; Barsyte-Lovejoy D; Szewczyk M; Kennedy S; Li F; Vedadi M; Brown PJ; Santhakumar V; Arrowsmith CH; Stellfeld T; Stresemann C
    J Med Chem; 2016 May; 59(10):4578-600. PubMed ID: 27075367
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.