166 related articles for article (PubMed ID: 23056920)
21. How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?
Plashkevych O; Li Q; Chattopadhyaya J
Mol Biosyst; 2017 May; 13(5):921-938. PubMed ID: 28352859
[TBL] [Abstract][Full Text] [Related]
22. Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.
Zhou C; Liu Y; Andaloussi M; Badgujar N; Plashkevych O; Chattopadhyaya J
J Org Chem; 2009 Jan; 74(1):118-34. PubMed ID: 19055352
[TBL] [Abstract][Full Text] [Related]
23. Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice.
Yamamoto T; Fujii N; Yasuhara H; Wada S; Wada F; Shigesada N; Harada-Shiba M; Obika S
Nucleic Acid Ther; 2014 Aug; 24(4):283-90. PubMed ID: 24758560
[TBL] [Abstract][Full Text] [Related]
24. Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides.
Wada F; Yamamoto T; Kobayashi T; Tachibana K; Ito KR; Hamasaki M; Kayaba Y; Terada C; Yamayoshi A; Obika S; Harada-Shiba M
Mol Ther Nucleic Acids; 2021 Dec; 26():957-969. PubMed ID: 34760338
[TBL] [Abstract][Full Text] [Related]
25. 2'-O,4'-C-Methylene-Bridged Nucleic Acids Stabilize Metal-Mediated Base Pairing in a DNA Duplex.
Nakagawa O; Fujii A; Kishimoto Y; Nakatsuji Y; Nozaki N; Obika S
Chembiochem; 2018 Nov; 19(22):2372-2379. PubMed ID: 30168891
[TBL] [Abstract][Full Text] [Related]
26. Down-regulation of VEGF mRNA expression by 2'-O,4'-C-ethylene-bridged nucleic acid (ENA) antisense oligonucleotides and investigation of non-target gene expression.
Morita K; Yamate K; Kurakata S; Abe K; Imanishi T; Koizumi M
Nucleic Acids Res Suppl; 2002; (2):99-100. PubMed ID: 12903124
[TBL] [Abstract][Full Text] [Related]
27. N-Methyl substituted 2',4'- BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization.
Miyashita K; Rahman SM; Seki S; Obika S; Imanishi T
Chem Commun (Camb); 2007 Sep; (36):3765-7. PubMed ID: 17851621
[TBL] [Abstract][Full Text] [Related]
28. Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.
Frieden M; Christensen SM; Mikkelsen ND; Rosenbohm C; Thrue CA; Westergaard M; Hansen HF; Ørum H; Koch T
Nucleic Acids Res; 2003 Nov; 31(21):6365-72. PubMed ID: 14576324
[TBL] [Abstract][Full Text] [Related]
29. 2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*.
Kishimoto Y; Nakagawa O; Fujii A; Yoshioka K; Nagata T; Yokota T; Hari Y; Obika S
Chemistry; 2021 Feb; 27(7):2427-2438. PubMed ID: 33280173
[TBL] [Abstract][Full Text] [Related]
30. Thermodynamic and kinetic characterization of duplex formation between 2'-O, 4'-C-methylene-modified oligoribonucleotides, DNA and RNA.
Christensen U
Biosci Rep; 2007 Dec; 27(6):327-33. PubMed ID: 17592767
[TBL] [Abstract][Full Text] [Related]
31. Locked nucleic acid oligonucleotides: the next generation of antisense agents?
Grünweller A; Hartmann RK
BioDrugs; 2007; 21(4):235-43. PubMed ID: 17628121
[TBL] [Abstract][Full Text] [Related]
32. Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides.
Seth PP; Allerson CR; Siwkowski A; Vasquez G; Berdeja A; Migawa MT; Gaus H; Prakash TP; Bhat B; Swayze EE
J Med Chem; 2010 Dec; 53(23):8309-18. PubMed ID: 21058707
[TBL] [Abstract][Full Text] [Related]
33. Synthesis and biophysical properties of 5'-thio-2',4'-BNA/LNA oligonucleotide.
Islam MA; Fujisaka A; Mori S; Ito KR; Yamaguchi T; Obika S
Bioorg Med Chem; 2018 Jul; 26(12):3634-3638. PubMed ID: 29886084
[TBL] [Abstract][Full Text] [Related]
34. Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2'-alkoxy modified oligonucleotides.
Honcharenko D; Barman J; Varghese OP; Chattopadhyaya J
Biochemistry; 2007 May; 46(19):5635-46. PubMed ID: 17411072
[TBL] [Abstract][Full Text] [Related]
35. Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle.
Hara T; Kodama T; Takegaki Y; Morihiro K; Ito KR; Obika S
J Org Chem; 2017 Jan; 82(1):25-36. PubMed ID: 27958739
[TBL] [Abstract][Full Text] [Related]
36. Novel strategy of liver cancer treatment with modified antisense oligonucleotides targeting human vasohibin-2.
Horie S; Suzuki Y; Yamamoto T; Obika S; Mohri K; Kiyota C; Ren Q; Warashina S; Wada Y; Watanabe Y; Mukai H; Sato Y
Cancer Sci; 2023 Sep; 114(9):3740-3749. PubMed ID: 37430466
[TBL] [Abstract][Full Text] [Related]
37. Five- and six-membered conformationally locked 2',4'-carbocyclic ribo-thymidines: synthesis, structure, and biochemical studies.
Srivastava P; Barman J; Pathmasiri W; Plashkevych O; Wenska M; Chattopadhyaya J
J Am Chem Soc; 2007 Jul; 129(26):8362-79. PubMed ID: 17552524
[TBL] [Abstract][Full Text] [Related]
38. Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.
Zhou C; Plashkevych O; Chattopadhyaya J
J Org Chem; 2009 May; 74(9):3248-65. PubMed ID: 19348480
[TBL] [Abstract][Full Text] [Related]
39. Downregulation of p21(WAF1/CIP1) and estrogen receptor alpha in MCF-7 cells by antisense oligonucleotides containing locked nucleic acid (LNA).
Jepsen JS; Pfundheller HM; Lykkesfeldt AE
Oligonucleotides; 2004; 14(2):147-56. PubMed ID: 15294077
[TBL] [Abstract][Full Text] [Related]
40. An Investigation into the Potential of Targeting
Goddard LR; Mardle CE; Gneid H; Ball CG; Gowers DM; Atkins HS; Butt LE; Watts JK; Vincent HA; Callaghan AJ
Molecules; 2021 Jun; 26(11):. PubMed ID: 34200016
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]