165 related articles for article (PubMed ID: 23058106)
1. Benzimidazole inhibitors of the protein kinase CHK2: clarification of the binding mode by flexible side chain docking and protein-ligand crystallography.
Matijssen C; Silva-Santisteban MC; Westwood IM; Siddique S; Choi V; Sheldrake P; van Montfort RL; Blagg J
Bioorg Med Chem; 2012 Nov; 20(22):6630-9. PubMed ID: 23058106
[TBL] [Abstract][Full Text] [Related]
2. X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket.
Lountos GT; Jobson AG; Tropea JE; Self CR; Zhang G; Pommier Y; Shoemaker RH; Waugh DS
FEBS Lett; 2011 Oct; 585(20):3245-9. PubMed ID: 21907711
[TBL] [Abstract][Full Text] [Related]
3. Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles.
Arienti KL; Brunmark A; Axe FU; McClure K; Lee A; Blevitt J; Neff DK; Huang L; Crawford S; Pandit CR; Karlsson L; Breitenbucher JG
J Med Chem; 2005 Mar; 48(6):1873-85. PubMed ID: 15771432
[TBL] [Abstract][Full Text] [Related]
4. Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor.
Lountos GT; Tropea JE; Zhang D; Jobson AG; Pommier Y; Shoemaker RH; Waugh DS
Protein Sci; 2009 Jan; 18(1):92-100. PubMed ID: 19177354
[TBL] [Abstract][Full Text] [Related]
5. Alternative binding modes of an inhibitor to two different kinases.
De Moliner E; Brown NR; Johnson LN
Eur J Biochem; 2003 Aug; 270(15):3174-81. PubMed ID: 12869192
[TBL] [Abstract][Full Text] [Related]
6. Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy.
Lountos GT; Jobson AG; Tropea JE; Self CR; Zhang G; Pommier Y; Shoemaker RH; Waugh DS
J Struct Biol; 2011 Dec; 176(3):292-301. PubMed ID: 21963792
[TBL] [Abstract][Full Text] [Related]
7. Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2.
Hilton S; Naud S; Caldwell JJ; Boxall K; Burns S; Anderson VE; Antoni L; Allen CE; Pearl LH; Oliver AW; Wynne Aherne G; Garrett MD; Collins I
Bioorg Med Chem; 2010 Jan; 18(2):707-18. PubMed ID: 20022510
[TBL] [Abstract][Full Text] [Related]
8. Novel non-benzimidazole chk2 kinase inhibitors.
McClure KJ; Huang L; Arienti KL; Axe FU; Brunmark A; Blevitt J; Breitenbucher JG
Bioorg Med Chem Lett; 2006 Apr; 16(7):1924-8. PubMed ID: 16442290
[TBL] [Abstract][Full Text] [Related]
9. Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors.
Taha M; Ismail NH; Imran S; Selvaraj M; Rashwan H; Farhanah FU; Rahim F; Kesavanarayanan KS; Ali M
Bioorg Chem; 2015 Aug; 61():36-44. PubMed ID: 26073618
[TBL] [Abstract][Full Text] [Related]
10. Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2.
Silva-Santisteban MC; Westwood IM; Boxall K; Brown N; Peacock S; McAndrew C; Barrie E; Richards M; Mirza A; Oliver AW; Burke R; Hoelder S; Jones K; Aherne GW; Blagg J; Collins I; Garrett MD; van Montfort RL
PLoS One; 2013; 8(6):e65689. PubMed ID: 23776527
[TBL] [Abstract][Full Text] [Related]
11. Benzimidazole inhibitors of protein kinase CK2 potently inhibit the activity of atypical protein kinase Rio1.
Kubiński K; Masłyk M; Orzeszko A
Mol Cell Biochem; 2017 Feb; 426(1-2):195-203. PubMed ID: 27909846
[TBL] [Abstract][Full Text] [Related]
12. Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs.
Galal SA; Abdelsamie AS; Shouman SA; Attia YM; Ali HI; Tabll A; El-Shenawy R; El Abd YS; Ali MM; Mahmoud AE; Abdel-Halim AH; Fyiad AA; Girgis AS; El-Diwani HI
Eur J Med Chem; 2017 Jul; 134():392-405. PubMed ID: 28433679
[TBL] [Abstract][Full Text] [Related]
13. Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors.
Galal SA; Khairat SHM; Ali HI; Shouman SA; Attia YM; Ali MM; Mahmoud AE; Abdel-Halim AH; Fyiad AA; Tabll A; El-Shenawy R; El Abd YS; Ramdan R; El Diwani HI
Eur J Med Chem; 2018 Jan; 144():859-873. PubMed ID: 29316526
[TBL] [Abstract][Full Text] [Related]
14. Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship.
Solanki S; Innocenti P; Mas-Droux C; Boxall K; Barillari C; van Montfort RL; Aherne GW; Bayliss R; Hoelder S
J Med Chem; 2011 Mar; 54(6):1626-39. PubMed ID: 21366329
[TBL] [Abstract][Full Text] [Related]
15. Benzimidazole derivatives as kinase inhibitors.
Garuti L; Roberti M; Bottegoni G
Curr Med Chem; 2014; 21(20):2284-98. PubMed ID: 24533813
[TBL] [Abstract][Full Text] [Related]
16. CDOCKER and λ-dynamics for prospective prediction in D₃R Grand Challenge 2.
Ding X; Hayes RL; Vilseck JZ; Charles MK; Brooks CL
J Comput Aided Mol Des; 2018 Jan; 32(1):89-102. PubMed ID: 28884249
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting the cannabinoid receptor type 1.
Espinosa-Bustos C; Lagos CF; Romero-Parra J; Zárate AM; Mella-Raipán J; Pessoa-Mahana H; Recabarren-Gajardo G; Iturriaga-Vásquez P; Tapia RA; Pessoa-Mahana CD
Arch Pharm (Weinheim); 2015 Feb; 348(2):81-8. PubMed ID: 25641513
[TBL] [Abstract][Full Text] [Related]
18. Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
Jacobs MD; Black J; Futer O; Swenson L; Hare B; Fleming M; Saxena K
J Biol Chem; 2005 Apr; 280(14):13728-34. PubMed ID: 15657054
[TBL] [Abstract][Full Text] [Related]
19. Ligand-induced conformational changes: improved predictions of ligand binding conformations and affinities.
Frimurer TM; Peters GH; Iversen LF; Andersen HS; Møller NP; Olsen OH
Biophys J; 2003 Apr; 84(4):2273-81. PubMed ID: 12668436
[TBL] [Abstract][Full Text] [Related]
20. 2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2.
Neff DK; Lee-Dutra A; Blevitt JM; Axe FU; Hack MD; Buma JC; Rynberg R; Brunmark A; Karlsson L; Breitenbucher JG
Bioorg Med Chem Lett; 2007 Dec; 17(23):6467-71. PubMed ID: 17937984
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
