These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 23079492)

  • 1. Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity.
    Pirrie L; McCarthy AR; Major LL; Morkūnaitė V; Zubrienė A; Matulis D; Lain S; Lebl T; Westwood NJ
    Molecules; 2012 Oct; 17(10):12206-24. PubMed ID: 23079492
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
    Suzuki T; Khan MN; Sawada H; Imai E; Itoh Y; Yamatsuta K; Tokuda N; Takeuchi J; Seko T; Nakagawa H; Miyata N
    J Med Chem; 2012 Jun; 55(12):5760-73. PubMed ID: 22642300
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner.
    McCarthy AR; Sachweh MC; Higgins M; Campbell J; Drummond CJ; van Leeuwen IM; Pirrie L; Ladds MJ; Westwood NJ; Laín S
    Mol Cancer Ther; 2013 Apr; 12(4):352-60. PubMed ID: 23322738
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells.
    Sunami Y; Araki M; Hironaka Y; Morishita S; Kobayashi M; Liew EL; Edahiro Y; Tsutsui M; Ohsaka A; Komatsu N
    PLoS One; 2013; 8(2):e57633. PubMed ID: 23460888
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 3-(N-arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2).
    Choi SH; Quinti L; Kazantsev AG; Silverman RB
    Bioorg Med Chem Lett; 2012 Apr; 22(8):2789-93. PubMed ID: 22446090
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD
    Mellini P; Itoh Y; Elboray EE; Tsumoto H; Li Y; Suzuki M; Takahashi Y; Tojo T; Kurohara T; Miyake Y; Miura Y; Kitao Y; Kotoku M; Iida T; Suzuki T
    J Med Chem; 2019 Jun; 62(12):5844-5862. PubMed ID: 31144814
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
    Sakai T; Matsumoto Y; Ishikawa M; Sugita K; Hashimoto Y; Wakai N; Kitao A; Morishita E; Toyoshima C; Hayashi T; Akiyama T
    Bioorg Med Chem; 2015 Jan; 23(2):328-39. PubMed ID: 25515955
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
    Khanfar MA; Quinti L; Wang H; Choi SH; Kazantsev AG; Silverman RB
    Eur J Med Chem; 2014 Apr; 76():414-26. PubMed ID: 24602787
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of novel SIRT2-selective inhibitors using a click chemistry approach.
    Tatum PR; Sawada H; Ota Y; Itoh Y; Zhan P; Ieda N; Nakagawa H; Miyata N; Suzuki T
    Bioorg Med Chem Lett; 2014 Apr; 24(8):1871-4. PubMed ID: 24675380
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
    Cui H; Kamal Z; Ai T; Xu Y; More SS; Wilson DJ; Chen L
    J Med Chem; 2014 Oct; 57(20):8340-57. PubMed ID: 25275824
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities.
    Spiegelman NA; Price IR; Jing H; Wang M; Yang M; Cao J; Hong JY; Zhang X; Aramsangtienchai P; Sadhukhan S; Lin H
    ChemMedChem; 2018 Sep; 13(18):1890-1894. PubMed ID: 30058233
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells.
    Jin Y; Cao Q; Chen C; Du X; Jin B; Pan J
    BMC Cancer; 2015 Apr; 15():226. PubMed ID: 25884180
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Unexpected small molecules as novel SIRT2 suicide inhibitors.
    Chen X; Zou Y; Wang J; Cao Z; Liu J; Li Y; Zhao Y; He B
    Bioorg Med Chem; 2020 Mar; 28(6):115353. PubMed ID: 32061485
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells.
    Ueno T; Endo S; Saito R; Hirose M; Hirai S; Suzuki H; Yamato K; Hyodo I
    Oncol Res; 2013; 21(3):155-64. PubMed ID: 24512730
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT.
    Yagci S; Gozelle M; Kaya SG; Ozkan Y; Aksel AB; Bakar-Ates F; Dundar Y; Eren G
    Bioorg Med Chem; 2021 Jan; 30():115961. PubMed ID: 33360574
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020.
    Roshdy E; Mustafa M; Shaltout AE; Radwan MO; Ibrahim MAA; Soliman ME; Fujita M; Otsuka M; Ali TFS
    Eur J Med Chem; 2021 Nov; 224():113709. PubMed ID: 34303869
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as Sirt1/2 Inhibitor.
    Park JB
    PLoS One; 2016; 11(3):e0150392. PubMed ID: 26986569
    [TBL] [Abstract][Full Text] [Related]  

  • 18. High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
    Yu J; Wu Y; Yang P
    J Neurochem; 2016 May; 137(3):371-83. PubMed ID: 26896748
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.
    Therrien E; Larouche G; Nguyen N; Rahil J; Lemieux AM; Li Z; Fournel M; Yan TP; Landry AJ; Lefebvre S; Wang JJ; MacBeth K; Heise C; Nguyen A; Besterman JM; Déziel R; Wahhab A
    Bioorg Med Chem Lett; 2015 Jun; 25(12):2514-8. PubMed ID: 25971769
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
    Yang L; Ma X; Yuan C; He Y; Li L; Fang S; Xia W; He T; Qian S; Xu Z; Li G; Wang Z
    Eur J Med Chem; 2017 Jul; 134():230-241. PubMed ID: 28415012
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.