BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 23085173)

  • 1. Identification of structural determinants of ligand selectivity in 5-HT₂ receptor subtypes on the basis of protein-ligand interactions.
    Jang JW; Kim MS; Cho YS; Cho AE; Pae AN
    J Mol Graph Model; 2012 Sep; 38():342-53. PubMed ID: 23085173
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular modeling and docking studies of human 5-hydroxytryptamine 2A (5-HT2A) receptor for the identification of hotspots for ligand binding.
    Kanagarajadurai K; Malini M; Bhattacharya A; Panicker MM; Sowdhamini R
    Mol Biosyst; 2009 Dec; 5(12):1877-88. PubMed ID: 19763327
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors: direct and indirect effects on ligand affinity mediated by the same locus.
    Almaula N; Ebersole BJ; Ballesteros JA; Weinstein H; Sealfon SC
    Mol Pharmacol; 1996 Jul; 50(1):34-42. PubMed ID: 8700116
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.
    Fevig JM; Feng J; Rossi KA; Miller KJ; Wu G; Hung CP; Ung T; Malmstrom SE; Zhang G; Keim WJ; Cullen MJ; Rohrbach KW; Qu Q; Gan J; Pelleymounter MA; Robl JA
    Bioorg Med Chem Lett; 2013 Jan; 23(1):330-5. PubMed ID: 23177783
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Predictive in silico studies of human 5-hydroxytryptamine receptor subtype 2B (5-HT2B) and valvular heart disease.
    Reid TE; Kumar K; Wang XS
    Curr Top Med Chem; 2013; 13(11):1353-62. PubMed ID: 23675941
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 5-HT₂c receptor selectivity and structure-activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs.
    Jang JW; Baek JS; Choi GD; Park WK; Cho YS; Baek DJ; Pae AN
    Bioorg Med Chem Lett; 2012 Jan; 22(1):347-52. PubMed ID: 22153942
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling.
    Rashid M; Manivet P; Nishio H; Pratuangdejkul J; Rajab M; Ishiguro M; Launay JM; Nagatomo T
    Life Sci; 2003 May; 73(2):193-207. PubMed ID: 12738034
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Predicted structures and dynamics for agonists and antagonists bound to serotonin 5-HT2B and 5-HT2C receptors.
    Kim SK; Li Y; Abrol R; Heo J; Goddard WA
    J Chem Inf Model; 2011 Feb; 51(2):420-33. PubMed ID: 21299232
    [TBL] [Abstract][Full Text] [Related]  

  • 9. G protein- and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations.
    Isberg V; Balle T; Sander T; Jørgensen FS; Gloriam DE
    J Chem Inf Model; 2011 Feb; 51(2):315-25. PubMed ID: 21261291
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Position 5.46 of the serotonin 5-HT2A receptor contributes to a species-dependent variation for the 5-HT2C agonist (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: impact on selectivity and toxicological evaluation.
    Miller KJ; Wu GY; Varnes JG; Levesque P; Li J; Li D; Robl JA; Rossi KA; Wacker DA
    Mol Pharmacol; 2009 Dec; 76(6):1211-9. PubMed ID: 19767451
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular modelling of human 5-hydroxytryptamine receptor (5-HT2A) and virtual screening studies towards the identification of agonist and antagonist molecules.
    Gandhimathi A; Sowdhamini R
    J Biomol Struct Dyn; 2016 May; 34(5):952-70. PubMed ID: 26327576
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor.
    Setola V; Dukat M; Glennon RA; Roth BL
    Mol Pharmacol; 2005 Jul; 68(1):20-33. PubMed ID: 15831837
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens.
    Rickli A; Moning OD; Hoener MC; Liechti ME
    Eur Neuropsychopharmacol; 2016 Aug; 26(8):1327-37. PubMed ID: 27216487
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Detection of new biased agonists for the serotonin 5-HT2A receptor: modeling and experimental validation.
    Martí-Solano M; Iglesias A; de Fabritiis G; Sanz F; Brea J; Loza MI; Pastor M; Selent J
    Mol Pharmacol; 2015 Apr; 87(4):740-6. PubMed ID: 25661038
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.
    Cussac D; Boutet-Robinet E; Ailhaud MC; Newman-Tancredi A; Martel JC; Danty N; Rauly-Lestienne I
    Eur J Pharmacol; 2008 Oct; 594(1-3):32-8. PubMed ID: 18703043
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT(2C) agonists for the treatment of metabolic disorders.
    Tye H; Mueller SG; Prestle J; Scheuerer S; Schindler M; Nosse B; Prevost N; Brown CJ; Heifetz A; Moeller C; Pedret-Dunn A; Whittaker M
    Bioorg Med Chem Lett; 2011 Jan; 21(1):34-7. PubMed ID: 21146986
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Regulation of intraocular pressure in mice: structural analysis of dopaminergic and serotonergic systems in response to cabergoline.
    Platania CB; Leggio GM; Drago F; Salomone S; Bucolo C
    Biochem Pharmacol; 2013 Nov; 86(9):1347-56. PubMed ID: 23962442
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists.
    Bray JK; Goddard WA
    J Mol Graph Model; 2008 Aug; 27(1):66-81. PubMed ID: 18499489
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model.
    Renault N; Gohier A; Chavatte P; Farce A
    Eur J Med Chem; 2010 Nov; 45(11):5086-99. PubMed ID: 20880612
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats.
    Calama E; Morán A; Ortiz de Urbina AV; Martín ML; San Román L
    Pharmacology; 2004 Jun; 71(2):66-72. PubMed ID: 15118345
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.