BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

257 related articles for article (PubMed ID: 23086478)

  • 1. NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.
    Giambra V; Jenkins CR; Wang H; Lam SH; Shevchuk OO; Nemirovsky O; Wai C; Gusscott S; Chiang MY; Aster JC; Humphries RK; Eaves C; Weng AP
    Nat Med; 2012 Nov; 18(11):1693-8. PubMed ID: 23086478
    [TBL] [Abstract][Full Text] [Related]  

  • 2. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.
    Hales EC; Taub JW; Matherly LH
    Cell Signal; 2014 Jan; 26(1):149-61. PubMed ID: 24140475
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.
    Tatarek J; Cullion K; Ashworth T; Gerstein R; Aster JC; Kelliher MA
    Blood; 2011 Aug; 118(6):1579-90. PubMed ID: 21670468
    [TBL] [Abstract][Full Text] [Related]  

  • 4. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
    Ma W; Gutierrez A; Goff DJ; Geron I; Sadarangani A; Jamieson CA; Court AC; Shih AY; Jiang Q; Wu CC; Li K; Smith KM; Crews LA; Gibson NW; Deichaite I; Morris SR; Wei P; Carson DA; Look AT; Jamieson CH
    PLoS One; 2012; 7(6):e39725. PubMed ID: 22768113
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.
    Kong G; Du J; Liu Y; Meline B; Chang YI; Ranheim EA; Wang J; Zhang J
    J Biol Chem; 2013 Jun; 288(25):18219-27. PubMed ID: 23673656
    [TBL] [Abstract][Full Text] [Related]  

  • 6. RUNX1 is required for oncogenic
    Choi A; Illendula A; Pulikkan JA; Roderick JE; Tesell J; Yu J; Hermance N; Zhu LJ; Castilla LH; Bushweller JH; Kelliher MA
    Blood; 2017 Oct; 130(15):1722-1733. PubMed ID: 28790107
    [TBL] [Abstract][Full Text] [Related]  

  • 7. IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia.
    González-García S; Mosquera M; Fuentes P; Palumbo T; Escudero A; Pérez-Martínez A; Ramírez M; Corcoran AE; Toribio ML
    Blood; 2019 Dec; 134(24):2171-2182. PubMed ID: 31530562
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.
    García-Peydró M; Fuentes P; Mosquera M; García-León MJ; Alcain J; Rodríguez A; García de Miguel P; Menéndez P; Weijer K; Spits H; Scadden DT; Cuesta-Mateos C; Muñoz-Calleja C; Sánchez-Madrid F; Toribio ML
    J Clin Invest; 2018 Jul; 128(7):2802-2818. PubMed ID: 29781813
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.
    Pajcini KV; Xu L; Shao L; Petrovic J; Palasiewicz K; Ohtani Y; Bailis W; Lee C; Wertheim GB; Mani R; Muthusamy N; Li Y; Meijerink JPP; Blacklow SC; Faryabi RB; Cherry S; Pear WS
    Sci Signal; 2017 Nov; 10(505):. PubMed ID: 29138297
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia.
    Koyama D; Kikuchi J; Hiraoka N; Wada T; Kurosawa H; Chiba S; Furukawa Y
    Leukemia; 2014 Jun; 28(6):1216-26. PubMed ID: 24301524
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia.
    Jena N; Sheng J; Hu JK; Li W; Zhou W; Lee G; Tsichlis N; Pathak A; Brown N; Deshpande A; Luo C; Hu GF; Hinds PW; Van Etten RA; Hu MG
    Leukemia; 2016 May; 30(5):1033-43. PubMed ID: 26707936
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL.
    Piya S; Yang Y; Bhattacharya S; Sharma P; Ma H; Mu H; He H; Ruvolo V; Baran N; Davis RE; Jain AK; Konopleava M; Kantarjian H; Andreeff M; You MJ; Borthakur G
    Leukemia; 2022 May; 36(5):1261-1273. PubMed ID: 35173274
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL.
    Manicassamy S; Gupta S; Huang Z; Sun Z
    J Immunol; 2006 Jun; 176(11):6709-16. PubMed ID: 16709830
    [TBL] [Abstract][Full Text] [Related]  

  • 14. High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.
    Medyouf H; Gusscott S; Wang H; Tseng JC; Wai C; Nemirovsky O; Trumpp A; Pflumio F; Carboni J; Gottardis M; Pollak M; Kung AL; Aster JC; Holzenberger M; Weng AP
    J Exp Med; 2011 Aug; 208(9):1809-22. PubMed ID: 21807868
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome.
    Yokomizo-Nakano T; Kubota S; Bai J; Hamashima A; Morii M; Sun Y; Katagiri S; Iimori M; Kanai A; Tanaka D; Oshima M; Harada Y; Ohyashiki K; Iwama A; Harada H; Osato M; Sashida G
    Cancer Res; 2020 Jun; 80(12):2523-2536. PubMed ID: 32341038
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells.
    Zou J; Li P; Lu F; Liu N; Dai J; Ye J; Qu X; Sun X; Ma D; Park J; Ji C
    J Hematol Oncol; 2013 Jan; 6():3. PubMed ID: 23289374
    [TBL] [Abstract][Full Text] [Related]  

  • 17. CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia.
    Passaro D; Irigoyen M; Catherinet C; Gachet S; Da Costa De Jesus C; Lasgi C; Tran Quang C; Ghysdael J
    Cancer Cell; 2015 Jun; 27(6):769-79. PubMed ID: 26058076
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.
    Cullion K; Draheim KM; Hermance N; Tammam J; Sharma VM; Ware C; Nikov G; Krishnamoorthy V; Majumder PK; Kelliher MA
    Blood; 2009 Jun; 113(24):6172-81. PubMed ID: 19246562
    [TBL] [Abstract][Full Text] [Related]  

  • 19. NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity.
    Armstrong F; Brunet de la Grange P; Gerby B; Rouyez MC; Calvo J; Fontenay M; Boissel N; Dombret H; Baruchel A; Landman-Parker J; Roméo PH; Ballerini P; Pflumio F
    Blood; 2009 Feb; 113(8):1730-40. PubMed ID: 18984862
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia.
    Mendes RD; Canté-Barrett K; Pieters R; Meijerink JP
    Haematologica; 2016 Sep; 101(9):1010-7. PubMed ID: 27582570
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.