678 related articles for article (PubMed ID: 23087374)
1. The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.
Li Z; Guo J; Wu Y; Zhou Q
Nucleic Acids Res; 2013 Jan; 41(1):277-87. PubMed ID: 23087374
[TBL] [Abstract][Full Text] [Related]
2. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.
Boehm D; Calvanese V; Dar RD; Xing S; Schroeder S; Martins L; Aull K; Li PC; Planelles V; Bradner JE; Zhou MM; Siliciano RF; Weinberger L; Verdin E; Ott M
Cell Cycle; 2013 Feb; 12(3):452-62. PubMed ID: 23255218
[TBL] [Abstract][Full Text] [Related]
3. A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNP.
Wang C; Yang S; Lu H; You H; Ni M; Shan W; Lin T; Gao X; Chen H; Zhou Q; Xue Y
PLoS One; 2015; 10(11):e0142739. PubMed ID: 26569506
[TBL] [Abstract][Full Text] [Related]
4. Reactivation of latent HIV-1 by inhibition of BRD4.
Zhu J; Gaiha GD; John SP; Pertel T; Chin CR; Gao G; Qu H; Walker BD; Elledge SJ; Brass AL
Cell Rep; 2012 Oct; 2(4):807-16. PubMed ID: 23041316
[TBL] [Abstract][Full Text] [Related]
5. Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.
Bartholomeeusen K; Xiang Y; Fujinaga K; Peterlin BM
J Biol Chem; 2012 Oct; 287(43):36609-16. PubMed ID: 22952229
[TBL] [Abstract][Full Text] [Related]
6. A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs.
Abner E; Stoszko M; Zeng L; Chen HC; Izquierdo-Bouldstridge A; Konuma T; Zorita E; Fanunza E; Zhang Q; Mahmoudi T; Zhou MM; Filion GJ; Jordan A
J Virol; 2018 May; 92(10):. PubMed ID: 29343578
[TBL] [Abstract][Full Text] [Related]
7. HIV latency reversing agents act through Tat post translational modifications.
Khoury G; Mota TM; Li S; Tumpach C; Lee MY; Jacobson J; Harty L; Anderson JL; Lewin SR; Purcell DFJ
Retrovirology; 2018 May; 15(1):36. PubMed ID: 29751762
[TBL] [Abstract][Full Text] [Related]
8. The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency.
Li Z; Mbonye U; Feng Z; Wang X; Gao X; Karn J; Zhou Q
PLoS Pathog; 2018 Apr; 14(4):e1007012. PubMed ID: 29684085
[TBL] [Abstract][Full Text] [Related]
9. BET-Inhibitors Disrupt Rad21-Dependent Conformational Control of KSHV Latency.
Chen HS; De Leo A; Wang Z; Kerekovic A; Hills R; Lieberman PM
PLoS Pathog; 2017 Jan; 13(1):e1006100. PubMed ID: 28107481
[TBL] [Abstract][Full Text] [Related]
10. Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.
Mbonye U; Wang B; Gokulrangan G; Shi W; Yang S; Karn J
J Biol Chem; 2018 Jun; 293(26):10009-10025. PubMed ID: 29743242
[TBL] [Abstract][Full Text] [Related]
11. T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway.
Kim YK; Mbonye U; Hokello J; Karn J
J Mol Biol; 2011 Jul; 410(5):896-916. PubMed ID: 21763495
[TBL] [Abstract][Full Text] [Related]
12. Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors.
Donato E; Croci O; Sabò A; Muller H; Morelli MJ; Pelizzola M; Campaner S
Leukemia; 2017 Feb; 31(2):479-490. PubMed ID: 27443262
[TBL] [Abstract][Full Text] [Related]
13. Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.
Mbonye UR; Gokulrangan G; Datt M; Dobrowolski C; Cooper M; Chance MR; Karn J
PLoS Pathog; 2013; 9(5):e1003338. PubMed ID: 23658523
[TBL] [Abstract][Full Text] [Related]
14. Transcriptional Elongation Control of Hepatitis B Virus Covalently Closed Circular DNA Transcription by Super Elongation Complex and BRD4.
Francisco JC; Dai Q; Luo Z; Wang Y; Chong RH; Tan YJ; Xie W; Lee GH; Lin C
Mol Cell Biol; 2017 Oct; 37(19):. PubMed ID: 28694331
[TBL] [Abstract][Full Text] [Related]
15. Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II.
Lu X; Zhu X; Li Y; Liu M; Yu B; Wang Y; Rao M; Yang H; Zhou K; Wang Y; Chen Y; Chen M; Zhuang S; Chen LF; Liu R; Chen R
Nucleic Acids Res; 2016 Aug; 44(14):6853-67. PubMed ID: 27353326
[TBL] [Abstract][Full Text] [Related]
16. HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.
He N; Liu M; Hsu J; Xue Y; Chou S; Burlingame A; Krogan NJ; Alber T; Zhou Q
Mol Cell; 2010 May; 38(3):428-38. PubMed ID: 20471948
[TBL] [Abstract][Full Text] [Related]
17. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV.
Niu Q; Liu Z; Alamer E; Fan X; Chen H; Endsley J; Gelman BB; Tian B; Kim JH; Michael NL; Robb ML; Ananworanich J; Zhou J; Hu H
J Clin Invest; 2019 Jul; 129(8):3361-3373. PubMed ID: 31329163
[TBL] [Abstract][Full Text] [Related]
18. The HIV-1 Tat Protein: Mechanism of Action and Target for HIV-1 Cure Strategies.
Rice AP
Curr Pharm Des; 2017; 23(28):4098-4102. PubMed ID: 28677507
[TBL] [Abstract][Full Text] [Related]
19. HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.
Sobhian B; Laguette N; Yatim A; Nakamura M; Levy Y; Kiernan R; Benkirane M
Mol Cell; 2010 May; 38(3):439-51. PubMed ID: 20471949
[TBL] [Abstract][Full Text] [Related]
20. Super elongation complex promotes early HIV transcription and its function is modulated by P-TEFb.
Kuzmina A; Krasnopolsky S; Taube R
Transcription; 2017 May; 8(3):133-149. PubMed ID: 28340332
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]