184 related articles for article (PubMed ID: 23098137)
1. Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Zeng LF; Wang Y; Kazemi R; Xu S; Xu ZL; Sanchez TW; Yang LM; Debnath B; Odde S; Xie H; Zheng YT; Ding J; Neamati N; Long YQ
J Med Chem; 2012 Nov; 55(22):9492-509. PubMed ID: 23098137
[TBL] [Abstract][Full Text] [Related]
2. A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Hazuda DJ; Anthony NJ; Gomez RP; Jolly SM; Wai JS; Zhuang L; Fisher TE; Embrey M; Guare JP; Egbertson MS; Vacca JP; Huff JR; Felock PJ; Witmer MV; Stillmock KA; Danovich R; Grobler J; Miller MD; Espeseth AS; Jin L; Chen IW; Lin JH; Kassahun K; Ellis JD; Wong BK; Xu W; Pearson PG; Schleif WA; Cortese R; Emini E; Summa V; Holloway MK; Young SD
Proc Natl Acad Sci U S A; 2004 Aug; 101(31):11233-8. PubMed ID: 15277684
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Melamed JY; Egbertson MS; Varga S; Vacca JP; Moyer G; Gabryelski L; Felock PJ; Stillmock KA; Witmer MV; Schleif W; Hazuda DJ; Leonard Y; Jin L; Ellis JD; Young SD
Bioorg Med Chem Lett; 2008 Oct; 18(19):5307-10. PubMed ID: 18774711
[TBL] [Abstract][Full Text] [Related]
4. A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Guare JP; Wai JS; Gomez RP; Anthony NJ; Jolly SM; Cortes AR; Vacca JP; Felock PJ; Stillmock KA; Schleif WA; Moyer G; Gabryelski LJ; Jin L; Chen IW; Hazuda DJ; Young SD
Bioorg Med Chem Lett; 2006 Jun; 16(11):2900-4. PubMed ID: 16554152
[TBL] [Abstract][Full Text] [Related]
5. QSAR study of substituted 1,3,4-oxadiazole naphthyridines as HIV-1 integrase inhibitors.
Ravichandran V; Shalini S; Sundram K; Sokkalingam AD
Eur J Med Chem; 2010 Jul; 45(7):2791-7. PubMed ID: 20347187
[TBL] [Abstract][Full Text] [Related]
6. Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
Zhuang L; Wai JS; Embrey MW; Fisher TE; Egbertson MS; Payne LS; Guare JP; Vacca JP; Hazuda DJ; Felock PJ; Wolfe AL; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Leonard YM; Lynch JJ; Michelson SR; Young SD
J Med Chem; 2003 Feb; 46(4):453-6. PubMed ID: 12570367
[TBL] [Abstract][Full Text] [Related]
7. The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Johns BA; Weatherhead JG; Allen SH; Thompson JB; Garvey EP; Foster SA; Jeffrey JL; Miller WH
Bioorg Med Chem Lett; 2009 Mar; 19(6):1802-6. PubMed ID: 19217781
[TBL] [Abstract][Full Text] [Related]
8. A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Embrey MW; Wai JS; Funk TW; Homnick CF; Perlow DS; Young SD; Vacca JP; Hazuda DJ; Felock PJ; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Jin L; Chen IW; Ellis JD; Wong BK; Lin JH; Leonard YM; Tsou NN; Zhuang L
Bioorg Med Chem Lett; 2005 Oct; 15(20):4550-4. PubMed ID: 16102965
[TBL] [Abstract][Full Text] [Related]
9. 1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position.
Johns BA; Weatherhead JG; Allen SH; Thompson JB; Garvey EP; Foster SA; Jeffrey JL; Miller WH
Bioorg Med Chem Lett; 2009 Mar; 19(6):1807-10. PubMed ID: 19217284
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.
Boros EE; Edwards CE; Foster SA; Fuji M; Fujiwara T; Garvey EP; Golden PL; Hazen RJ; Jeffrey JL; Johns BA; Kawasuji T; Kiyama R; Koble CS; Kurose N; Miller WH; Mote AL; Murai H; Sato A; Thompson JB; Woodward MC; Yoshinaga T
J Med Chem; 2009 May; 52(9):2754-61. PubMed ID: 19374386
[TBL] [Abstract][Full Text] [Related]
11. Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.
Zhao XZ; Smith SJ; Maskell DP; Métifiot M; Pye VE; Fesen K; Marchand C; Pommier Y; Cherepanov P; Hughes SH; Burke TR
J Med Chem; 2017 Sep; 60(17):7315-7332. PubMed ID: 28737946
[TBL] [Abstract][Full Text] [Related]
12. Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Johnson TW; Tanis SP; Butler SL; Dalvie D; Delisle DM; Dress KR; Flahive EJ; Hu Q; Kuehler JE; Kuki A; Liu W; McClellan GA; Peng Q; Plewe MB; Richardson PF; Smith GL; Solowiej J; Tran KT; Wang H; Yu X; Zhang J; Zhu H
J Med Chem; 2011 May; 54(9):3393-417. PubMed ID: 21446745
[TBL] [Abstract][Full Text] [Related]
13. New hexahydrodiazocino-naphthyridine triones as HIV-1 integrase inhibitors: WO2008048538 A1.
Cotelle P
Expert Opin Ther Pat; 2009 Jan; 19(1):87-93. PubMed ID: 19441900
[TBL] [Abstract][Full Text] [Related]
14. Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase.
Ma K; Wang P; Fu W; Wan X; Zhou L; Chu Y; Ye D
Bioorg Med Chem Lett; 2011 Nov; 21(22):6724-7. PubMed ID: 21996518
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.
Jin H; Cai RZ; Schacherer L; Jabri S; Tsiang M; Fardis M; Chen X; Chen JM; Kim CU
Bioorg Med Chem Lett; 2006 Aug; 16(15):3989-92. PubMed ID: 16723225
[TBL] [Abstract][Full Text] [Related]
16. HIV type 1 integrase inhibitors: from basic research to clinical implications.
Jegede O; Babu J; Di Santo R; McColl DJ; Weber J; Quiñones-Mateu M
AIDS Rev; 2008; 10(3):172-89. PubMed ID: 18820719
[TBL] [Abstract][Full Text] [Related]
17. A platform for designing HIV integrase inhibitors. Part 1: 2-hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores.
Kawasuji T; Yoshinaga T; Sato A; Yodo M; Fujiwara T; Kiyama R
Bioorg Med Chem; 2006 Dec; 14(24):8430-45. PubMed ID: 17010623
[TBL] [Abstract][Full Text] [Related]
18. Naphthoxazepine inhibitors of HIV-1 integrase: synthesis and biological evaluation.
Garofalo A; Grande F; Brizzi A; Aiello F; Dayam R; Neamati N
ChemMedChem; 2008 Jun; 3(6):986-90. PubMed ID: 18383063
[TBL] [Abstract][Full Text] [Related]
19. 5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.
Peese KM; Allard CW; Connolly T; Johnson BL; Li C; Patel M; Sorensen ME; Walker MA; Meanwell NA; McAuliffe B; Minassian B; Krystal M; Parker DD; Lewis HA; Kish K; Zhang P; Nolte RT; Simmermacher J; Jenkins S; Cianci C; Naidu BN
J Med Chem; 2019 Feb; 62(3):1348-1361. PubMed ID: 30609350
[TBL] [Abstract][Full Text] [Related]
20. 4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors.
Pace P; Spieser SA; Summa V
Bioorg Med Chem Lett; 2008 Jul; 18(14):3865-9. PubMed ID: 18595690
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
