These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 23103389)

  • 1. Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel.
    Xu X; Marni F; Wu S; Su Z; Musayev F; Shrestha S; Xie C; Gao W; Liu Q; Zhou L
    Structure; 2012 Dec; 20(12):2116-23. PubMed ID: 23103389
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis for the cAMP-dependent gating in the human HCN4 channel.
    Xu X; Vysotskaya ZV; Liu Q; Zhou L
    J Biol Chem; 2010 Nov; 285(47):37082-91. PubMed ID: 20829353
    [TBL] [Abstract][Full Text] [Related]  

  • 3. State-dependent cAMP binding to functioning HCN channels studied by patch-clamp fluorometry.
    Wu S; Vysotskaya ZV; Xu X; Xie C; Liu Q; Zhou L
    Biophys J; 2011 Mar; 100(5):1226-32. PubMed ID: 21354395
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia.
    Boulton S; Akimoto M; Akbarizadeh S; Melacini G
    J Biol Chem; 2017 Apr; 292(15):6414-6428. PubMed ID: 28174302
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The structure of the apo cAMP-binding domain of HCN4 - a stepping stone toward understanding the cAMP-dependent modulation of the hyperpolarization-activated cyclic-nucleotide-gated ion channels.
    Akimoto M; VanSchouwen B; Melacini G
    FEBS J; 2018 Jun; 285(12):2182-2192. PubMed ID: 29444387
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4.
    Liao Z; Lockhead D; St Clair JR; Larson ED; Wilson CE; Proenza C
    J Gen Physiol; 2012 Nov; 140(5):557-66. PubMed ID: 23109717
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions.
    Wang J; Chen S; Siegelbaum SA
    J Gen Physiol; 2001 Sep; 118(3):237-50. PubMed ID: 11524455
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
    Saponaro A; Pauleta SR; Cantini F; Matzapetakis M; Hammann C; Donadoni C; Hu L; Thiel G; Banci L; Santoro B; Moroni A
    Proc Natl Acad Sci U S A; 2014 Oct; 111(40):14577-82. PubMed ID: 25197093
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531.
    Li CH; Zhang Q; Teng B; Mustafa SJ; Huang JY; Yu HG
    Am J Physiol Cell Physiol; 2008 Jan; 294(1):C355-62. PubMed ID: 17977941
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.
    Akimoto M; Zhang Z; Boulton S; Selvaratnam R; VanSchouwen B; Gloyd M; Accili EA; Lange OF; Melacini G
    J Biol Chem; 2014 Aug; 289(32):22205-20. PubMed ID: 24878962
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.
    Han Y; Noam Y; Lewis AS; Gallagher JJ; Wadman WJ; Baram TZ; Chetkovich DM
    J Biol Chem; 2011 Jun; 286(23):20823-34. PubMed ID: 21504900
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channels.
    Kesters D; Brams M; Nys M; Wijckmans E; Spurny R; Voets T; Tytgat J; Kusch J; Ulens C
    PLoS One; 2015; 10(1):e0116369. PubMed ID: 25625648
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node.
    Liao Z; Lockhead D; Larson ED; Proenza C
    J Gen Physiol; 2010 Sep; 136(3):247-58. PubMed ID: 20713547
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.
    Chen S; Wang J; Zhou L; George MS; Siegelbaum SA
    J Gen Physiol; 2007 Feb; 129(2):175-88. PubMed ID: 17261842
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.
    Wu S; Gao W; Xie C; Xu X; Vorvis C; Marni F; Hackett AR; Liu Q; Zhou L
    J Gen Physiol; 2012 Jul; 140(1):29-39. PubMed ID: 22689828
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural basis for modulation and agonist specificity of HCN pacemaker channels.
    Zagotta WN; Olivier NB; Black KD; Young EC; Olson R; Gouaux E
    Nature; 2003 Sep; 425(6954):200-5. PubMed ID: 12968185
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel.
    Schünke S; Stoldt M; Lecher J; Kaupp UB; Willbold D
    Proc Natl Acad Sci U S A; 2011 Apr; 108(15):6121-6. PubMed ID: 21430265
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
    Lolicato M; Nardini M; Gazzarrini S; Möller S; Bertinetti D; Herberg FW; Bolognesi M; Martin H; Fasolini M; Bertrand JA; Arrigoni C; Thiel G; Moroni A
    J Biol Chem; 2011 Dec; 286(52):44811-20. PubMed ID: 22006928
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry.
    Ulens C; Siegelbaum SA
    Neuron; 2003 Dec; 40(5):959-70. PubMed ID: 14659094
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Altered cyclic nucleotide binding and pore opening in a diseased human HCN4 channel.
    Ng LCT; Li YX; Van Petegem F; Accili EA
    Biophys J; 2022 Apr; 121(7):1166-1183. PubMed ID: 35219649
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.