BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 23106316)

  • 1. 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.
    Wilhelm A; Lopez-Garcia LA; Busschots K; Fröhner W; Maurer F; Boettcher S; Zhang H; Schulze JO; Biondi RM; Engel M
    J Med Chem; 2012 Nov; 55(22):9817-30. PubMed ID: 23106316
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1.
    Wei L; Gao X; Warne R; Hao X; Bussiere D; Gu XJ; Uno T; Liu Y
    Bioorg Med Chem Lett; 2010 Jul; 20(13):3897-902. PubMed ID: 20627557
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.
    Busschots K; Lopez-Garcia LA; Lammi C; Stroba A; Zeuzem S; Piiper A; Alzari PM; Neimanis S; Arencibia JM; Engel M; Schulze JO; Biondi RM
    Chem Biol; 2012 Sep; 19(9):1152-63. PubMed ID: 22999883
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.
    Stroba A; Schaeffer F; Hindie V; Lopez-Garcia L; Adrian I; Fröhner W; Hartmann RW; Biondi RM; Engel M
    J Med Chem; 2009 Aug; 52(15):4683-93. PubMed ID: 19606904
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H-15N TROSY experiments.
    Stockman BJ; Kothe M; Kohls D; Weibley L; Connolly BJ; Sheils AL; Cao Q; Cheng AC; Yang L; Kamath AV; Ding YH; Charlton ME
    Chem Biol Drug Des; 2009 Feb; 73(2):179-88. PubMed ID: 19207420
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
    Schulze JO; Saladino G; Busschots K; Neimanis S; Süß E; Odadzic D; Zeuzem S; Hindie V; Herbrand AK; Lisa MN; Alzari PM; Gervasio FL; Biondi RM
    Cell Chem Biol; 2016 Oct; 23(10):1193-1205. PubMed ID: 27693059
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Use of a fluorescent ATP analog to probe the allosteric conformational change in the active site of the protein kinase PDK1.
    Hindie V; Lopez-Garcia LA; Biondi RM
    Methods Mol Biol; 2012; 928():133-41. PubMed ID: 22956138
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKCζ.
    Fröhner W; Lopez-Garcia LA; Neimanis S; Weber N; Navratil J; Maurer F; Stroba A; Zhang H; Biondi RM; Engel M
    J Med Chem; 2011 Oct; 54(19):6714-23. PubMed ID: 21863889
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
    Rettenmaier TJ; Sadowsky JD; Thomsen ND; Chen SC; Doak AK; Arkin MR; Wells JA
    Proc Natl Acad Sci U S A; 2014 Dec; 111(52):18590-5. PubMed ID: 25518860
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1.
    Xu X; Chen Y; Fu Q; Ni D; Zhang J; Li X; Lu S
    J Enzyme Inhib Med Chem; 2019 Dec; 34(1):361-374. PubMed ID: 30734603
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
    Sadowsky JD; Burlingame MA; Wolan DW; McClendon CL; Jacobson MP; Wells JA
    Proc Natl Acad Sci U S A; 2011 Apr; 108(15):6056-61. PubMed ID: 21430264
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fused protein of deltaPKC activation loop and PDK1-interacting fragment (deltaAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells.
    Seki T; Irie N; Nakamura K; Sakaue H; Ogawa W; Kasuga M; Yamamoto H; Ohmori S; Saito N; Sakai N
    Genes Cells; 2006 Sep; 11(9):1051-70. PubMed ID: 16923125
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Allosteric activation of the protein kinase PDK1 with low molecular weight compounds.
    Engel M; Hindie V; Lopez-Garcia LA; Stroba A; Schaeffer F; Adrian I; Imig J; Idrissova L; Nastainczyk W; Zeuzem S; Alzari PM; Hartmann RW; Piiper A; Biondi RM
    EMBO J; 2006 Nov; 25(23):5469-80. PubMed ID: 17110931
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of SBF1 as an allosteric inhibitor targeting the PIF-pocket of 3-phosphoinositide-dependent protein kinase-1.
    Liu W; Li P; Mei Y
    J Mol Model; 2019 Jun; 25(7):187. PubMed ID: 31197600
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.
    Islam I; Bryant J; Chou YL; Kochanny MJ; Lee W; Phillips GB; Yu H; Adler M; Whitlow M; Ho E; Lentz D; Polokoff MA; Subramanyam B; Wu JM; Zhu D; Feldman RI; Arnaiz DO
    Bioorg Med Chem Lett; 2007 Jul; 17(14):3814-8. PubMed ID: 17531483
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening.
    Lee AC; Ramanujulu PM; Poulsen A; Williams M; Blanchard S; Ma DM; Bonday Z; Goh KL; Goh KC; Goh MK; Wood J; Dymock BW
    Bioorg Med Chem Lett; 2012 Jun; 22(12):4023-7. PubMed ID: 22591730
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking.
    Rettenmaier TJ; Fan H; Karpiak J; Doak A; Sali A; Shoichet BK; Wells JA
    J Med Chem; 2015 Oct; 58(20):8285-8291. PubMed ID: 26443011
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA.
    Biondi RM; Cheung PC; Casamayor A; Deak M; Currie RA; Alessi DR
    EMBO J; 2000 Mar; 19(5):979-88. PubMed ID: 10698939
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound.
    Zhang H; Neimanis S; Lopez-Garcia LA; Arencibia JM; Amon S; Stroba A; Zeuzem S; Proschak E; Stark H; Bauer AF; Busschots K; Jørgensen TJ; Engel M; Schulze JO; Biondi RM
    Chem Biol; 2014 Jun; 21(6):754-65. PubMed ID: 24836908
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The design and synthesis of novel alpha-ketoamide-based p38 MAP kinase inhibitors.
    Montalban AG; Boman E; Chang CD; Ceide SC; Dahl R; Dalesandro D; Delaet NG; Erb E; Ernst JT; Gibbs A; Kahl J; Kessler L; Lundström J; Miller S; Nakanishi H; Roberts E; Saiah E; Sullivan R; Wang Z; Larson CJ
    Bioorg Med Chem Lett; 2008 Mar; 18(6):1772-7. PubMed ID: 18325768
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.