BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 23117549)

  • 1. Virtual and experimental high-throughput screening (HTS) in search of novel inosine 5'-monophosphate dehydrogenase II (IMPDH II) inhibitors.
    Dunkern T; Prabhu A; Kharkar PS; Goebel H; Rolser E; Burckhard-Boer W; Arumugam P; Makhija MT
    J Comput Aided Mol Des; 2012 Nov; 26(11):1277-92. PubMed ID: 23117549
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.
    Sintchak MD; Nimmesgern E
    Immunopharmacology; 2000 May; 47(2-3):163-84. PubMed ID: 10878288
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regulation of inosine monophosphate dehydrogenase type I and type II isoforms in human lymphocytes.
    Jain J; Almquist SJ; Ford PJ; Shlyakhter D; Wang Y; Nimmesgern E; Germann UA
    Biochem Pharmacol; 2004 Feb; 67(4):767-76. PubMed ID: 14757177
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).
    Cuny GD; Suebsuwong C; Ray SS
    Expert Opin Ther Pat; 2017 Jun; 27(6):677-690. PubMed ID: 28074661
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents.
    Shah CP; Kharkar PS
    Eur J Med Chem; 2018 Oct; 158():286-301. PubMed ID: 30223117
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic Acid by GTP.
    Ji Y; Gu J; Makhov AM; Griffith JD; Mitchell BS
    J Biol Chem; 2006 Jan; 281(1):206-12. PubMed ID: 16243838
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives.
    Mitsuhashi S; Takenaka J; Iwamori K; Nakajima N; Ubukata M
    Bioorg Med Chem; 2010 Nov; 18(22):8106-11. PubMed ID: 20934342
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selective inhibition of human Molt-4 leukemia type II inosine 5'-monophosphate dehydrogenase by the 1,5-diazabicyclo[3.1.0]hexane-2,4-diones.
    Barnes BJ; Eakin AE; Izydore RA; Hall IH
    Biochemistry; 2000 Nov; 39(45):13641-50. PubMed ID: 11076502
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inosine 5'-monophosphate dehydrogenase inhibitors for the treatment of autoimmune diseases.
    Ratcliffe AJ
    Curr Opin Drug Discov Devel; 2006 Sep; 9(5):595-605. PubMed ID: 17002220
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid.
    Digits JA; Hedstrom L
    Biochemistry; 1999 Nov; 38(46):15388-97. PubMed ID: 10563825
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A novel series of non-nucleoside inhibitors of inosine 5'-monophosphate dehydrogenase with immunosuppressive activity.
    Franklin TJ; Morris WP; Jacobs VN; Culbert EJ; Heys CA; Ward WH; Cook PN; Jung F; Plé P
    Biochem Pharmacol; 1999 Sep; 58(5):867-76. PubMed ID: 10449198
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.
    Sarwono AEY; Mitsuhashi S; Kabir MHB; Shigetomi K; Okada T; Ohsaka F; Otsuguro S; Maenaka K; Igarashi M; Kato K; Ubukata M
    J Enzyme Inhib Med Chem; 2019 Dec; 34(1):171-178. PubMed ID: 30451014
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and biological evaluation of novel inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.
    Dunkern T; Chavan S; Bankar D; Patil A; Kulkarni P; Kharkar PS; Prabhu A; Goebel H; Rolser E; Burckhard-Boer W; Arumugam P; Makhija MT
    J Enzyme Inhib Med Chem; 2014 Jun; 29(3):408-19. PubMed ID: 23663081
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding site.
    Prosise GL; Wu JZ; Luecke H
    J Biol Chem; 2002 Dec; 277(52):50654-9. PubMed ID: 12235158
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inosine 5'-Monophosphate Dehydrogenase (IMPDH) as a Potential Target for the Development of a New Generation of Antiprotozoan Agents.
    Fotie J
    Mini Rev Med Chem; 2018; 18(8):656-671. PubMed ID: 27334467
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor.
    Jain J; Almquist SJ; Heiser AD; Shlyakhter D; Leon E; Memmott C; Moody CS; Nimmesgern E; Decker C
    J Pharmacol Exp Ther; 2002 Sep; 302(3):1272-7. PubMed ID: 12183689
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inosine-5'-monophosphate dehydrogenase: regulation of expression and role in cellular proliferation and T lymphocyte activation.
    Zimmermann AG; Gu JJ; Laliberté J; Mitchell BS
    Prog Nucleic Acid Res Mol Biol; 1998; 61():181-209. PubMed ID: 9752721
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.
    Nair V; Shu Q
    Antivir Chem Chemother; 2007; 18(5):245-58. PubMed ID: 18046958
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
    Makowska-Grzyska M; Kim Y; Maltseva N; Osipiuk J; Gu M; Zhang M; Mandapati K; Gollapalli DR; Gorla SK; Hedstrom L; Joachimiak A
    J Biol Chem; 2015 Feb; 290(9):5893-911. PubMed ID: 25572472
    [TBL] [Abstract][Full Text] [Related]  

  • 20. [The determination and clinical application of inosine 5’-monophosphate dehydrogenase activity].
    Liu FY; Qiu XY; Jiao Z
    Yao Xue Xue Bao; 2016 Nov; 51(11):1666-73. PubMed ID: 29908108
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.