BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

244 related articles for article (PubMed ID: 23121379)

  • 1. Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity.
    Zhang K; Shafer BM; Demars MD; Stern HA; Fasan R
    J Am Chem Soc; 2012 Nov; 134(45):18695-704. PubMed ID: 23121379
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution.
    Kille S; Zilly FE; Acevedo JP; Reetz MT
    Nat Chem; 2011 Aug; 3(9):738-43. PubMed ID: 21860465
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.
    Kolev JN; Zaengle JM; Ravikumar R; Fasan R
    Chembiochem; 2014 May; 15(7):1001-10. PubMed ID: 24692265
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.
    Kolev JN; O'Dwyer KM; Jordan CT; Fasan R
    ACS Chem Biol; 2014 Jan; 9(1):164-73. PubMed ID: 24206617
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation.
    Roiban GD; Reetz MT
    Chem Commun (Camb); 2015 Feb; 51(12):2208-24. PubMed ID: 25483552
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).
    Dietrich JA; Yoshikuni Y; Fisher KJ; Woolard FX; Ockey D; McPhee DJ; Renninger NS; Chang MC; Baker D; Keasling JD
    ACS Chem Biol; 2009 Apr; 4(4):261-7. PubMed ID: 19271725
    [TBL] [Abstract][Full Text] [Related]  

  • 7. P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity.
    Zhang K; El Damaty S; Fasan R
    J Am Chem Soc; 2011 Mar; 133(10):3242-5. PubMed ID: 21341707
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Biocatalytic Enantioselective β-Hydroxylation of Unactivated C-H Bonds in Aliphatic Carboxylic Acids.
    Zhang K; Yu A; Chu X; Li F; Liu J; Liu L; Bai WJ; He C; Wang X
    Angew Chem Int Ed Engl; 2022 Jul; 61(28):e202204290. PubMed ID: 35536725
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Tuning the regio- and stereoselectivity of C-H activation in n-octanes by cytochrome P450 BM-3 with fluorine substituents: evidence for interactions between a C-F bond and aromatic π systems.
    Wu LL; Yang CL; Lo FC; Chiang CH; Chang CW; Ng KY; Chou HH; Hung HY; Chan SI; Yu SS
    Chemistry; 2011 Apr; 17(17):4774-87. PubMed ID: 21400620
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Achieving regio- and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution.
    Agudo R; Roiban GD; Reetz MT
    Chembiochem; 2012 Jul; 13(10):1465-73. PubMed ID: 22711296
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regio- and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants.
    Li A; Acevedo-Rocha CG; D'Amore L; Chen J; Peng Y; Garcia-Borràs M; Gao C; Zhu J; Rickerby H; Osuna S; Zhou J; Reetz MT
    Angew Chem Int Ed Engl; 2020 Jul; 59(30):12499-12505. PubMed ID: 32243054
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.
    Polic V; Auclair K
    Bioorg Med Chem; 2014 Oct; 22(20):5547-54. PubMed ID: 25035263
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs.
    Mancy A; Antignac M; Minoletti C; Dijols S; Mouries V; Duong NT; Battioni P; Dansette PM; Mansuy D
    Biochemistry; 1999 Oct; 38(43):14264-70. PubMed ID: 10572000
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cytochrome P450 catalyzed oxidative hydroxylation of achiral organic compounds with simultaneous creation of two chirality centers in a single C-H activation step.
    Roiban GD; Agudo R; Reetz MT
    Angew Chem Int Ed Engl; 2014 Aug; 53(33):8659-63. PubMed ID: 24590553
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanistic Study of the Stereoselective Hydroxylation of [2-
    Yang CL; Lin CH; Luo WI; Lee TL; Ramu R; Ng KY; Tsai YF; Wei GT; Yu SS
    Chemistry; 2017 Feb; 23(11):2571-2582. PubMed ID: 27798822
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural Basis for Selective Oxidation of Phosphorylated Ethylphenols by Cytochrome P450 Monooxygenase CreJ.
    Dong S; Chen J; Zhang X; Guo F; Ma L; You C; Wang X; Zhang W; Wan X; Liu SJ; Yao LS; Li S; Du L; Feng Y
    Appl Environ Microbiol; 2021 May; 87(11):. PubMed ID: 33712426
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Expanding the applicability of cytochrome P450s and other haemoproteins.
    Ariyasu S; Stanfield JK; Aiba Y; Shoji O
    Curr Opin Chem Biol; 2020 Dec; 59():155-163. PubMed ID: 32781431
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Computational Study of Engineered Cytochrome P450-Catalyzed C-H Amination: The Origin of the Regio- and Stereoselectivity.
    Li Z; Burnell DJ; Boyd RJ
    J Phys Chem B; 2017 Dec; 121(48):10859-10868. PubMed ID: 29131622
    [TBL] [Abstract][Full Text] [Related]  

  • 19. An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1.
    Seifert A; Antonovici M; Hauer B; Pleiss J
    Chembiochem; 2011 Jun; 12(9):1346-51. PubMed ID: 21591046
    [TBL] [Abstract][Full Text] [Related]  

  • 20. P450(BM3) on steroids: the Swiss Army knife P450 enzyme just gets better.
    Wong LL
    Chembiochem; 2011 Nov; 12(17):2537-9. PubMed ID: 21998091
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.