160 related articles for article (PubMed ID: 23122525)
1. Fluorescent nitrile-based inhibitors of cysteine cathepsins.
Frizler M; Mertens MD; Gütschow M
Bioorg Med Chem Lett; 2012 Dec; 22(24):7715-8. PubMed ID: 23122525
[TBL] [Abstract][Full Text] [Related]
2. Dipeptide-derived nitriles containing additional electrophilic sites: potentially irreversible inhibitors of cysteine proteases.
Löser R; Gütschow M
J Enzyme Inhib Med Chem; 2009 Dec; 24(6):1245-52. PubMed ID: 19912058
[TBL] [Abstract][Full Text] [Related]
3. Highly selective azadipeptide nitrile inhibitors for cathepsin K: design, synthesis and activity assays.
Ren XF; Li HW; Fang X; Wu Y; Wang L; Zou S
Org Biomol Chem; 2013 Feb; 11(7):1143-8. PubMed ID: 23299878
[TBL] [Abstract][Full Text] [Related]
4. Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
Löser R; Schilling K; Dimmig E; Gütschow M
J Med Chem; 2005 Dec; 48(24):7688-707. PubMed ID: 16302809
[TBL] [Abstract][Full Text] [Related]
5. Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins.
Nizi E; Sferrazza A; Fabbrini D; Nardi V; Andreini M; Graziani R; Gennari N; Bresciani A; Paonessa G; Harper S
Bioorg Med Chem Lett; 2018 May; 28(9):1540-1544. PubMed ID: 29615344
[TBL] [Abstract][Full Text] [Related]
6. Dipeptide nitrile inhibitors of cathepsin K.
Altmann E; Aichholz R; Betschart C; Buhl T; Green J; Lattmann R; Missbach M
Bioorg Med Chem Lett; 2006 May; 16(9):2549-54. PubMed ID: 16480867
[TBL] [Abstract][Full Text] [Related]
7. Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei.
Schirmeister T; Schmitz J; Jung S; Schmenger T; Krauth-Siegel RL; Gütschow M
Bioorg Med Chem Lett; 2017 Jan; 27(1):45-50. PubMed ID: 27890381
[TBL] [Abstract][Full Text] [Related]
8. Azadipeptide nitriles: highly potent and proteolytically stable inhibitors of papain-like cysteine proteases.
Löser R; Frizler M; Schilling K; Gütschow M
Angew Chem Int Ed Engl; 2008; 47(23):4331-4. PubMed ID: 18404765
[No Abstract] [Full Text] [Related]
9. Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F.
Frizler M; Schmitz J; Schulz-Fincke AC; Gütschow M
J Med Chem; 2012 Jun; 55(12):5982-6. PubMed ID: 22686657
[TBL] [Abstract][Full Text] [Related]
10. 5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Morley AD; Kenny PW; Burton B; Heald RA; Macfaul PA; Mullett J; Page K; Porres SS; Ribeiro LR; Smith P; Ward S; Wilkinson TJ
Bioorg Med Chem Lett; 2009 Mar; 19(6):1658-61. PubMed ID: 19231183
[TBL] [Abstract][Full Text] [Related]
11. Design, characterization and cellular uptake studies of fluorescence-labeled prototypic cathepsin inhibitors.
Kohl F; Schmitz J; Furtmann N; Schulz-Fincke AC; Mertens MD; Küppers J; Benkhoff M; Tobiasch E; Bartz U; Bajorath J; Stirnberg M; Gütschow M
Org Biomol Chem; 2015 Nov; 13(41):10310-23. PubMed ID: 26307943
[TBL] [Abstract][Full Text] [Related]
12. Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.
Altmann E; Cowan-Jacob SW; Missbach M
J Med Chem; 2004 Nov; 47(24):5833-6. PubMed ID: 15537340
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
Yang PY; Wang M; Li L; Wu H; He CY; Yao SQ
Chemistry; 2012 May; 18(21):6528-41. PubMed ID: 22488888
[TBL] [Abstract][Full Text] [Related]
14. Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors.
Ehmke V; Quinsaat JE; Rivera-Fuentes P; Heindl C; Freymond C; Rottmann M; Brun R; Schirmeister T; Diederich F
Org Biomol Chem; 2012 Aug; 10(30):5764-8. PubMed ID: 22336919
[TBL] [Abstract][Full Text] [Related]
15. Active Site Mapping of Human Cathepsin F with Dipeptide Nitrile Inhibitors.
Schmitz J; Furtmann N; Ponert M; Frizler M; Löser R; Bartz U; Bajorath J; Gütschow M
ChemMedChem; 2015 Aug; 10(8):1365-77. PubMed ID: 26119278
[TBL] [Abstract][Full Text] [Related]
16. Antimalarial activity of azadipeptide nitriles.
Löser R; Gut J; Rosenthal PJ; Frizler M; Gütschow M; Andrews KT
Bioorg Med Chem Lett; 2010 Jan; 20(1):252-5. PubMed ID: 19913414
[TBL] [Abstract][Full Text] [Related]
17. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor.
Ribeiro JFR; Cianni L; Li C; Warwick TG; de Vita D; Rosini F; Dos Reis Rocho F; Martins FCP; Kenny PW; Lameira J; Leitão A; Emsley J; Montanari CA
Bioorg Med Chem; 2020 Nov; 28(22):115743. PubMed ID: 33038787
[TBL] [Abstract][Full Text] [Related]
18. Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl.
Alper PB; Liu H; Chatterjee AK; Nguyen KT; Tully DC; Tumanut C; Li J; Harris JL; Tuntland T; Chang J; Gordon P; Hollenbeck T; Karanewsky DS
Bioorg Med Chem Lett; 2006 Mar; 16(6):1486-90. PubMed ID: 16412634
[TBL] [Abstract][Full Text] [Related]
19. 4-Amino-2-cyanopyrimidines: novel scaffold for nonpeptidic cathepsin S inhibitors.
Irie O; Yokokawa F; Ehara T; Iwasaki A; Iwaki Y; Hitomi Y; Konishi K; Kishida M; Toyao A; Masuya K; Gunji H; Sakaki J; Iwasaki G; Hirao H; Kanazawa T; Tanabe K; Kosaka T; Hart TW; Hallett A
Bioorg Med Chem Lett; 2008 Aug; 18(16):4642-6. PubMed ID: 18662880
[TBL] [Abstract][Full Text] [Related]
20. Development of nitrile-based peptidic inhibitors of cysteine cathepsins.
Frizler M; Stirnberg M; Sisay MT; Gütschow M
Curr Top Med Chem; 2010; 10(3):294-322. PubMed ID: 20166952
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]