240 related articles for article (PubMed ID: 23139415)
1. Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.
Courilleau D; Bisserier M; Jullian JC; Lucas A; Bouyssou P; Fischmeister R; Blondeau JP; Lezoualc'h F
J Biol Chem; 2012 Dec; 287(53):44192-202. PubMed ID: 23139415
[TBL] [Abstract][Full Text] [Related]
2. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1).
Courilleau D; Bouyssou P; Fischmeister R; Lezoualc'h F; Blondeau JP
Biochem Biophys Res Commun; 2013 Oct; 440(3):443-8. PubMed ID: 24099776
[TBL] [Abstract][Full Text] [Related]
3. Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: structure-function implications for Epac activation and inhibition.
Brown LM; Rogers KE; McCammon JA; Insel PA
J Biol Chem; 2014 Mar; 289(12):8217-30. PubMed ID: 24497631
[TBL] [Abstract][Full Text] [Related]
4. Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA.
Yu X; Zhang Q; Zhao Y; Schwarz BJ; Stallone JN; Heaps CL; Han G
PLoS One; 2017; 12(3):e0173085. PubMed ID: 28278256
[TBL] [Abstract][Full Text] [Related]
5. EPAC activation inhibits acetaldehyde-induced activation and proliferation of hepatic stellate cell via Rap1.
Yang Y; Yang F; Wu X; Lv X; Li J
Can J Physiol Pharmacol; 2016 May; 94(5):498-507. PubMed ID: 26854595
[TBL] [Abstract][Full Text] [Related]
6. Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.
Chepurny OG; Leech CA; Kelley GG; Dzhura I; Dzhura E; Li X; Rindler MJ; Schwede F; Genieser HG; Holz GG
J Biol Chem; 2009 Apr; 284(16):10728-36. PubMed ID: 19244230
[TBL] [Abstract][Full Text] [Related]
7. Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.
Rangarajan S; Enserink JM; Kuiperij HB; de Rooij J; Price LS; Schwede F; Bos JL
J Cell Biol; 2003 Feb; 160(4):487-93. PubMed ID: 12578910
[TBL] [Abstract][Full Text] [Related]
8. The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.
Zieba BJ; Artamonov MV; Jin L; Momotani K; Ho R; Franke AS; Neppl RL; Stevenson AS; Khromov AS; Chrzanowska-Wodnicka M; Somlyo AV
J Biol Chem; 2011 May; 286(19):16681-92. PubMed ID: 21454546
[TBL] [Abstract][Full Text] [Related]
9. Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.
Pereira L; Rehmann H; Lao DH; Erickson JR; Bossuyt J; Chen J; Bers DM
Proc Natl Acad Sci U S A; 2015 Mar; 112(13):3991-6. PubMed ID: 25829540
[TBL] [Abstract][Full Text] [Related]
10. Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.
Laurent AC; Bisserier M; Lucas A; Tortosa F; Roumieux M; De Régibus A; Swiader A; Sainte-Marie Y; Heymes C; Vindis C; Lezoualc'h F
Cardiovasc Res; 2015 Jan; 105(1):55-64. PubMed ID: 25411381
[TBL] [Abstract][Full Text] [Related]
11. Isoform-specific antagonists of exchange proteins directly activated by cAMP.
Tsalkova T; Mei FC; Li S; Chepurny OG; Leech CA; Liu T; Holz GG; Woods VL; Cheng X
Proc Natl Acad Sci U S A; 2012 Nov; 109(45):18613-8. PubMed ID: 23091014
[TBL] [Abstract][Full Text] [Related]
12. Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice.
Prajapati R; Fujita T; Suita K; Nakamura T; Cai W; Hidaka Y; Umemura M; Yokoyama U; Knollmann BC; Okumura S; Ishikawa Y
Circ J; 2019 Jan; 83(2):295-303. PubMed ID: 30518738
[TBL] [Abstract][Full Text] [Related]
13. Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.
Tiwari S; Felekkis K; Moon EY; Flies A; Sherr DH; Lerner A
Blood; 2004 Apr; 103(7):2661-7. PubMed ID: 14615375
[TBL] [Abstract][Full Text] [Related]
14. Possible roles of the cAMP-mediators EPAC and RAP1 in decidualization of rat uterus.
Kusama K; Yoshie M; Tamura K; Daikoku T; Takarada T; Tachikawa E
Reproduction; 2014 Jun; 147(6):897-906. PubMed ID: 24586073
[TBL] [Abstract][Full Text] [Related]
15. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
de Rooij J; Rehmann H; van Triest M; Cool RH; Wittinghofer A; Bos JL
J Biol Chem; 2000 Jul; 275(27):20829-36. PubMed ID: 10777494
[TBL] [Abstract][Full Text] [Related]
16. PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways.
Kwak HJ; Park KM; Choi HE; Chung KS; Lim HJ; Park HY
Cell Signal; 2008 May; 20(5):803-14. PubMed ID: 18276108
[TBL] [Abstract][Full Text] [Related]
17. Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac.
Rehmann H; Schwede F; Døskeland SO; Wittinghofer A; Bos JL
J Biol Chem; 2003 Oct; 278(40):38548-56. PubMed ID: 12888551
[TBL] [Abstract][Full Text] [Related]
18. MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion.
Gupta M; Yarwood SJ
J Biol Chem; 2005 Mar; 280(9):8109-16. PubMed ID: 15591041
[TBL] [Abstract][Full Text] [Related]
19. Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.
Li J; O'Connor KL; Cheng X; Mei FC; Uchida T; Townsend CM; Evers BM
Mol Endocrinol; 2007 Jan; 21(1):159-71. PubMed ID: 17068197
[TBL] [Abstract][Full Text] [Related]
20. Evidence for existence of cAMP-Epac signaling in the heads of mouse epididymal spermatozoa.
Amano R; Lee J; Goto N; Harayama H
J Reprod Dev; 2007 Feb; 53(1):127-33. PubMed ID: 17077580
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
