BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

188 related articles for article (PubMed ID: 23143678)

  • 1. The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors.
    Bonomo S; Tosco P; Giorgis M; Lolli M; Fruttero R
    J Mol Model; 2013 Mar; 19(3):1099-107. PubMed ID: 23143678
    [TBL] [Abstract][Full Text] [Related]  

  • 2. New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.
    Lolli ML; Giorgis M; Tosco P; Foti A; Fruttero R; Gasco A
    Eur J Med Chem; 2012 Mar; 49():102-9. PubMed ID: 22245049
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 1,2,5-Oxadiazole analogues of leflunomide and related compounds.
    Giorgis M; Lolli ML; Rolando B; Rao A; Tosco P; Chaurasia S; Marabello D; Fruttero R; Gasco A
    Eur J Med Chem; 2011 Jan; 46(1):383-92. PubMed ID: 21109332
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
    Zeng T; Zuo Z; Luo Y; Zhao Y; Yu Y; Chen Q
    FEBS Open Bio; 2019 Aug; 9(8):1348-1354. PubMed ID: 31087527
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors.
    Vyas VK; Ghate M
    Mini Rev Med Chem; 2011 Oct; 11(12):1039-55. PubMed ID: 21861807
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors.
    Azeredo LFSP; Coutinho JP; Jabor VAP; Feliciano PR; Nonato MC; Kaiser CR; Menezes CMS; Hammes ASO; Caffarena ER; Hoelz LVB; de Souza NB; Pereira GAN; Cerávolo IP; Krettli AU; Boechat N
    Eur J Med Chem; 2017 Jan; 126():72-83. PubMed ID: 27744189
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
    Hurt DE; Sutton AE; Clardy J
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1610-5. PubMed ID: 16406782
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
    Madak JT; Cuthbertson CR; Miyata Y; Tamura S; Petrunak EM; Stuckey JA; Han Y; He M; Sun D; Showalter HD; Neamati N
    J Med Chem; 2018 Jun; 61(12):5162-5186. PubMed ID: 29727569
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer.
    Madak JT; Bankhead A; Cuthbertson CR; Showalter HD; Neamati N
    Pharmacol Ther; 2019 Mar; 195():111-131. PubMed ID: 30347213
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
    Boschi D; Pippione AC; Sainas S; Lolli ML
    Eur J Med Chem; 2019 Dec; 183():111681. PubMed ID: 31557612
    [TBL] [Abstract][Full Text] [Related]  

  • 11. An in silico Workflow that Yields Experimentally Comparable Inhibitors for Human Dihydroorotate Dehydrogenase.
    M S; B P; Swaminathan P
    Curr Comput Aided Drug Des; 2020; 16(3):340-350. PubMed ID: 31132976
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide.
    Li SL; He MY; Du HG
    Int J Mol Sci; 2011; 12(5):2982-93. PubMed ID: 21686163
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.
    Sainas S; Pippione AC; Giorgis M; Lupino E; Goyal P; Ramondetti C; Buccinnà B; Piccinini M; Braga RC; Andrade CH; Andersson M; Moritzer AC; Friemann R; Mensa S; Al-Kadaraghi S; Boschi D; Lolli ML
    Eur J Med Chem; 2017 Mar; 129():287-302. PubMed ID: 28235702
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis of beta-hydroxy-propenamide derivatives and the inhibition of human dihydroorotate dehydrogenase.
    Kim TH; Na HS; Löffler M
    Arch Pharm Res; 2003 Mar; 26(3):197-201. PubMed ID: 12723931
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.
    Walse B; Dufe VT; Svensson B; Fritzson I; Dahlberg L; Khairoullina A; Wellmar U; Al-Karadaghi S
    Biochemistry; 2008 Aug; 47(34):8929-36. PubMed ID: 18672895
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials.
    Ojha PK; Roy K
    Eur J Med Chem; 2010 Oct; 45(10):4645-56. PubMed ID: 20708304
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
    DeRatt LG; Christine Pietsch E; Tanner A; Shaffer P; Jacoby E; Wang W; Kazmi F; Zhang X; Attar RM; Edwards JP; Kuduk SD
    Bioorg Med Chem Lett; 2020 Nov; 30(22):127589. PubMed ID: 33007394
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.
    Davies M; Heikkilä T; McConkey GA; Fishwick CW; Parsons MR; Johnson AP
    J Med Chem; 2009 May; 52(9):2683-93. PubMed ID: 19351152
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase.
    Boa AN; Canavan SP; Hirst PR; Ramsey C; Stead AM; McConkey GA
    Bioorg Med Chem; 2005 Mar; 13(6):1945-67. PubMed ID: 15727850
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
    Hurt DE; Widom J; Clardy J
    Acta Crystallogr D Biol Crystallogr; 2006 Mar; 62(Pt 3):312-23. PubMed ID: 16510978
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.