BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

214 related articles for article (PubMed ID: 23144769)

  • 1. Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts.
    Wehrmann ZT; Hulett TW; Huegel KL; Vaughan KT; Wiest O; Helquist P; Goodson H
    PLoS One; 2012; 7(10):e48561. PubMed ID: 23144769
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.
    Pipalia NH; Subramanian K; Mao S; Ralph H; Hutt DM; Scott SM; Balch WE; Maxfield FR
    J Lipid Res; 2017 Apr; 58(4):695-708. PubMed ID: 28193631
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.
    Pipalia NH; Cosner CC; Huang A; Chatterjee A; Bourbon P; Farley N; Helquist P; Wiest O; Maxfield FR
    Proc Natl Acad Sci U S A; 2011 Apr; 108(14):5620-5. PubMed ID: 21436030
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.
    Rosenbaum AI; Zhang G; Warren JD; Maxfield FR
    Proc Natl Acad Sci U S A; 2010 Mar; 107(12):5477-82. PubMed ID: 20212119
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice.
    Ashikawa H; Mogi H; Honda T; Nakamura H; Murayama T
    Eur J Pharmacol; 2021 Apr; 896():173907. PubMed ID: 33503462
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease.
    Subramanian K; Rauniyar N; Lavalleé-Adam M; Yates JR; Balch WE
    Mol Cell Proteomics; 2017 Nov; 16(11):1938-1957. PubMed ID: 28860124
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy.
    Yu D; Swaroop M; Wang M; Baxa U; Yang R; Yan Y; Coksaygan T; DeTolla L; Marugan JJ; Austin CP; McKew JC; Gong DW; Zheng W
    J Biomol Screen; 2014 Sep; 19(8):1164-73. PubMed ID: 24907126
    [TBL] [Abstract][Full Text] [Related]  

  • 8. β-Cyclodextrin-threaded biocleavable polyrotaxanes ameliorate impaired autophagic flux in Niemann-Pick type C disease.
    Tamura A; Yui N
    J Biol Chem; 2015 Apr; 290(15):9442-54. PubMed ID: 25713067
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1.
    Singhal A; Szente L; Hildreth JEK; Song B
    Cell Death Dis; 2018 Oct; 9(10):1019. PubMed ID: 30282967
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression.
    Davidson CD; Ali NF; Micsenyi MC; Stephney G; Renault S; Dobrenis K; Ory DS; Vanier MT; Walkley SU
    PLoS One; 2009 Sep; 4(9):e6951. PubMed ID: 19750228
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evidence of redox imbalance and mitochondrial dysfunction in Niemann-Pick type C 1 patients: the in vitro effect of combined therapy with antioxidants and β-cyclodextrin nanoparticles.
    Hammerschmidt TG; Donida B; Raabe M; Faverzani JL; de Fátima Lopes F; Machado AZ; Kessler RG; Reinhardt LS; Poletto F; Moura DJ; Vargas CR
    Metab Brain Dis; 2023 Feb; 38(2):507-518. PubMed ID: 36447062
    [TBL] [Abstract][Full Text] [Related]  

  • 12. FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.
    Newton J; Hait NC; Maceyka M; Colaco A; Maczis M; Wassif CA; Cougnoux A; Porter FD; Milstien S; Platt N; Platt FM; Spiegel S
    FASEB J; 2017 Apr; 31(4):1719-1730. PubMed ID: 28082351
    [TBL] [Abstract][Full Text] [Related]  

  • 13. In vitro evaluation of 2-hydroxyalkylated β-cyclodextrins as potential therapeutic agents for Niemann-Pick Type C disease.
    Kondo Y; Tokumaru H; Ishitsuka Y; Matsumoto T; Taguchi M; Motoyama K; Higashi T; Arima H; Matsuo M; Higaki K; Ohno K; Irie T
    Mol Genet Metab; 2016 Jul; 118(3):214-219. PubMed ID: 27184436
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Normalization of cholesterol homeostasis by 2-hydroxypropyl-β-cyclodextrin in neurons and glia from Niemann-Pick C1 (NPC1)-deficient mice.
    Peake KB; Vance JE
    J Biol Chem; 2012 Mar; 287(12):9290-8. PubMed ID: 22277650
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Primary cilium alterations and expression changes of Patched1 proteins in niemann-pick type C disease.
    Formichi P; Battisti C; De Santi MM; Guazzo R; Tripodi SA; Radi E; Rossi B; Tarquini E; Federico A
    J Cell Physiol; 2018 Jan; 233(1):663-672. PubMed ID: 28332184
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Systemic administration of 2-hydroxypropyl-β-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function.
    Lopez AM; Terpack SJ; Posey KS; Liu B; Ramirez CM; Turley SD
    Clin Exp Pharmacol Physiol; 2014 Oct; 41(10):780-7. PubMed ID: 25115571
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Different Trafficking Phenotypes of Niemann-Pick C1 Gene Mutations Correlate with Various Alterations in Lipid Storage, Membrane Composition and Miglustat Amenability.
    Brogden G; Shammas H; Walters F; Maalouf K; Das AM; Naim HY; Rizk S
    Int J Mol Sci; 2020 Mar; 21(6):. PubMed ID: 32204338
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C.
    Yasmin N; Ishitsuka Y; Fukaura M; Yamada Y; Nakahara S; Ishii A; Kondo Y; Takeo T; Nakagata N; Motoyama K; Higashi T; Okada Y; Nishikawa J; Ichikawa A; Iohara D; Hirayama F; Higaki K; Ohno K; Matsuo M; Irie T
    Int J Mol Sci; 2019 Mar; 20(5):. PubMed ID: 30845767
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1.
    Prabhu AV; Kang I; De Pace R; Wassif CA; Fujiwara H; Kell P; Jiang X; Ory DS; Bonifacino JS; Ward ME; Porter FD
    BMC Biol; 2021 Oct; 19(1):218. PubMed ID: 34592985
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Normalization of Hepatic Homeostasis in the
    Munkacsi AB; Hammond N; Schneider RT; Senanayake DS; Higaki K; Lagutin K; Bloor SJ; Ory DS; Maue RA; Chen FW; Hernandez-Ono A; Dahlson N; Repa JJ; Ginsberg HN; Ioannou YA; Sturley SL
    J Biol Chem; 2017 Mar; 292(11):4395-4410. PubMed ID: 28031458
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.