89 related articles for article (PubMed ID: 23148825)
1. Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing.
Rouleau M; Collin P; Bellemare J; Harvey M; Guillemette C
Biochem J; 2013 Feb; 450(1):107-14. PubMed ID: 23148825
[TBL] [Abstract][Full Text] [Related]
2. Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus.
Lévesque E; Girard H; Journault K; Lépine J; Guillemette C
Hepatology; 2007 Jan; 45(1):128-38. PubMed ID: 17187418
[TBL] [Abstract][Full Text] [Related]
3. Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.
Bellemare J; Rouleau M; Girard H; Harvey M; Guillemette C
Drug Metab Dispos; 2010 Oct; 38(10):1785-9. PubMed ID: 20610558
[TBL] [Abstract][Full Text] [Related]
4. Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions.
Bellemare J; Rouleau M; Harvey M; Guillemette C
J Biol Chem; 2010 Feb; 285(6):3600-3607. PubMed ID: 19996319
[TBL] [Abstract][Full Text] [Related]
5. The relative protein abundance of UGT1A alternative splice variants as a key determinant of glucuronidation activity in vitro.
Rouleau M; Roberge J; Falardeau SA; Villeneuve L; Guillemette C
Drug Metab Dispos; 2013 Apr; 41(4):694-7. PubMed ID: 23360619
[TBL] [Abstract][Full Text] [Related]
6. Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans.
Bellemare J; Rouleau M; Harvey M; Popa I; Pelletier G; Têtu B; Guillemette C
J Pathol; 2011 Feb; 223(3):425-35. PubMed ID: 21171088
[TBL] [Abstract][Full Text] [Related]
7. Modulation of the UGT2B7 enzyme activity by C-terminally truncated proteins derived from alternative splicing.
Ménard V; Collin P; Margaillan G; Guillemette C
Drug Metab Dispos; 2013 Dec; 41(12):2197-205. PubMed ID: 24088326
[TBL] [Abstract][Full Text] [Related]
8. Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.
Girard H; Lévesque E; Bellemare J; Journault K; Caillier B; Guillemette C
Pharmacogenet Genomics; 2007 Dec; 17(12):1077-89. PubMed ID: 18004212
[TBL] [Abstract][Full Text] [Related]
9. Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines.
Bellemare J; Rouleau M; Harvey M; Têtu B; Guillemette C
Pharmacogenomics J; 2010 Oct; 10(5):431-41. PubMed ID: 19997083
[TBL] [Abstract][Full Text] [Related]
10. Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1).
Ghosh SS; Lu Y; Lee SW; Wang X; Guha C; Roy-Chowdhury J; Roy-Chowdhury N
Biochem J; 2005 Dec; 392(Pt 3):685-92. PubMed ID: 16171463
[TBL] [Abstract][Full Text] [Related]
11. Identification and functional characterization of a novel UDP-glucuronosyltransferase 2A1 splice variant: potential importance in tobacco-related cancer susceptibility.
Bushey RT; Lazarus P
J Pharmacol Exp Ther; 2012 Dec; 343(3):712-24. PubMed ID: 22984225
[TBL] [Abstract][Full Text] [Related]
12. A molecular model of the human UDP-glucuronosyltransferase 1A1, its membrane orientation, and the interactions between different parts of the enzyme.
Laakkonen L; Finel M
Mol Pharmacol; 2010 Jun; 77(6):931-9. PubMed ID: 20215562
[TBL] [Abstract][Full Text] [Related]
13. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.
Operaña TN; Tukey RH
J Biol Chem; 2007 Feb; 282(7):4821-4829. PubMed ID: 17179145
[TBL] [Abstract][Full Text] [Related]
14. Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates.
Udomuksorn W; Elliot DJ; Lewis BC; Mackenzie PI; Yoovathaworn K; Miners JO
Pharmacogenet Genomics; 2007 Dec; 17(12):1017-29. PubMed ID: 18004206
[TBL] [Abstract][Full Text] [Related]
15. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2.
Walle T; Otake Y; Galijatovic A; Ritter JK; Walle UK
Drug Metab Dispos; 2000 Sep; 28(9):1077-82. PubMed ID: 10950852
[TBL] [Abstract][Full Text] [Related]
16. Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.
van Es HH; Bout A; Liu J; Anderson L; Duncan AM; Bosma P; Oude Elferink R; Jansen PL; Chowdhury JR; Schurr E
Cytogenet Cell Genet; 1993; 63(2):114-6. PubMed ID: 8467709
[TBL] [Abstract][Full Text] [Related]
17. Glucuronidation of antiallergic drug, Tranilast: identification of human UDP-glucuronosyltransferase isoforms and effect of its phase I metabolite.
Katoh M; Matsui T; Yokoi T
Drug Metab Dispos; 2007 Apr; 35(4):583-9. PubMed ID: 17220234
[TBL] [Abstract][Full Text] [Related]
18. Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype.
Kadakol A; Ghosh SS; Sappal BS; Sharma G; Chowdhury JR; Chowdhury NR
Hum Mutat; 2000 Oct; 16(4):297-306. PubMed ID: 11013440
[TBL] [Abstract][Full Text] [Related]
19. Intergenic Splicing between Four Adjacent
Hu DG; Hulin JA; Wijayakumara DD; McKinnon RA; Mackenzie PI; Meech R
Mol Pharmacol; 2018 Sep; 94(3):938-952. PubMed ID: 29959221
[TBL] [Abstract][Full Text] [Related]
20. Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation.
Lévesque E; Ménard V; Laverdière I; Bellemare J; Barbier O; Girard H; Guillemette C
Pharmacogenet Genomics; 2010 Mar; 20(3):195-210. PubMed ID: 20139797
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]