BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 23152503)

  • 1. Interplay between α-, β-, and γ-secretases determines biphasic amyloid-β protein level in the presence of a γ-secretase inhibitor.
    Ortega F; Stott J; Visser SA; Bendtsen C
    J Biol Chem; 2013 Jan; 288(2):785-92. PubMed ID: 23152503
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.
    Burton CR; Meredith JE; Barten DM; Goldstein ME; Krause CM; Kieras CJ; Sisk L; Iben LG; Polson C; Thompson MW; Lin XA; Corsa J; Fiedler T; Pierdomenico M; Cao Y; Roach AH; Cantone JL; Ford MJ; Drexler DM; Olson RE; Yang MG; Bergstrom CP; McElhone KE; Bronson JJ; Macor JE; Blat Y; Grafstrom RH; Stern AM; Seiffert DA; Zaczek R; Albright CF; Toyn JH
    J Biol Chem; 2008 Aug; 283(34):22992-3003. PubMed ID: 18574238
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase.
    Li Y; Li H; Liang W; Li Y; Wang Z
    Front Biosci (Landmark Ed); 2024 Feb; 29(2):78. PubMed ID: 38420818
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
    Kokawa A; Ishihara S; Fujiwara H; Nobuhara M; Iwata M; Ihara Y; Funamoto S
    Acta Neuropathol Commun; 2015 Nov; 3():66. PubMed ID: 26531305
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides.
    Siegel G; Gerber H; Koch P; Bruestle O; Fraering PC; Rajendran L
    Cell Rep; 2017 Jun; 19(10):1967-1976. PubMed ID: 28591569
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.
    Gerber H; Wu F; Dimitrov M; Garcia Osuna GM; Fraering PC
    J Biol Chem; 2017 Mar; 292(9):3751-3767. PubMed ID: 28096459
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.
    Cook JJ; Wildsmith KR; Gilberto DB; Holahan MA; Kinney GG; Mathers PD; Michener MS; Price EA; Shearman MS; Simon AJ; Wang JX; Wu G; Yarasheski KE; Bateman RJ
    J Neurosci; 2010 May; 30(19):6743-50. PubMed ID: 20463236
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A; Hata S; Suzuki T
    J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.
    D'Onofrio G; Panza F; Frisardi V; Solfrizzi V; Imbimbo BP; Paroni G; Cascavilla L; Seripa D; Pilotto A
    Expert Opin Drug Discov; 2012 Jan; 7(1):19-37. PubMed ID: 22468891
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
    Checler F; Afram E; Pardossi-Piquard R; Lauritzen I
    J Biol Chem; 2021; 296():100489. PubMed ID: 33662398
    [TBL] [Abstract][Full Text] [Related]  

  • 12. γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.
    Ran Y; Cruz PE; Ladd TB; Fauq AH; Jung JI; Matthews J; Felsenstein KM; Golde TE
    J Biol Chem; 2014 Feb; 289(6):3276-87. PubMed ID: 24352661
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.
    Higashide H; Ishihara S; Nobuhara M; Ihara Y; Funamoto S
    J Neurochem; 2017 Mar; 140(6):955-962. PubMed ID: 28032911
    [TBL] [Abstract][Full Text] [Related]  

  • 14. BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis.
    Zhang S; Wang Z; Cai F; Zhang M; Wu Y; Zhang J; Song W
    J Neurosci; 2017 Jul; 37(29):6915-6925. PubMed ID: 28626014
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
    Liu L; Lauro BM; Wolfe MS; Selkoe DJ
    J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
    [TBL] [Abstract][Full Text] [Related]  

  • 16. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
    Scannevin RH; Chollate S; Brennan MS; Snodgrass-Belt PA; Peng H; Xu L; Jung MY; Bussiere T; Arastu MF; Talreja T; Xin Z; Dunstan RW; Fahrer D; Rohde E; Dunah AW; Wang J; Kumaravel G; Taveras AG; Moore Arnold H; Rhodes KJ
    Neuropharmacology; 2016 Apr; 103():57-68. PubMed ID: 26690893
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein.
    Barnwell E; Padmaraju V; Baranello R; Pacheco-Quinto J; Crosson C; Ablonczy Z; Eckman E; Eckman CB; Ramakrishnan V; Greig NH; Pappolla MA; Sambamurti K
    PLoS One; 2014; 9(3):e91531. PubMed ID: 24658363
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The C99 domain of the amyloid precursor protein resides in the disordered membrane phase.
    Capone R; Tiwari A; Hadziselimovic A; Peskova Y; Hutchison JM; Sanders CR; Kenworthy AK
    J Biol Chem; 2021; 296():100652. PubMed ID: 33839158
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.
    Kienlen-Campard P; Feyt C; Huysseune S; de Diesbach P; N'Kuli F; Courtoy PJ; Octave JN
    J Neurosci Res; 2006 Nov; 84(6):1311-22. PubMed ID: 16941495
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease.
    Portelius E; Zhang B; Gustavsson MK; Brinkmalm G; Westman-Brinkmalm A; Zetterberg H; Lee VM; Trojanowski JQ; Blennow K
    Neurodegener Dis; 2009; 6(5-6):258-62. PubMed ID: 19955704
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.