BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

277 related articles for article (PubMed ID: 23166698)

  • 1. Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.
    Cossu F; Milani M; Vachette P; Malvezzi F; Grassi S; Lecis D; Delia D; Drago C; Seneci P; Bolognesi M; Mastrangelo E
    PLoS One; 2012; 7(11):e49527. PubMed ID: 23166698
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis for bivalent Smac-mimetics recognition in the IAP protein family.
    Cossu F; Milani M; Mastrangelo E; Vachette P; Servida F; Lecis D; Canevari G; Delia D; Drago C; Rizzo V; Manzoni L; Seneci P; Scolastico C; Bolognesi M
    J Mol Biol; 2009 Sep; 392(3):630-44. PubMed ID: 19393243
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.
    Corti A; Milani M; Lecis D; Seneci P; de Rosa M; Mastrangelo E; Cossu F
    FEBS J; 2018 Sep; 285(17):3286-3298. PubMed ID: 30055105
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.
    Welsh K; Milutinovic S; Ardecky RJ; Gonzalez-Lopez M; Ganji SR; Teriete P; Finlay D; Riedl S; Matsuzawa S; Pinilla C; Houghten R; Vuori K; Reed JC; Cosford ND
    PLoS One; 2016; 11(9):e0161952. PubMed ID: 27617834
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac.
    Huang Y; Rich RL; Myszka DG; Wu H
    J Biol Chem; 2003 Dec; 278(49):49517-22. PubMed ID: 14512414
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The activator of apoptosis Smac-DIABLO acts as a tetramer in solution.
    Mastrangelo E; Vachette P; Cossu F; Malvezzi F; Bolognesi M; Milani M
    Biophys J; 2015 Feb; 108(3):714-23. PubMed ID: 25650938
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
    Zobel K; Wang L; Varfolomeev E; Franklin MC; Elliott LO; Wallweber HJ; Okawa DC; Flygare JA; Vucic D; Fairbrother WJ; Deshayes K
    ACS Chem Biol; 2006 Sep; 1(8):525-33. PubMed ID: 17168540
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
    Mastrangelo E; Cossu F; Milani M; Sorrentino G; Lecis D; Delia D; Manzoni L; Drago C; Seneci P; Scolastico C; Rizzo V; Bolognesi M
    J Mol Biol; 2008 Dec; 384(3):673-89. PubMed ID: 18851976
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.
    Samuel T; Welsh K; Lober T; Togo SH; Zapata JM; Reed JC
    J Biol Chem; 2006 Jan; 281(2):1080-90. PubMed ID: 16282325
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
    Vucic D; Franklin MC; Wallweber HJ; Das K; Eckelman BP; Shin H; Elliott LO; Kadkhodayan S; Deshayes K; Salvesen GS; Fairbrother WJ
    Biochem J; 2005 Jan; 385(Pt 1):11-20. PubMed ID: 15485396
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.
    Sun H; Nikolovska-Coleska Z; Lu J; Meagher JL; Yang CY; Qiu S; Tomita Y; Ueda Y; Jiang S; Krajewski K; Roller PP; Stuckey JA; Wang S
    J Am Chem Soc; 2007 Dec; 129(49):15279-94. PubMed ID: 17999504
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo.
    Gao Z; Tian Y; Wang J; Yin Q; Wu H; Li YM; Jiang X
    J Biol Chem; 2007 Oct; 282(42):30718-27. PubMed ID: 17724022
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.
    Cossu F; Mastrangelo E; Milani M; Sorrentino G; Lecis D; Delia D; Manzoni L; Seneci P; Scolastico C; Bolognesi M
    Biochem Biophys Res Commun; 2009 Jan; 378(2):162-7. PubMed ID: 18992220
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Theoretical studies on the interactions of XIAP-BIR3 domain with bicyclic and tricyclic core monovalent Smac mimetics.
    Ling B; Dong L; Zhang R; Wang Z; Liu Y; Liu C
    J Mol Graph Model; 2010 Nov; 29(3):354-62. PubMed ID: 20980180
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.
    Sun H; Lu J; Liu L; Yang CY; Wang S
    ACS Chem Biol; 2014 Apr; 9(4):994-1002. PubMed ID: 24521431
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of a heterodimeric Smac-based peptide that features sequences specific to both the BIR2 and BIR3 domains of the X-linked inhibitor of apoptosis protein.
    Speer KF; Cosimini CL; Splan KE
    Biopolymers; 2012; 98(2):122-30. PubMed ID: 22020922
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.
    Kester RF; Donnell AF; Lou Y; Remiszewski SW; Lombardo LJ; Chen S; Le NT; Lo J; Moliterni JA; Han X; Hogg JH; Liang W; Michoud C; Rupert KC; Mischke S; Le K; Weisel M; Janson CA; Lukacs CM; Fretland AJ; Hong K; Polonskaia A; Gao L; Li S; Solis DS; Aguilar D; Tardell C; Dvorozniak M; Tannu S; Lee EC; Schutt AD; Goggin B
    J Med Chem; 2013 Oct; 56(20):7788-803. PubMed ID: 24093940
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Recognition of Smac-mimetic compounds by the BIR domain of cIAP1.
    Cossu F; Malvezzi F; Canevari G; Mastrangelo E; Lecis D; Delia D; Seneci P; Scolastico C; Bolognesi M; Milani M
    Protein Sci; 2010 Dec; 19(12):2418-29. PubMed ID: 20954235
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells.
    Bockbrader KM; Tan M; Sun Y
    Oncogene; 2005 Nov; 24(49):7381-8. PubMed ID: 16044155
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.
    Nikolovska-Coleska Z; Meagher JL; Jiang S; Yang CY; Qiu S; Roller PP; Stuckey JA; Wang S
    Biochemistry; 2008 Sep; 47(37):9811-24. PubMed ID: 18717598
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.