BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

277 related articles for article (PubMed ID: 23173743)

  • 1. Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
    Torres M; Jimenez S; Sanchez-Varo R; Navarro V; Trujillo-Estrada L; Sanchez-Mejias E; Carmona I; Davila JC; Vizuete M; Gutierrez A; Vitorica J
    Mol Neurodegener; 2012 Nov; 7():59. PubMed ID: 23173743
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.
    Sanchez-Varo R; Trujillo-Estrada L; Sanchez-Mejias E; Torres M; Baglietto-Vargas D; Moreno-Gonzalez I; De Castro V; Jimenez S; Ruano D; Vizuete M; Davila JC; Garcia-Verdugo JM; Jimenez AJ; Vitorica J; Gutierrez A
    Acta Neuropathol; 2012 Jan; 123(1):53-70. PubMed ID: 22020633
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.
    Lazarov O; Lee M; Peterson DA; Sisodia SS
    J Neurosci; 2002 Nov; 22(22):9785-93. PubMed ID: 12427834
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease.
    Dutescu RM; Li QX; Crowston J; Masters CL; Baird PN; Culvenor JG
    Graefes Arch Clin Exp Ophthalmol; 2009 Sep; 247(9):1213-21. PubMed ID: 19271231
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
    Ye X; Feng T; Tammineni P; Chang Q; Jeong YY; Margolis DJ; Cai H; Kusnecov A; Cai Q
    J Neurosci; 2017 Mar; 37(10):2639-2655. PubMed ID: 28159908
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice.
    Zhou F; Xiong X; Li S; Liang J; Zhang X; Tian M; Li X; Gao M; Tang L; Li Y
    Aging (Albany NY); 2020 Jun; 12(12):12142-12159. PubMed ID: 32584265
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.
    Stokin GB; Almenar-Queralt A; Gunawardena S; Rodrigues EM; Falzone T; Kim J; Lillo C; Mount SL; Roberts EA; McGowan E; Williams DS; Goldstein LS
    Hum Mol Genet; 2008 Nov; 17(22):3474-86. PubMed ID: 18694898
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Age-related changes in hippocampal AD pathology, actin remodeling proteins and spatial memory behavior of male APP/PS1 mice.
    Sun H; Liu M; Sun T; Chen Y; Lan Z; Lian B; Zhao C; Liu Z; Zhang J; Liu Y
    Behav Brain Res; 2019 Dec; 376():112182. PubMed ID: 31472195
    [TBL] [Abstract][Full Text] [Related]  

  • 9. BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo.
    Lee EB; Zhang B; Liu K; Greenbaum EA; Doms RW; Trojanowski JQ; Lee VM
    J Cell Biol; 2005 Jan; 168(2):291-302. PubMed ID: 15642747
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Treadmill exercise enhances synaptic plasticity, but does not alter β-amyloid deposition in hippocampi of aged APP/PS1 transgenic mice.
    Zhao G; Liu HL; Zhang H; Tong XJ
    Neuroscience; 2015 Jul; 298():357-66. PubMed ID: 25917310
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.
    Lauritzen I; Pardossi-Piquard R; Bauer C; Brigham E; Abraham JD; Ranaldi S; Fraser P; St-George-Hyslop P; Le Thuc O; Espin V; Chami L; Dunys J; Checler F
    J Neurosci; 2012 Nov; 32(46):16243-1655a. PubMed ID: 23152608
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis.
    Sheng JG; Price DL; Koliatsos VE
    J Neurosci; 2002 Nov; 22(22):9794-9. PubMed ID: 12427835
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models.
    Butler D; Hwang J; Estick C; Nishiyama A; Kumar SS; Baveghems C; Young-Oxendine HB; Wisniewski ML; Charalambides A; Bahr BA
    PLoS One; 2011; 6(6):e20501. PubMed ID: 21695208
    [TBL] [Abstract][Full Text] [Related]  

  • 14. GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.
    Tian J; Shi J; Zhang L; Yin J; Hu Q; Xu Y; Sheng S; Wang P; Ren Y; Wang R; Wang Y
    Curr Alzheimer Res; 2009 Apr; 6(2):118-31. PubMed ID: 19355846
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.
    Dewachter I; Reversé D; Caluwaerts N; Ris L; Kuipéri C; Van den Haute C; Spittaels K; Umans L; Serneels L; Thiry E; Moechars D; Mercken M; Godaux E; Van Leuven F
    J Neurosci; 2002 May; 22(9):3445-53. PubMed ID: 11978821
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease.
    Pedrós I; Petrov D; Allgaier M; Sureda F; Barroso E; Beas-Zarate C; Auladell C; Pallàs M; Vázquez-Carrera M; Casadesús G; Folch J; Camins A
    Biochim Biophys Acta; 2014 Sep; 1842(9):1556-66. PubMed ID: 24887203
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.
    Lauritzen I; Pardossi-Piquard R; Bourgeois A; Pagnotta S; Biferi MG; Barkats M; Lacor P; Klein W; Bauer C; Checler F
    Acta Neuropathol; 2016 Aug; 132(2):257-276. PubMed ID: 27138984
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.
    Fukami S; Watanabe K; Iwata N; Haraoka J; Lu B; Gerard NP; Gerard C; Fraser P; Westaway D; St George-Hyslop P; Saido TC
    Neurosci Res; 2002 May; 43(1):39-56. PubMed ID: 12074840
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport.
    Sherman MA; LaCroix M; Amar F; Larson ME; Forster C; Aguzzi A; Bennett DA; Ramsden M; Lesné SE
    J Neurosci; 2016 Sep; 36(37):9647-58. PubMed ID: 27629715
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.
    Sadleir KR; Kandalepas PC; Buggia-Prévot V; Nicholson DA; Thinakaran G; Vassar R
    Acta Neuropathol; 2016 Aug; 132(2):235-256. PubMed ID: 26993139
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.