BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 23220480)

  • 1. Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation.
    Ohta E; Kawakami F; Kubo M; Obata F
    Biochem Biophys Res Commun; 2013 Jan; 430(2):560-6. PubMed ID: 23220480
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The mouse/human cross-species heterodimer of leucine-rich repeat kinase 2: possible significance in the transgenic model mouse of Parkinson's disease.
    Miyajima T; Ohta E; Kawada H; Maekawa T; Obata F
    Neurosci Lett; 2015 Feb; 588():142-6. PubMed ID: 25562633
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.
    Ohta E; Kubo M; Obata F
    Biochem Biophys Res Commun; 2010 Jan; 391(1):242-7. PubMed ID: 19912990
    [TBL] [Abstract][Full Text] [Related]  

  • 4. I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.
    Ohta E; Nihira T; Uchino A; Imaizumi Y; Okada Y; Akamatsu W; Takahashi K; Hayakawa H; Nagai M; Ohyama M; Ryo M; Ogino M; Murayama S; Takashima A; Nishiyama K; Mizuno Y; Mochizuki H; Obata F; Okano H
    Hum Mol Genet; 2015 Sep; 24(17):4879-900. PubMed ID: 26056228
    [TBL] [Abstract][Full Text] [Related]  

  • 5. LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations.
    Ohta E; Kawakami F; Kubo M; Obata F
    FEBS Lett; 2011 Jul; 585(14):2165-70. PubMed ID: 21658387
    [TBL] [Abstract][Full Text] [Related]  

  • 6. LRRK2 I2020T mutation is associated with tau pathology.
    Ujiie S; Hatano T; Kubo S; Imai S; Sato S; Uchihara T; Yagishita S; Hasegawa K; Kowa H; Sakai F; Hattori N
    Parkinsonism Relat Disord; 2012 Aug; 18(7):819-23. PubMed ID: 22525366
    [TBL] [Abstract][Full Text] [Related]  

  • 7. I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.
    Ohta E; Katayama Y; Kawakami F; Yamamoto M; Tajima K; Maekawa T; Iida N; Hattori S; Obata F
    Biochem Biophys Res Commun; 2009 Dec; 390(3):710-5. PubMed ID: 19833102
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation.
    Greene ID; Mastaglia F; Meloni BP; West KA; Chieng J; Mitchell CJ; Gai WP; Boulos S
    J Neurosci Res; 2014 Apr; 92(4):506-16. PubMed ID: 24375786
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.
    Gloeckner CJ; Kinkl N; Schumacher A; Braun RJ; O'Neill E; Meitinger T; Kolch W; Prokisch H; Ueffing M
    Hum Mol Genet; 2006 Jan; 15(2):223-32. PubMed ID: 16321986
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation.
    Kamikawaji S; Ito G; Sano T; Iwatsubo T
    Biochemistry; 2013 Sep; 52(35):6052-62. PubMed ID: 23924436
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes.
    Leandrou E; Markidi E; Memou A; Melachroinou K; Greggio E; Rideout HJ
    Biochem J; 2019 Feb; 476(3):559-579. PubMed ID: 30670570
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.
    Ray S; Bender S; Kang S; Lin R; Glicksman MA; Liu M
    J Biol Chem; 2014 May; 289(19):13042-53. PubMed ID: 24695735
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity.
    Reichling LJ; Riddle SM
    Biochem Biophys Res Commun; 2009 Jun; 384(2):255-8. PubMed ID: 19397894
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.
    Tsika E; Nguyen AP; Dusonchet J; Colin P; Schneider BL; Moore DJ
    Neurobiol Dis; 2015 May; 77():49-61. PubMed ID: 25731749
    [TBL] [Abstract][Full Text] [Related]  

  • 15. LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.
    Heo HY; Park JM; Kim CH; Han BS; Kim KS; Seol W
    Exp Cell Res; 2010 Feb; 316(4):649-56. PubMed ID: 19769964
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
    Sheng Z; Zhang S; Bustos D; Kleinheinz T; Le Pichon CE; Dominguez SL; Solanoy HO; Drummond J; Zhang X; Ding X; Cai F; Song Q; Li X; Yue Z; van der Brug MP; Burdick DJ; Gunzner-Toste J; Chen H; Liu X; Estrada AA; Sweeney ZK; Scearce-Levie K; Moffat JG; Kirkpatrick DS; Zhu H
    Sci Transl Med; 2012 Dec; 4(164):164ra161. PubMed ID: 23241745
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Leucine-rich repeat kinase 2 associates with lipid rafts.
    Hatano T; Kubo S; Imai S; Maeda M; Ishikawa K; Mizuno Y; Hattori N
    Hum Mol Genet; 2007 Mar; 16(6):678-90. PubMed ID: 17341485
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities.
    Maekawa T; Mori S; Sasaki Y; Miyajima T; Azuma S; Ohta E; Obata F
    Mol Neurodegener; 2012 Apr; 7():15. PubMed ID: 22534020
    [TBL] [Abstract][Full Text] [Related]  

  • 19. G2385R and I2020T Mutations Increase LRRK2 GTPase Activity.
    Ho DH; Jang J; Joe EH; Son I; Seo H; Seol W
    Biomed Res Int; 2016; 2016():7917128. PubMed ID: 27314038
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.
    Tomiyama H; Li Y; Funayama M; Hasegawa K; Yoshino H; Kubo S; Sato K; Hattori T; Lu CS; Inzelberg R; Djaldetti R; Melamed E; Amouri R; Gouider-Khouja N; Hentati F; Hatano Y; Wang M; Imamichi Y; Mizoguchi K; Miyajima H; Obata F; Toda T; Farrer MJ; Mizuno Y; Hattori N
    Mov Disord; 2006 Aug; 21(8):1102-8. PubMed ID: 16622854
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.