BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

180 related articles for article (PubMed ID: 23227217)

  • 1. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
    Heise CE; Murray J; Augustyn KE; Bravo B; Chugha P; Cohen F; Giannetti AM; Gibbons P; Hannoush RN; Hearn BR; Jaishankar P; Ly CQ; Shah K; Stanger K; Steffek M; Tang Y; Zhao X; Lewcock JW; Renslo AR; Flygare J; Arkin MR
    PLoS One; 2012; 7(12):e50864. PubMed ID: 23227217
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of Allosteric Inhibitors against Active Caspase-6.
    Tubeleviciute-Aydin A; Beautrait A; Lynham J; Sharma G; Gorelik A; Deny LJ; Soya N; Lukacs GL; Nagar B; Marinier A; LeBlanc AC
    Sci Rep; 2019 Apr; 9(1):5504. PubMed ID: 30940883
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Specific inhibition of caspase-3 by a competitive DARPin: molecular mimicry between native and designed inhibitors.
    Schroeder T; Barandun J; Flütsch A; Briand C; Mittl PR; Grütter MG
    Structure; 2013 Feb; 21(2):277-89. PubMed ID: 23333429
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A class of allosteric caspase inhibitors identified by high-throughput screening.
    Feldman T; Kabaleeswaran V; Jang SB; Antczak C; Djaballah H; Wu H; Jiang X
    Mol Cell; 2012 Aug; 47(4):585-95. PubMed ID: 22795132
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition.
    Fang B; Boross PI; Tozser J; Weber IT
    J Mol Biol; 2006 Jul; 360(3):654-66. PubMed ID: 16781734
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C.
    Mintzer R; Ramaswamy S; Shah K; Hannoush RN; Pozniak CD; Cohen F; Zhao X; Plise E; Lewcock JW; Heise CE
    PLoS One; 2012; 7(1):e30376. PubMed ID: 22253931
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.
    Ekici OD; Li ZZ; Campbell AJ; James KE; Asgian JL; Mikolajczyk J; Salvesen GS; Ganesan R; Jelakovic S; Grütter MG; Powers JC
    J Med Chem; 2006 Sep; 49(19):5728-49. PubMed ID: 16970398
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids.
    Vickers CJ; González-Páez GE; Litwin KM; Umotoy JC; Coutsias EA; Wolan DW
    ACS Chem Biol; 2014 Oct; 9(10):2194-8. PubMed ID: 25079698
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling.
    Fang B; Fu G; Agniswamy J; Harrison RW; Weber IT
    Apoptosis; 2009 May; 14(5):741-52. PubMed ID: 19283487
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Activation and regulation of caspase-6 and its role in neurodegenerative diseases.
    Wang XJ; Cao Q; Zhang Y; Su XD
    Annu Rev Pharmacol Toxicol; 2015; 55():553-72. PubMed ID: 25340928
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of the novel substrates for caspase-6 in apoptosis using proteomic approaches.
    Cho JH; Lee PY; Son WC; Chi SW; Park BC; Kim JH; Park SG
    BMB Rep; 2013 Dec; 46(12):588-93. PubMed ID: 24195789
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Caspase selective reagents for diagnosing apoptotic mechanisms.
    Poreba M; Groborz K; Navarro M; Snipas SJ; Drag M; Salvesen GS
    Cell Death Differ; 2019 Feb; 26(2):229-244. PubMed ID: 29748600
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.
    Stanger K; Steffek M; Zhou L; Pozniak CD; Quan C; Franke Y; Tom J; Tam C; Krylova I; Elliott JM; Lewcock JW; Zhang Y; Murray J; Hannoush RN
    Nat Chem Biol; 2012 Jul; 8(7):655-60. PubMed ID: 22683611
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Multi-Pharmacophore Modeling of Caspase-3 Inhibitors using Crystal, Dock and Flexible Conformation Schemes.
    Kumar SP; Jha PC
    Comb Chem High Throughput Screen; 2018; 21(1):26-40. PubMed ID: 29295689
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development.
    Maillard MC; Dominguez C; Gemkow MJ; Krieger F; Park H; Schaertl S; Winkler D; Muñoz-Sanjuán I
    J Biomol Screen; 2013 Sep; 18(8):868-78. PubMed ID: 23796689
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
    Vucic D; Franklin MC; Wallweber HJ; Das K; Eckelman BP; Shin H; Elliott LO; Kadkhodayan S; Deshayes K; Salvesen GS; Fairbrother WJ
    Biochem J; 2005 Jan; 385(Pt 1):11-20. PubMed ID: 15485396
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.
    Velázquez-Delgado EM; Hardy JA
    Structure; 2012 Apr; 20(4):742-51. PubMed ID: 22483120
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening.
    Brantley SJ; Cotten SW; Lamson DR; Smith GR; Liu R; Williams KP
    Biochem Biophys Res Commun; 2017 Sep; 491(3):773-779. PubMed ID: 28733033
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.
    Wei Y; Fox T; Chambers SP; Sintchak J; Coll JT; Golec JM; Swenson L; Wilson KP; Charifson PS
    Chem Biol; 2000 Jun; 7(6):423-32. PubMed ID: 10873833
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 'Polymorphism-aided' Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment.
    Kumi RO; Agoni C; Issahaku AR; Olotu FA; Soliman MES
    Cell Biochem Biophys; 2020 Sep; 78(3):291-299. PubMed ID: 32592127
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.