These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Smolková K; Dvořák A; Zelenka J; Vítek L; Ježek P Int J Biochem Cell Biol; 2015 Aug; 65():125-33. PubMed ID: 26007236 [TBL] [Abstract][Full Text] [Related]
4. 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. Jin G; Reitman ZJ; Spasojevic I; Batinic-Haberle I; Yang J; Schmidt-Kittler O; Bigner DD; Yan H PLoS One; 2011 Feb; 6(2):e16812. PubMed ID: 21326614 [TBL] [Abstract][Full Text] [Related]
5. Isocitrate dehydrogenase gene mutations and 2-hydroxyglutarate accumulation in esophageal squamous cell carcinoma. Miyake K; Baba Y; Ishimoto T; Hiyoshi Y; Iwatsuki M; Miyamoto Y; Yoshida N; Watanabe M; Ogata Y; Nagayama M; Silsirivanit A; Kobayashi D; Araki N; Baba H Med Oncol; 2018 Nov; 36(1):11. PubMed ID: 30506321 [TBL] [Abstract][Full Text] [Related]
6. Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d-2-hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma. Mohammad N; Wong D; Lum A; Lin J; Ho J; Lee CH; Yip S Histopathology; 2020 Apr; 76(5):722-730. PubMed ID: 31609487 [TBL] [Abstract][Full Text] [Related]
7. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Ward PS; Patel J; Wise DR; Abdel-Wahab O; Bennett BD; Coller HA; Cross JR; Fantin VR; Hedvat CV; Perl AE; Rabinowitz JD; Carroll M; Su SM; Sharp KA; Levine RL; Thompson CB Cancer Cell; 2010 Mar; 17(3):225-34. PubMed ID: 20171147 [TBL] [Abstract][Full Text] [Related]
8. The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development. Lemonnier F; Cairns RA; Inoue S; Li WY; Dupuy A; Broutin S; Martin N; Fataccioli V; Pelletier R; Wakeham A; Snow BE; de Leval L; Pujals A; Haioun C; Paci A; Tobin ER; Narayanaswamy R; Yen K; Jin S; Gaulard P; Mak TW Proc Natl Acad Sci U S A; 2016 Dec; 113(52):15084-15089. PubMed ID: 27956631 [TBL] [Abstract][Full Text] [Related]
9. Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia. Brunner AM; Neuberg DS; Wander SA; Sadrzadeh H; Ballen KK; Amrein PC; Attar E; Hobbs GS; Chen YB; Perry A; Connolly C; Joseph C; Burke M; Ramos A; Galinsky I; Yen K; Yang H; Straley K; Agresta S; Adamia S; Borger DR; Iafrate A; Graubert TA; Stone RM; Fathi AT Cancer; 2019 Feb; 125(4):541-549. PubMed ID: 30422308 [TBL] [Abstract][Full Text] [Related]
10. Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas. Jin G; Reitman ZJ; Duncan CG; Spasojevic I; Gooden DM; Rasheed BA; Yang R; Lopez GY; He Y; McLendon RE; Bigner DD; Yan H Cancer Res; 2013 Jan; 73(2):496-501. PubMed ID: 23204232 [TBL] [Abstract][Full Text] [Related]
11. IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells. Matsunaga H; Futakuchi-Tsuchida A; Takahashi M; Ishikawa T; Tsuji M; Ando O Biochem Biophys Res Commun; 2012 Jul; 423(3):553-6. PubMed ID: 22683334 [TBL] [Abstract][Full Text] [Related]
12. Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells. Li L; Paz AC; Wilky BA; Johnson B; Galoian K; Rosenberg A; Hu G; Tinoco G; Bodamer O; Trent JC PLoS One; 2015; 10(9):e0133813. PubMed ID: 26368816 [TBL] [Abstract][Full Text] [Related]
13. Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. Intlekofer AM; Shih AH; Wang B; Nazir A; Rustenburg AS; Albanese SK; Patel M; Famulare C; Correa FM; Takemoto N; Durani V; Liu H; Taylor J; Farnoud N; Papaemmanuil E; Cross JR; Tallman MS; Arcila ME; Roshal M; Petsko GA; Wu B; Choe S; Konteatis ZD; Biller SA; Chodera JD; Thompson CB; Levine RL; Stein EM Nature; 2018 Jul; 559(7712):125-129. PubMed ID: 29950729 [TBL] [Abstract][Full Text] [Related]
14. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Akbay EA; Moslehi J; Christensen CL; Saha S; Tchaicha JH; Ramkissoon SH; Stewart KM; Carretero J; Kikuchi E; Zhang H; Cohoon TJ; Murray S; Liu W; Uno K; Fisch S; Jones K; Gurumurthy S; Gliser C; Choe S; Keenan M; Son J; Stanley I; Losman JA; Padera R; Bronson RT; Asara JM; Abdel-Wahab O; Amrein PC; Fathi AT; Danial NN; Kimmelman AC; Kung AL; Ligon KL; Yen KE; Kaelin WG; Bardeesy N; Wong KK Genes Dev; 2014 Mar; 28(5):479-90. PubMed ID: 24589777 [TBL] [Abstract][Full Text] [Related]
15. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Dang L; White DW; Gross S; Bennett BD; Bittinger MA; Driggers EM; Fantin VR; Jang HG; Jin S; Keenan MC; Marks KM; Prins RM; Ward PS; Yen KE; Liau LM; Rabinowitz JD; Cantley LC; Thompson CB; Vander Heiden MG; Su SM Nature; 2009 Dec; 462(7274):739-44. PubMed ID: 19935646 [TBL] [Abstract][Full Text] [Related]
16. Isocitrate Dehydrogenase Mutations in Cancer: Mechanisms of Transformation and Metabolic Liability. Gunn K; Losman JA Cold Spring Harb Perspect Med; 2024 May; 14(5):. PubMed ID: 38191174 [TBL] [Abstract][Full Text] [Related]
17. Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila. Reitman ZJ; Sinenko SA; Spana EP; Yan H Blood; 2015 Jan; 125(2):336-45. PubMed ID: 25398939 [TBL] [Abstract][Full Text] [Related]
18. Low pH Facilitates Heterodimerization of Mutant Isocitrate Dehydrogenase IDH1-R132H and Promotes Production of 2-Hydroxyglutarate. Sesanto R; Kuehn JF; Barber DL; White KA Biochemistry; 2021 Jun; 60(25):1983-1994. PubMed ID: 34143606 [TBL] [Abstract][Full Text] [Related]
19. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. Badur MG; Muthusamy T; Parker SJ; Ma S; McBrayer SK; Cordes T; Magana JH; Guan KL; Metallo CM Cell Rep; 2018 Oct; 25(4):1018-1026.e4. PubMed ID: 30355481 [TBL] [Abstract][Full Text] [Related]