BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 23269235)

  • 1. Inhibition of autophagy enhances sunitinib-induced cytotoxicity in rat pheochromocytoma PC12 cells.
    Ikeda T; Ishii KA; Saito Y; Miura M; Otagiri A; Kawakami Y; Shimano H; Hara H; Takekoshi K
    J Pharmacol Sci; 2013; 121(1):67-73. PubMed ID: 23269235
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD.
    Saito Y; Tanaka Y; Aita Y; Ishii KA; Ikeda T; Isobe K; Kawakami Y; Shimano H; Hara H; Takekoshi K
    Am J Physiol Endocrinol Metab; 2012 Mar; 302(6):E615-25. PubMed ID: 21878661
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sunitinib inhibits catecholamine synthesis and secretion in pheochromocytoma tumor cells by blocking VEGF receptor 2 via PLC-γ-related pathways.
    Aita Y; Ishii KA; Saito Y; Ikeda T; Kawakami Y; Shimano H; Hara H; Takekoshi K
    Am J Physiol Endocrinol Metab; 2012 Oct; 303(8):E1006-14. PubMed ID: 22912364
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.
    Hosokawa N; Hara T; Kaizuka T; Kishi C; Takamura A; Miura Y; Iemura S; Natsume T; Takehana K; Yamada N; Guan JL; Oshiro N; Mizushima N
    Mol Biol Cell; 2009 Apr; 20(7):1981-91. PubMed ID: 19211835
    [TBL] [Abstract][Full Text] [Related]  

  • 5. mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex.
    Chan EY
    Sci Signal; 2009 Aug; 2(84):pe51. PubMed ID: 19690328
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Both sunitinib and sorafenib are effective treatments for pheochromocytoma in a xenograft model.
    Denorme M; Yon L; Roux C; Gonzalez BJ; Baudin E; Anouar Y; Dubessy C
    Cancer Lett; 2014 Oct; 352(2):236-44. PubMed ID: 25016061
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas.
    Cassol CA; Winer D; Liu W; Guo M; Ezzat S; Asa SL
    Mod Pathol; 2014 Aug; 27(8):1050-62. PubMed ID: 24390213
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Interferon alpha and rapamycin inhibit the growth of pheochromocytoma PC12 line in vitro.
    Motylewska E; Lawnicka H; Kowalewicz-Kulbat M; Sicinska P; Niedziela A; Melen-Mucha G; Stepien H
    Endokrynol Pol; 2013; 64(5):368-74. PubMed ID: 24186594
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeting of mTORC2 may have advantages over selective targeting of mTORC1 in the treatment of malignant pheochromocytoma.
    Zhang X; Wang X; Xu T; Zhong S; Shen Z
    Tumour Biol; 2015 Jul; 36(7):5273-81. PubMed ID: 25666752
    [TBL] [Abstract][Full Text] [Related]  

  • 10. [Sunitinib induces autophagy via suppressing Akt/mTOR pathway in renal cell carcinoma].
    Cao P; Jiang XJ; Xi ZJ
    Beijing Da Xue Xue Bao Yi Xue Ban; 2016 Aug; 48(4):584-589. PubMed ID: 29263493
    [TBL] [Abstract][Full Text] [Related]  

  • 11. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.
    Jung CH; Jun CB; Ro SH; Kim YM; Otto NM; Cao J; Kundu M; Kim DH
    Mol Biol Cell; 2009 Apr; 20(7):1992-2003. PubMed ID: 19225151
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction.
    Alers S; Löffler AS; Paasch F; Dieterle AM; Keppeler H; Lauber K; Campbell DG; Fehrenbacher B; Schaller M; Wesselborg S; Stork B
    Autophagy; 2011 Dec; 7(12):1423-33. PubMed ID: 22024743
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model.
    Zhang X; Wang X; Qin L; Xu T; Zhu Z; Zhong S; Zhang M; Shen Z
    Urology; 2015 Jan; 85(1):273.e1-7. PubMed ID: 25440763
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.
    Ganley IG; Lam du H; Wang J; Ding X; Chen S; Jiang X
    J Biol Chem; 2009 May; 284(18):12297-305. PubMed ID: 19258318
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.
    Park JM; Jung CH; Seo M; Otto NM; Grunwald D; Kim KH; Moriarity B; Kim YM; Starker C; Nho RS; Voytas D; Kim DH
    Autophagy; 2016; 12(3):547-64. PubMed ID: 27046250
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib.
    Serova M; de Gramont A; Tijeras-Raballand A; Dos Santos C; Riveiro ME; Slimane K; Faivre S; Raymond E
    Cancer Chemother Pharmacol; 2013 May; 71(5):1297-307. PubMed ID: 23479136
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Systematic combination screening reveals synergism between rapamycin and sunitinib against human lung cancer.
    Li X; Tong LJ; Ding J; Meng LH
    Cancer Lett; 2014 Jan; 342(1):159-66. PubMed ID: 24018642
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling.
    Ikezoe T; Nishioka C; Tasaka T; Yang Y; Komatsu N; Togitani K; Koeffler HP; Taguchi H
    Mol Cancer Ther; 2006 Oct; 5(10):2522-30. PubMed ID: 17041096
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PDK1 Inhibitor GSK-470 Exhibits Potent Anticancer Activity in a Pheochromocytoma PC12 Cell Tumor Model via Akt/mTOR Pathway.
    Zhang X; Zhong S
    Anticancer Agents Med Chem; 2020; 20(7):828-833. PubMed ID: 32188393
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin.
    Huang Y; Xi Q; Chen Y; Wang J; Peng P; Xia S; Yu S
    Anticancer Drugs; 2013 Oct; 24(9):889-98. PubMed ID: 23838676
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.