273 related articles for article (PubMed ID: 23291095)
1. γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.
Okochi M; Tagami S; Yanagida K; Takami M; Kodama TS; Mori K; Nakayama T; Ihara Y; Takeda M
Cell Rep; 2013 Jan; 3(1):42-51. PubMed ID: 23291095
[TBL] [Abstract][Full Text] [Related]
2. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
Czirr E; Cottrell BA; Leuchtenberger S; Kukar T; Ladd TB; Esselmann H; Paul S; Schubenel R; Torpey JW; Pietrzik CU; Golde TE; Wiltfang J; Baumann K; Koo EH; Weggen S
J Biol Chem; 2008 Jun; 283(25):17049-54. PubMed ID: 18426795
[TBL] [Abstract][Full Text] [Related]
3. γ-Secretase modulator in Alzheimer's disease: shifting the end.
Xia W; Wong ST; Hanlon E; Morin P
J Alzheimers Dis; 2012; 31(4):685-96. PubMed ID: 22710916
[TBL] [Abstract][Full Text] [Related]
4. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.
Fernandez MA; Klutkowski JA; Freret T; Wolfe MS
J Biol Chem; 2014 Nov; 289(45):31043-52. PubMed ID: 25239621
[TBL] [Abstract][Full Text] [Related]
5. Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides.
Cam M; Durieu E; Bodin M; Manousopoulou A; Koslowski S; Vasylieva N; Barnych B; Hammock BD; Bohl B; Koch P; Omori C; Yamamoto K; Hata S; Suzuki T; Karg F; Gizzi P; Erakovic Haber V; Bencetic Mihaljevic V; Tavcar B; Portelius E; Pannee J; Blennow K; Zetterberg H; Garbis SD; Auvray P; Gerber H; Fraering J; Fraering PC; Meijer L
J Alzheimers Dis; 2018; 62(4):1663-1681. PubMed ID: 29504531
[TBL] [Abstract][Full Text] [Related]
6. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
Kretner B; Fukumori A; Kuhn PH; Pérez-Revuelta BI; Lichtenthaler SF; Haass C; Steiner H
J Neurochem; 2013 Apr; 125(1):144-56. PubMed ID: 23237322
[TBL] [Abstract][Full Text] [Related]
7. Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
Blain JF; Bursavich MG; Freeman EA; Hrdlicka LA; Hodgdon HE; Chen T; Costa DE; Harrison BA; Kapadnis S; Murphy DA; Nolan S; Tu Z; Tang C; Burnett DA; Patzke H; Koenig G
Alzheimers Res Ther; 2016 Aug; 8(1):34. PubMed ID: 27572246
[TBL] [Abstract][Full Text] [Related]
8. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
[TBL] [Abstract][Full Text] [Related]
9. Purification and characterization of the human gamma-secretase complex.
Fraering PC; Ye W; Strub JM; Dolios G; LaVoie MJ; Ostaszewski BL; van Dorsselaer A; Wang R; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Aug; 43(30):9774-89. PubMed ID: 15274632
[TBL] [Abstract][Full Text] [Related]
10. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
[TBL] [Abstract][Full Text] [Related]
11. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
[TBL] [Abstract][Full Text] [Related]
12. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
Liu L; Lauro BM; Wolfe MS; Selkoe DJ
J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
[TBL] [Abstract][Full Text] [Related]
13. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.
Czirr E; Leuchtenberger S; Dorner-Ciossek C; Schneider A; Jucker M; Koo EH; Pietrzik CU; Baumann K; Weggen S
J Biol Chem; 2007 Aug; 282(34):24504-13. PubMed ID: 17573346
[TBL] [Abstract][Full Text] [Related]
14. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
Shimojo M; Sahara N; Mizoroki T; Funamoto S; Morishima-Kawashima M; Kudo T; Takeda M; Ihara Y; Ichinose H; Takashima A
J Biol Chem; 2008 Jun; 283(24):16488-96. PubMed ID: 18430735
[TBL] [Abstract][Full Text] [Related]
15. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
[TBL] [Abstract][Full Text] [Related]
16. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
17. Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
Zettl H; Ness J; Hähnke V; Beher D; Jumpertz T; Saric A; Baumann K; Pietrzik CU; Bulic B; Schneider G; Weggen S
ACS Chem Biol; 2012 Sep; 7(9):1488-95. PubMed ID: 22725102
[TBL] [Abstract][Full Text] [Related]
18. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
Winkler E; Hobson S; Fukumori A; Dümpelfeld B; Luebbers T; Baumann K; Haass C; Hopf C; Steiner H
Biochemistry; 2009 Feb; 48(6):1183-97. PubMed ID: 19159235
[TBL] [Abstract][Full Text] [Related]
19. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
Heilig EA; Xia W; Shen J; Kelleher RJ
J Biol Chem; 2010 Jul; 285(29):22350-9. PubMed ID: 20460383
[TBL] [Abstract][Full Text] [Related]
20. Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease.
Svedružić ZM; Popović K; Smoljan I; Sendula-Jengić V
PLoS One; 2012; 7(3):e32293. PubMed ID: 22479317
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
