These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

254 related articles for article (PubMed ID: 23296088)

  • 1. A new model for allosteric regulation of phenylalanine hydroxylase: implications for disease and therapeutics.
    Jaffe EK; Stith L; Lawrence SH; Andrake M; Dunbrack RL
    Arch Biochem Biophys; 2013 Feb; 530(2):73-82. PubMed ID: 23296088
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Simulations of the regulatory ACT domain of human phenylalanine hydroxylase (PAH) unveil its mechanism of phenylalanine binding.
    Ge Y; Borne E; Stewart S; Hansen MR; Arturo EC; Jaffe EK; Voelz VA
    J Biol Chem; 2018 Dec; 293(51):19532-19543. PubMed ID: 30287685
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Manipulation of a cation-π sandwich reveals conformational flexibility in phenylalanine hydroxylase.
    Arturo EC; Merkel GW; Hansen MR; Lisowski S; Almeida D; Gupta K; Jaffe EK
    Biochimie; 2021 Apr; 183():63-77. PubMed ID: 33221376
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium.
    Arturo EC; Gupta K; Hansen MR; Borne E; Jaffe EK
    J Biol Chem; 2019 Jun; 294(26):10131-10145. PubMed ID: 31076506
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain.
    Patel D; Kopec J; Fitzpatrick F; McCorvie TJ; Yue WW
    Sci Rep; 2016 Apr; 6():23748. PubMed ID: 27049649
    [TBL] [Abstract][Full Text] [Related]  

  • 6. New protein structures provide an updated understanding of phenylketonuria.
    Jaffe EK
    Mol Genet Metab; 2017 Aug; 121(4):289-296. PubMed ID: 28645531
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Loss of function in phenylketonuria is caused by impaired molecular motions and conformational instability.
    Gersting SW; Kemter KF; Staudigl M; Messing DD; Danecka MK; Lagler FB; Sommerhoff CP; Roscher AA; Muntau AC
    Am J Hum Genet; 2008 Jul; 83(1):5-17. PubMed ID: 18538294
    [TBL] [Abstract][Full Text] [Related]  

  • 8. First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer.
    Arturo EC; Gupta K; Héroux A; Stith L; Cross PJ; Parker EJ; Loll PJ; Jaffe EK
    Proc Natl Acad Sci U S A; 2016 Mar; 113(9):2394-9. PubMed ID: 26884182
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of the Allosteric Site for Phenylalanine in Rat Phenylalanine Hydroxylase.
    Zhang S; Fitzpatrick PF
    J Biol Chem; 2016 Apr; 291(14):7418-25. PubMed ID: 26823465
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phenylalanine hydroxylase misfolding and pharmacological chaperones.
    Underhaug J; Aubi O; Martinez A
    Curr Top Med Chem; 2012; 12(22):2534-45. PubMed ID: 23339306
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin.
    Flydal MI; Alcorlo-Pagés M; Johannessen FG; Martínez-Caballero S; Skjærven L; Fernandez-Leiro R; Martinez A; Hermoso JA
    Proc Natl Acad Sci U S A; 2019 Jun; 116(23):11229-11234. PubMed ID: 31118288
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Towards the identification of the allosteric Phe-binding site in phenylalanine hydroxylase.
    Carluccio C; Fraternali F; Salvatore F; Fornili A; Zagari A
    J Biomol Struct Dyn; 2016; 34(3):497-507. PubMed ID: 26479306
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability.
    Khan CA; Meisburger SP; Ando N; Fitzpatrick PF
    J Biol Chem; 2019 Mar; 294(12):4359-4367. PubMed ID: 30674554
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural interpretation of mutations in phenylalanine hydroxylase protein aids in identifying genotype-phenotype correlations in phenylketonuria.
    Jennings IG; Cotton RG; Kobe B
    Eur J Hum Genet; 2000 Sep; 8(9):683-96. PubMed ID: 10980574
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Unravelling the Complex Denaturant and Thermal-Induced Unfolding Equilibria of Human Phenylalanine Hydroxylase.
    Conde-Giménez M; Sancho J
    Int J Mol Sci; 2021 Jun; 22(12):. PubMed ID: 34207146
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The G46S-hPAH mutant protein: a model to study the rescue of aggregation-prone PKU mutations by chaperones.
    Leandro J; Saraste J; Leandro P; Flatmark T
    Mol Genet Metab; 2011; 104 Suppl():S40-4. PubMed ID: 21871828
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phenylketonuria as a protein misfolding disease: The mutation pG46S in phenylalanine hydroxylase promotes self-association and fibril formation.
    Leandro J; Simonsen N; Saraste J; Leandro P; Flatmark T
    Biochim Biophys Acta; 2011 Jan; 1812(1):106-20. PubMed ID: 20937381
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Amino Acid Specificity for Activation of Phenylalanine Hydroxylase Matches the Specificity for Stabilization of Regulatory Domain Dimers.
    Zhang S; Hinck AP; Fitzpatrick PF
    Biochemistry; 2015 Aug; 54(33):5167-74. PubMed ID: 26252467
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase.
    Gámez A; Wang L; Straub M; Patch MG; Stevens RC
    Mol Ther; 2004 Jan; 9(1):124-9. PubMed ID: 14741785
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of phenylalanine hydroxylase induces positive cooperativity toward the natural cofactor.
    Gersting SW; Staudigl M; Truger MS; Messing DD; Danecka MK; Sommerhoff CP; Kemter KF; Muntau AC
    J Biol Chem; 2010 Oct; 285(40):30686-97. PubMed ID: 20667834
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.