BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 23311288)

  • 1. Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine.
    Zhu R; Baumann RP; Penketh PG; Shyam K; Sartorelli AC
    J Med Chem; 2013 Feb; 56(3):1355-9. PubMed ID: 23311288
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase.
    Zhu R; Seow HA; Baumann RP; Ishiguro K; Penketh PG; Shyam K; Sartorelli AC
    Bioorg Med Chem Lett; 2012 Oct; 22(19):6242-7. PubMed ID: 22932317
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.
    Penketh PG; Shyam K; Baumann RP; Ishiguro K; Patridge EV; Zhu R; Sartorelli AC
    Chem Biol Drug Des; 2012 Aug; 80(2):279-90. PubMed ID: 22553921
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.
    Zhu R; Liu MC; Luo MZ; Penketh PG; Baumann RP; Shyam K; Sartorelli AC
    J Med Chem; 2011 Nov; 54(21):7720-8. PubMed ID: 21955333
    [TBL] [Abstract][Full Text] [Related]  

  • 5. O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
    Dolan ME; Roy SK; Garbiras BJ; Helft P; Paras P; Chae MY; Moschel RC; Pegg AE
    Biochem Pharmacol; 1998 May; 55(10):1701-9. PubMed ID: 9634007
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.
    Griffin RJ; Arris CE; Bleasdale C; Boyle FT; Calvert AH; Curtin NJ; Dalby C; Kanugula S; Lembicz NK; Newell DR; Pegg AE; Golding BT
    J Med Chem; 2000 Nov; 43(22):4071-83. PubMed ID: 11063604
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.
    Chae MY; Swenn K; Kanugula S; Dolan ME; Pegg AE; Moschel RC
    J Med Chem; 1995 Jan; 38(2):359-65. PubMed ID: 7830279
    [TBL] [Abstract][Full Text] [Related]  

  • 8. NBGNU: a hypoxia-activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemoresistance.
    Ge Y; Lai X; Li J; Yu R; Zhuang Z; Sun G; Cui X; Zhang N; Zhao L; Upadhyaya P; Zhong R
    Future Med Chem; 2019 Feb; 11(4):269-284. PubMed ID: 30560688
    [No Abstract]   [Full Text] [Related]  

  • 9. Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.
    Pauly GT; Loktionova NA; Fang Q; Vankayala SL; Guida WC; Pegg AE
    J Med Chem; 2008 Nov; 51(22):7144-53. PubMed ID: 18973327
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Depletion of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine in three-dimensional collagen cultures of normal human breast epithelial cells.
    Hamdan MA; Guzman RC; Yang J; Beattie C; Mascharack P; Nandi S
    Carcinogenesis; 1992 Oct; 13(10):1743-9. PubMed ID: 1423833
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.
    McElhinney RS; Donnelly DJ; McCormick JE; Kelly J; Watson AJ; Rafferty JA; Elder RH; Middleton MR; Willington MA; McMurry TB; Margison GP
    J Med Chem; 1998 Dec; 41(26):5265-71. PubMed ID: 9857094
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine.
    Xu-Welliver M; Kanugula S; Pegg AE
    Cancer Res; 1998 May; 58(9):1936-45. PubMed ID: 9581836
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.
    Xu-Welliver M; Leitão J; Kanugula S; Pegg AE
    Cancer Res; 1999 Apr; 59(7):1514-9. PubMed ID: 10197622
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Reductive Activity and Mechanism of Hypoxia- Targeted AGT Inhibitors: An Experimental and Theoretical Investigation.
    Xiao W; Sun G; Fan T; Liu J; Zhang N; Zhao L; Zhong R
    Int J Mol Sci; 2019 Dec; 20(24):. PubMed ID: 31847200
    [TBL] [Abstract][Full Text] [Related]  

  • 15. [Mutation of human O6-alkylguanine-DNA alkyltransferase confers resistance to O6-benzylguanine].
    Wan Y; Wu D; Gao H
    Zhonghua Zhong Liu Za Zhi; 2000 Jul; 22(4):290-3. PubMed ID: 11778552
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
    Loktionova NA; Xu-Welliver M; Crone TM; Kanugula S; Pegg AE
    Biochem Pharmacol; 1999 Jul; 58(2):237-44. PubMed ID: 10423163
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.
    Xu-Welliver M; Leitão J; Kanugula S; Meehan WJ; Pegg AE
    Biochem Pharmacol; 1999 Oct; 58(8):1279-85. PubMed ID: 10487529
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inactivation of O6-alkylguanine-DNA alkyltransferase by 8-substituted O6-benzylguanine analogs in mice.
    Ewesuedo RB; Wilson LR; Friedman HS; Moschel RC; Dolan ME
    Cancer Chemother Pharmacol; 2001; 47(1):63-9. PubMed ID: 11221964
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
    Loktionova NA; Pegg AE
    Cancer Res; 1996 Apr; 56(7):1578-83. PubMed ID: 8603405
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides.
    Pegg AE; Kanugula S; Edara S; Pauly GT; Moschel RC; Goodtzova K
    J Biol Chem; 1998 May; 273(18):10863-7. PubMed ID: 9556560
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.