146 related articles for article (PubMed ID: 23317570)
1. Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
Ting PC; Lee JF; Zorn N; Kim HM; Aslanian RG; Lin M; Smith M; Walker SS; Cook J; Van Heek M; Lachowicz J
Bioorg Med Chem Lett; 2013 Feb; 23(4):985-8. PubMed ID: 23317570
[TBL] [Abstract][Full Text] [Related]
2. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.
Qian Y; Wertheimer SJ; Ahmad M; Cheung AW; Firooznia F; Hamilton MM; Hayden S; Li S; Marcopulos N; McDermott L; Tan J; Yun W; Guo L; Pamidimukkala A; Chen Y; Huang KS; Ramsey GB; Whittard T; Conde-Knape K; Taub R; Rondinone CM; Tilley J; Bolin D
J Med Chem; 2011 Apr; 54(7):2433-46. PubMed ID: 21413799
[TBL] [Abstract][Full Text] [Related]
3. Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors.
Lee K; Goo JI; Jung HY; Kim M; Boovanahalli SK; Park HR; Kim MO; Kim DH; Lee HS; Choi Y
Bioorg Med Chem Lett; 2012 Dec; 22(24):7456-60. PubMed ID: 23141914
[TBL] [Abstract][Full Text] [Related]
4. Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.
Zhou G; Ting PC; Wishart G; Zorn N; Aslanian RG; Lin M; Smith M; Walker SS; Cook J; Van Heek M; Lachowicz J
Bioorg Med Chem Lett; 2014 Apr; 24(7):1790-4. PubMed ID: 24618302
[TBL] [Abstract][Full Text] [Related]
5. Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors.
Yun W; Ahmad M; Chen Y; Gillespie P; Conde-Knape K; Kazmer S; Li S; Qian Y; Taub R; Wertheimer SJ; Whittard T; Bolin D
Bioorg Med Chem Lett; 2011 Dec; 21(23):7205-9. PubMed ID: 22001092
[TBL] [Abstract][Full Text] [Related]
6. Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.
Kadam KS; Jadhav RD; Kandre S; Guha T; Reddy MM; Brahma MK; Deshmukh NJ; Dixit A; Doshi L; Srinivasan S; Devle J; Damre A; Nemmani KV; Gupte A; Sharma R
Eur J Med Chem; 2013 Jul; 65():337-47. PubMed ID: 23735282
[TBL] [Abstract][Full Text] [Related]
7. Identification of 2-aminooxazole amides as acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy.
Kim HM; Smith MD; Kim JH; Caplen MA; Chan TY; McKittrick BA; Cook JA; van Heek M; Lachowicz J
Bioorg Med Chem Lett; 2013 Dec; 23(23):6410-4. PubMed ID: 24120540
[TBL] [Abstract][Full Text] [Related]
8. Novel acyl coenzyme A (CoA): diacylglycerol acyltransferase-1 inhibitors: synthesis and biological activities of diacylethylenediamine derivatives.
Nakada Y; Aicher TD; Le Huerou Y; Turner T; Pratt SA; Gonzales SS; Boyd SA; Miki H; Yamamoto T; Yamaguchi H; Kato K; Kitamura S
Bioorg Med Chem; 2010 Apr; 18(7):2785-95. PubMed ID: 20207151
[TBL] [Abstract][Full Text] [Related]
9. Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes.
Pagire SH; Pagire HS; Lee GB; Han SJ; Kwak HJ; Kim JY; Kim KY; Rhee SD; Ryu JI; Song JS; Bae MA; Park MJ; Kim D; Lee DH; Ahn JH
Eur J Med Chem; 2015 Aug; 101():716-35. PubMed ID: 26218650
[TBL] [Abstract][Full Text] [Related]
10. Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.
Dow RL; Andrews MP; Li JC; Michael Gibbs E; Guzman-Perez A; Laperle JL; Li Q; Mather D; Munchhof MJ; Niosi M; Patel L; Perreault C; Tapley S; Zavadoski WJ
Bioorg Med Chem; 2013 Sep; 21(17):5081-97. PubMed ID: 23871442
[TBL] [Abstract][Full Text] [Related]
11. Triazolo compounds useful as diacylglycerol acyltransferase1 inhibitor - WO2009126624.
Matsuda D; Tomoda H
Expert Opin Ther Pat; 2010 Aug; 20(8):1097-102. PubMed ID: 20509774
[TBL] [Abstract][Full Text] [Related]
12. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core.
Dow RL; Andrews M; Aspnes GE; Balan G; Michael Gibbs E; Guzman-Perez A; Karki K; Laperle JL; Li JC; Litchfield J; Munchhof MJ; Perreault C; Patel L
Bioorg Med Chem Lett; 2011 Oct; 21(20):6122-5. PubMed ID: 21908190
[TBL] [Abstract][Full Text] [Related]
13. Discovery of pyrrolopyridazines as novel DGAT1 inhibitors.
Fox BM; Iio K; Li K; Choi R; Inaba T; Jackson S; Sagawa S; Shan B; Tanaka M; Yoshida A; Kayser F
Bioorg Med Chem Lett; 2010 Oct; 20(20):6030-3. PubMed ID: 20833038
[TBL] [Abstract][Full Text] [Related]
14. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.
McCoull W; Addie MS; Birch AM; Birtles S; Buckett LK; Butlin RJ; Bowker SS; Boyd S; Chapman S; Davies RD; Donald CS; Green CP; Jenner C; Kemmitt PD; Leach AG; Moody GC; Gutierrez PM; Newcombe NJ; Nowak T; Packer MJ; Plowright AT; Revill J; Schofield P; Sheldon C; Stokes S; Turnbull AV; Wang SJ; Whalley DP; Wood JM
Bioorg Med Chem Lett; 2012 Jun; 22(12):3873-8. PubMed ID: 22608962
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors.
Mougenot P; Namane C; Fett E; Goumy F; Dadji-Faïhun R; Langot G; Monseau C; Onofri B; Pacquet F; Pascal C; Crespin O; Ben-Hassine M; Ragot JL; Van-Pham T; Philippo C; Chatelain-Egger F; Péron P; Le Bail JC; Guillot E; Chamiot-Clerc P; Chabanaud MA; Pruniaux MP; Ménegotto J; Schmidt F; Venier O; Viviani F; Nicolai E
Bioorg Med Chem Lett; 2016 Jan; 26(1):25-32. PubMed ID: 26627579
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors.
Hong DJ; Jung SH; Kim J; Jung D; Ahn YG; Suh KH; Min KH
J Enzyme Inhib Med Chem; 2020 Dec; 35(1):227-234. PubMed ID: 31752563
[TBL] [Abstract][Full Text] [Related]
17. Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1.
Mougenot P; Namane C; Fett E; Camy F; Dadji-Faïhun R; Langot G; Monseau C; Onofri B; Pacquet F; Pascal C; Crespin O; Ben-Hassine M; Ragot JL; Van-Pham T; Philippo C; Chatelain-Egger F; Péron P; Le Bail JC; Guillot E; Chamiot-Clerc P; Chabanaud MA; Pruniaux MP; Schmidt F; Venier O; Nicolaï E; Viviani F
Bioorg Med Chem Lett; 2012 Apr; 22(7):2497-502. PubMed ID: 22405833
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum.
Lee SW; Rho MC; Park HR; Choi JH; Kang JY; Lee JW; Kim K; Lee HS; Kim YK
J Agric Food Chem; 2006 Dec; 54(26):9759-63. PubMed ID: 17177498
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability.
Bali U; Barba O; Dawson G; Gattrell WT; Horswill JG; Pan DA; Procter MJ; Rasamison CM; Sambrook Smith CP; Taylor-Warne A; Wong-Kai-In P
Bioorg Med Chem Lett; 2012 Jan; 22(2):824-8. PubMed ID: 22217874
[TBL] [Abstract][Full Text] [Related]
20. Discovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors.
Lee K; Kim M; Lee B; Goo J; Kim J; Naik R; Seo JH; Kim MO; Byun Y; Song GY; Lee HS; Choi Y
Org Biomol Chem; 2013 Feb; 11(5):849-58. PubMed ID: 23242135
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
