BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

236 related articles for article (PubMed ID: 23321674)

  • 21. Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.
    Gulati N; Karsy M; Albert L; Murali R; Jhanwar-Uniyal M
    Int J Oncol; 2009 Oct; 35(4):731-40. PubMed ID: 19724909
    [TBL] [Abstract][Full Text] [Related]  

  • 22. A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.
    Liu P; Ge M; Hu J; Li X; Che L; Sun K; Cheng L; Huang Y; Pilo MG; Cigliano A; Pes GM; Pascale RM; Brozzetti S; Vidili G; Porcu A; Cossu A; Palmieri G; Sini MC; Ribback S; Dombrowski F; Tao J; Calvisi DF; Chen L; Chen X
    Hepatology; 2017 Jul; 66(1):167-181. PubMed ID: 28370287
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.
    Bhagwat SV; Gokhale PC; Crew AP; Cooke A; Yao Y; Mantis C; Kahler J; Workman J; Bittner M; Dudkin L; Epstein DM; Gibson NW; Wild R; Arnold LD; Houghton PJ; Pachter JA
    Mol Cancer Ther; 2011 Aug; 10(8):1394-406. PubMed ID: 21673091
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.
    Tamburini J; Chapuis N; Bardet V; Park S; Sujobert P; Willems L; Ifrah N; Dreyfus F; Mayeux P; Lacombe C; Bouscary D
    Blood; 2008 Jan; 111(1):379-82. PubMed ID: 17878402
    [TBL] [Abstract][Full Text] [Related]  

  • 25. CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling.
    Palazuelos J; Ortega Z; Díaz-Alonso J; Guzmán M; Galve-Roperh I
    J Biol Chem; 2012 Jan; 287(2):1198-209. PubMed ID: 22102284
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells.
    Marzec M; Liu X; Wysocka M; Rook AH; Odum N; Wasik MA
    PLoS One; 2011; 6(9):e24849. PubMed ID: 21949767
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice.
    Ruwanpura SM; McLeod L; Miller A; Jones J; Vlahos R; Ramm G; Longano A; Bardin PG; Bozinovski S; Anderson GP; Jenkins BJ
    Am J Physiol Lung Cell Mol Physiol; 2012 Apr; 302(7):L627-39. PubMed ID: 22268122
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids.
    Li H; Lee J; He C; Zou MH; Xie Z
    Am J Physiol Endocrinol Metab; 2014 Jan; 306(2):E197-209. PubMed ID: 24302004
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.
    Zhu YP; Brown JR; Sag D; Zhang L; Suttles J
    J Immunol; 2015 Jan; 194(2):584-94. PubMed ID: 25512602
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Luteinizing hormone/human chorionic gonadotropin-mediated activation of mTORC1 signaling is required for androgen synthesis by theca-interstitial cells.
    Palaniappan M; Menon KM
    Mol Endocrinol; 2012 Oct; 26(10):1732-42. PubMed ID: 22827930
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development.
    Hill DG; Yu L; Gao H; Balic JJ; West A; Oshima H; McLeod L; Oshima M; Gallimore A; D'Costa K; Bhathal PS; Sievert W; Ferrero RL; Jenkins BJ; Jones GW
    Int J Cancer; 2018 Jul; 143(1):167-178. PubMed ID: 29417587
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.
    Gao SP; Mark KG; Leslie K; Pao W; Motoi N; Gerald WL; Travis WD; Bornmann W; Veach D; Clarkson B; Bromberg JF
    J Clin Invest; 2007 Dec; 117(12):3846-56. PubMed ID: 18060032
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence.
    Wall M; Poortinga G; Stanley KL; Lindemann RK; Bots M; Chan CJ; Bywater MJ; Kinross KM; Astle MV; Waldeck K; Hannan KM; Shortt J; Smyth MJ; Lowe SW; Hannan RD; Pearson RB; Johnstone RW; McArthur GA
    Cancer Discov; 2013 Jan; 3(1):82-95. PubMed ID: 23242809
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
    Feldman ME; Apsel B; Uotila A; Loewith R; Knight ZA; Ruggero D; Shokat KM
    PLoS Biol; 2009 Feb; 7(2):e38. PubMed ID: 19209957
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells.
    Shi Y; Zhou W; Cheng L; Chen C; Huang Z; Fang X; Wu Q; He Z; Xu S; Lathia JD; Ping Y; Rich JN; Bian XW; Bao S
    Cell Death Differ; 2017 Jan; 24(1):167-180. PubMed ID: 27740621
    [TBL] [Abstract][Full Text] [Related]  

  • 36. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state.
    Nishihara M; Ogura H; Ueda N; Tsuruoka M; Kitabayashi C; Tsuji F; Aono H; Ishihara K; Huseby E; Betz UA; Murakami M; Hirano T
    Int Immunol; 2007 Jun; 19(6):695-702. PubMed ID: 17493959
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
    Menon S; Yecies JL; Zhang HH; Howell JJ; Nicholatos J; Harputlugil E; Bronson RT; Kwiatkowski DJ; Manning BD
    Sci Signal; 2012 Mar; 5(217):ra24. PubMed ID: 22457330
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Epithelial gp130/Stat3 functions: an intestinal signaling node in health and disease.
    Ernst M; Thiem S; Nguyen PM; Eissmann M; Putoczki TL
    Semin Immunol; 2014 Feb; 26(1):29-37. PubMed ID: 24434062
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia.
    Gao Y; Gao J; Li M; Zheng Y; Wang Y; Zhang H; Wang W; Chu Y; Wang X; Xu M; Cheng T; Ju Z; Yuan W
    J Hematol Oncol; 2016 Apr; 9():36. PubMed ID: 27071307
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells.
    Lee IO; Kim JH; Choi YJ; Pillinger MH; Kim SY; Blaser MJ; Lee YC
    J Biol Chem; 2010 May; 285(21):16042-50. PubMed ID: 20348091
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 12.