These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

76 related articles for article (PubMed ID: 23330538)

  • 1. Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.
    Sinz MW
    Drug Metab Rev; 2013 Feb; 45(1):3-14. PubMed ID: 23330538
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Utility of DPX2 cells for predicting CYP3A induction-mediated drug-drug interactions and associated structure-activity relationships.
    Fahmi OA; Raucy JL; Ponce E; Hassanali S; Lasker JM
    Drug Metab Dispos; 2012 Nov; 40(11):2204-11. PubMed ID: 22912432
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver.
    Hasegawa M; Tahara H; Inoue R; Kakuni M; Tateno C; Ushiki J
    Drug Metab Dispos; 2012 Mar; 40(3):474-80. PubMed ID: 22126990
    [TBL] [Abstract][Full Text] [Related]  

  • 4. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells.
    Tan H; Xu C; Zeng H; Wang Y; Li Y; Fan X; Chen P; Jiang Y; Chen X; Huang M; Bi H
    J Pharmacol Sci; 2016 Feb; 130(2):66-71. PubMed ID: 26782648
    [TBL] [Abstract][Full Text] [Related]  

  • 5. High-throughput evaluation method for drug association with pregnane X receptor (PXR) using differential scanning fluorometry.
    Sekiguchi M; Kobashigawa Y; Moriguchi H; Kawasaki M; Yuda M; Teramura T; Inagaki F
    J Biomol Screen; 2013 Oct; 18(9):1084-91. PubMed ID: 23749765
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss).
    Wassmur B; Gräns J; Kling P; Celander MC
    Aquat Toxicol; 2010 Oct; 100(1):91-100. PubMed ID: 20719396
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Drug-drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibition.
    Dvorak Z
    Toxicol Lett; 2011 Apr; 202(2):129-32. PubMed ID: 21333771
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.
    Vrzal R; Kubesova K; Pavek P; Dvorak Z
    Toxicol Lett; 2010 Mar; 193(2):183-8. PubMed ID: 20080160
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Milk thistle's active components silybin and isosilybin: novel inhibitors of PXR-mediated CYP3A4 induction.
    Mooiman KD; Maas-Bakker RF; Moret EE; Beijnen JH; Schellens JH; Meijerman I
    Drug Metab Dispos; 2013 Aug; 41(8):1494-504. PubMed ID: 23674609
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of clinically used drugs that activate pregnane X receptors.
    Shukla SJ; Sakamuru S; Huang R; Moeller TA; Shinn P; Vanleer D; Auld DS; Austin CP; Xia M
    Drug Metab Dispos; 2011 Jan; 39(1):151-9. PubMed ID: 20966043
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Chronic ethanol exposure downregulates hepatic expression of pregnane X receptor and P450 3A11 in female ICR mice.
    Wang JP; Xu DX; Sun MF; Chen YH; Wang H; Wei W
    Toxicology; 2005 Nov; 215(3):234-44. PubMed ID: 16126318
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The alternatively spliced murine pregnane X receptor isoform, mPXR(delta171-211) exhibits a repressive action.
    Matic M; Corradin AP; Tsoli M; Clarke SJ; Polly P; Robertson GR
    Int J Biochem Cell Biol; 2010 May; 42(5):672-82. PubMed ID: 20060928
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation.
    Zhang H; LeCulyse E; Liu L; Hu M; Matoney L; Zhu W; Yan B
    Arch Biochem Biophys; 1999 Aug; 368(1):14-22. PubMed ID: 10415106
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A nonradioactive electrophoretic mobility shift assay for measurement of pregnane X receptor binding activity to CYP3A4 response element.
    Vavrova A; Vrzal R; Dvorak Z
    Electrophoresis; 2013 Jul; 34(13):1863-8. PubMed ID: 23977680
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Lipopolysaccharide and cecal ligation/puncture differentially affect the subcellular distribution of the pregnane X receptor but consistently cause suppression of its target genes CYP3A.
    Sachdeva K; Yan B; Chichester CO
    Shock; 2003 May; 19(5):469-74. PubMed ID: 12744492
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Diethylstilbestrol-scaffold-based pregnane X receptor modulators.
    Hodnik Ž; Tomašič T; Smodiš D; D'Amore C; Mašič LP; Fiorucci S; Kikelj D
    Eur J Med Chem; 2015 Oct; 103():551-62. PubMed ID: 26408814
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions.
    Ly JQ; Messick K; Qin A; Takahashi RH; Choo EF
    Mol Pharm; 2017 May; 14(5):1754-1759. PubMed ID: 28345929
    [TBL] [Abstract][Full Text] [Related]  

  • 18. PXR mediated induction of CYP3A4, CYP1A2, and P-gp by Mitragyna speciosa and its alkaloids.
    Manda VK; Avula B; Dale OR; Ali Z; Khan IA; Walker LA; Khan SI
    Phytother Res; 2017 Dec; 31(12):1935-1945. PubMed ID: 29071751
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules.
    Negi S; Singh SK; Kumar S; Kumar S; Tyagi RK
    Toxicol In Vitro; 2018 Oct; 52():222-234. PubMed ID: 29933105
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nuclear receptor PXR: discovery of a pharmaceutical anti-target.
    Kliewer SA
    J Clin Invest; 2015 Apr; 125(4):1388-9. PubMed ID: 25831443
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.