249 related articles for article (PubMed ID: 23344974)
1. Using a fragment-based approach to target protein-protein interactions.
Scott DE; Ehebauer MT; Pukala T; Marsh M; Blundell TL; Venkitaraman AR; Abell C; Hyvönen M
Chembiochem; 2013 Feb; 14(3):332-42. PubMed ID: 23344974
[TBL] [Abstract][Full Text] [Related]
2. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases.
Scott DE; Coyne AG; Venkitaraman A; Blundell TL; Abell C; Hyvönen M
ChemMedChem; 2015 Feb; 10(2):296-303. PubMed ID: 25470112
[TBL] [Abstract][Full Text] [Related]
3. Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
Moschetti T; Sharpe T; Fischer G; Marsh ME; Ng HK; Morgan M; Scott DE; Blundell TL; R Venkitaraman A; Skidmore J; Abell C; Hyvönen M
J Mol Biol; 2016 Nov; 428(23):4589-4607. PubMed ID: 27725183
[TBL] [Abstract][Full Text] [Related]
4. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Scott DE; Francis-Newton NJ; Marsh ME; Coyne AG; Fischer G; Moschetti T; Bayly AR; Sharpe TD; Haas KT; Barber L; Valenzano CR; Srinivasan R; Huggins DJ; Lee M; Emery A; Hardwick B; Ehebauer M; Dagostin C; Esposito A; Pellegrini L; Perrior T; McKenzie G; Blundell TL; Hyvönen M; Skidmore J; Venkitaraman AR; Abell C
Cell Chem Biol; 2021 Jun; 28(6):835-847.e5. PubMed ID: 33662256
[TBL] [Abstract][Full Text] [Related]
5. Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
Shin DS; Pellegrini L; Daniels DS; Yelent B; Craig L; Bates D; Yu DS; Shivji MK; Hitomi C; Arvai AS; Volkmann N; Tsuruta H; Blundell TL; Venkitaraman AR; Tainer JA
EMBO J; 2003 Sep; 22(17):4566-76. PubMed ID: 12941707
[TBL] [Abstract][Full Text] [Related]
6. Structure-activity relationship of the peptide binding-motif mediating the BRCA2:RAD51 protein-protein interaction.
Scott DE; Marsh M; Blundell TL; Abell C; Hyvönen M
FEBS Lett; 2016 Apr; 590(8):1094-102. PubMed ID: 26992456
[TBL] [Abstract][Full Text] [Related]
7. Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Pellegrini L; Yu DS; Lo T; Anand S; Lee M; Blundell TL; Venkitaraman AR
Nature; 2002 Nov; 420(6913):287-93. PubMed ID: 12442171
[TBL] [Abstract][Full Text] [Related]
8. Three new structures of left-handed RADA helical filaments: structural flexibility of N-terminal domain is critical for recombinase activity.
Chang YW; Ko TP; Lee CD; Chang YC; Lin KA; Chang CS; Wang AH; Wang TF
PLoS One; 2009; 4(3):e4890. PubMed ID: 19295907
[TBL] [Abstract][Full Text] [Related]
9. New insights into the biological function of BRCA2 from its structural interactions.
Waterworth A
Breast Cancer Res; 2003; 5(2):107-8. PubMed ID: 12631390
[No Abstract] [Full Text] [Related]
10. Interaction between Arabidopsis Brca2 and its partners Rad51, Dmc1, and Dss1.
Dray E; Siaud N; Dubois E; Doutriaux MP
Plant Physiol; 2006 Mar; 140(3):1059-69. PubMed ID: 16415210
[TBL] [Abstract][Full Text] [Related]
11. A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.
Islam MN; Paquet N; Fox D; Dray E; Zheng XF; Klein H; Sung P; Wang W
J Biol Chem; 2012 Jul; 287(28):23808-18. PubMed ID: 22645136
[TBL] [Abstract][Full Text] [Related]
12. Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
Park JY; Singh TR; Nassar N; Zhang F; Freund M; Hanenberg H; Meetei AR; Andreassen PR
Oncogene; 2014 Oct; 33(40):4803-12. PubMed ID: 24141787
[TBL] [Abstract][Full Text] [Related]
13. Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.
Rajendra E; Venkitaraman AR
Nucleic Acids Res; 2010 Jan; 38(1):82-96. PubMed ID: 19875419
[TBL] [Abstract][Full Text] [Related]
14. RecA family proteins in archaea: RadA and its cousins.
Haldenby S; White MF; Allers T
Biochem Soc Trans; 2009 Feb; 37(Pt 1):102-7. PubMed ID: 19143611
[TBL] [Abstract][Full Text] [Related]
15. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.
Silvestre HL; Blundell TL; Abell C; Ciulli A
Proc Natl Acad Sci U S A; 2013 Aug; 110(32):12984-9. PubMed ID: 23872845
[TBL] [Abstract][Full Text] [Related]
16. Molecular mimicry connects BRCA2 to Rad51 and recombinational DNA repair.
Kowalczykowski SC
Nat Struct Biol; 2002 Dec; 9(12):897-9. PubMed ID: 12447354
[No Abstract] [Full Text] [Related]
17. Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity.
Cole DJ; Rajendra E; Roberts-Thomson M; Hardwick B; McKenzie GJ; Payne MC; Venkitaraman AR; Skylaris CK
PLoS Comput Biol; 2011 Jul; 7(7):e1002096. PubMed ID: 21789034
[TBL] [Abstract][Full Text] [Related]
18. Divergent binding mode for a protozoan BRC repeat to RAD51.
Pantelejevs T; Hyvönen M
Biochem J; 2022 May; 479(10):1031-1043. PubMed ID: 35502837
[TBL] [Abstract][Full Text] [Related]
19. The Rad51/RadA N-terminal domain activates nucleoprotein filament ATPase activity.
Galkin VE; Wu Y; Zhang XP; Qian X; He Y; Yu X; Heyer WD; Luo Y; Egelman EH
Structure; 2006 Jun; 14(6):983-92. PubMed ID: 16765891
[TBL] [Abstract][Full Text] [Related]
20. BRCA2 regulates DMC1-mediated recombination through the BRC repeats.
Martinez JS; von Nicolai C; Kim T; Ehlén Å; Mazin AV; Kowalczykowski SC; Carreira A
Proc Natl Acad Sci U S A; 2016 Mar; 113(13):3515-20. PubMed ID: 26976601
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
