BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

419 related articles for article (PubMed ID: 23351063)

  • 1. The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3S-hydroxy-acyl-CoA.
    Kasaragod P; Schmitz W; Hiltunen JK; Wierenga RK
    FEBS J; 2013 Jul; 280(13):3160-75. PubMed ID: 23351063
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis.
    Qin YM; Haapalainen AM; Conry D; Cuebas DA; Hiltunen JK; Novikov DK
    Biochem J; 1997 Dec; 328 ( Pt 2)(Pt 2):377-82. PubMed ID: 9371691
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Amino acid sequence similarities of the mitochondrial short chain delta 3, delta 2-enoyl-CoA isomerase and peroxisomal multifunctional delta 3, delta 2-enoyl-CoA isomerase, 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase enzyme in rat liver. The proposed occurrence of isomerization and hydration in the same catalytic domain of the multifunctional enzyme.
    Palosaari PM; Vihinen M; Mäntsälä PI; Alexson SE; Pihlajaniemi T; Hiltunen JK
    J Biol Chem; 1991 Jun; 266(17):10750-3. PubMed ID: 2040594
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Interchange of catalytic activity within the 2-enoyl-coenzyme A hydratase/isomerase superfamily based on a common active site template.
    Xiang H; Luo L; Taylor KL; Dunaway-Mariano D
    Biochemistry; 1999 Jun; 38(24):7638-52. PubMed ID: 10387003
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Organization of the multifunctional enzyme type 1: interaction between N- and C-terminal domains is required for the hydratase-1/isomerase activity.
    Kiema TR; Taskinen JP; Pirilä PL; Koivuranta KT; Wierenga RK; Hiltunen JK
    Biochem J; 2002 Oct; 367(Pt 2):433-41. PubMed ID: 12106015
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Glutamate 139 of the large alpha-subunit is the catalytic base in the dehydration of both D- and L-3-hydroxyacyl-coenzyme A but not in the isomerization of delta 3, delta 2-enoyl-coenzyme A catalyzed by the multienzyme complex of fatty acid oxidation from Escherichia coli.
    Yang SY; He XY; Schulz H
    Biochemistry; 1995 May; 34(19):6441-7. PubMed ID: 7756275
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Peroxisomal bifunctional protein from rat liver is a trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities.
    Palosaari PM; Hiltunen JK
    J Biol Chem; 1990 Feb; 265(5):2446-9. PubMed ID: 2303409
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Histidine-450 is the catalytic residue of L-3-hydroxyacyl coenzyme A dehydrogenase associated with the large alpha-subunit of the multienzyme complex of fatty acid oxidation from Escherichia coli.
    He XY; Yang SY
    Biochemistry; 1996 Jul; 35(29):9625-30. PubMed ID: 8755745
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular cloning of the cDNAs for the subunits of rat mitochondrial fatty acid beta-oxidation multienzyme complex. Structural and functional relationships to other mitochondrial and peroxisomal beta-oxidation enzymes.
    Kamijo T; Aoyama T; Miyazaki J; Hashimoto T
    J Biol Chem; 1993 Dec; 268(35):26452-60. PubMed ID: 8253773
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evidence for a peroxisomal fatty acid beta-oxidation involving D-3-hydroxyacyl-CoAs. Characterization of two forms of hydro-lyase that convert D-(-)-3-hydroxyacyl-CoA into 2-trans-enoyl-CoA.
    Engeland K; Kindl H
    Eur J Biochem; 1991 Aug; 200(1):171-8. PubMed ID: 1879422
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Peroxisomal Delta3-cis-Delta2-trans-enoyl-CoA isomerase encoded by ECI1 is required for growth of the yeast Saccharomyces cerevisiae on unsaturated fatty acids.
    Gurvitz A; Mursula AM; Firzinger A; Hamilton B; Kilpeläinen SH; Hartig A; Ruis H; Hiltunen JK; Rottensteiner H
    J Biol Chem; 1998 Nov; 273(47):31366-74. PubMed ID: 9813046
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Domains of the tetrafunctional protein acting in glyoxysomal fatty acid beta-oxidation. Demonstration of epimerase and isomerase activities on a peptide lacking hydratase activity.
    Preisig-Müller R; Gühnemann-Schäfer K; Kindl H
    J Biol Chem; 1994 Aug; 269(32):20475-81. PubMed ID: 8051146
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structures of yeast peroxisomal Δ(3),Δ(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole.
    Onwukwe GU; Koski MK; Pihko P; Schmitz W; Wierenga RK
    Acta Crystallogr D Biol Crystallogr; 2015 Nov; 71(Pt 11):2178-91. PubMed ID: 26527136
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Human Δ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.
    Onwukwe GU; Kursula P; Koski MK; Schmitz W; Wierenga RK
    FEBS J; 2015 Feb; 282(4):746-68. PubMed ID: 25515061
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3-ketodecanoyl-CoA: capturing active and inactive states of its hydratase and dehydrogenase catalytic sites.
    Sridhar S; Schmitz W; Hiltunen JK; Venkatesan R; Bergmann U; Kiema TR; Wierenga RK
    Acta Crystallogr D Struct Biol; 2020 Dec; 76(Pt 12):1256-1269. PubMed ID: 33263331
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystallization and characterization of the dehydrogenase domain from rat peroxisomal multifunctional enzyme type 1.
    Taskinen JP; Kiema TR; Koivuranta KT; Wierenga RK; Hiltunen JK
    Acta Crystallogr D Biol Crystallogr; 2002 Apr; 58(Pt 4):690-3. PubMed ID: 11914498
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Enoyl-CoA hydratase and isomerase form a superfamily with a common active-site glutamate residue.
    Müller-Newen G; Janssen U; Stoffel W
    Eur J Biochem; 1995 Feb; 228(1):68-73. PubMed ID: 7883013
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex.
    Ishikawa M; Tsuchiya D; Oyama T; Tsunaka Y; Morikawa K
    EMBO J; 2004 Jul; 23(14):2745-54. PubMed ID: 15229654
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evidence for domain structures of the trifunctional protein and the tetrafunctional protein acting in glyoxysomal fatty acid beta-oxidation.
    Gühnemann-Schäfer K; Engeland K; Linder D; Kindl H
    Eur J Biochem; 1994 Dec; 226(3):909-15. PubMed ID: 7813482
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural enzymology studies with the substrate 3S-hydroxybutanoyl-CoA: bifunctional MFE1 is a less efficient dehydrogenase than monofunctional HAD.
    Sridhar S; Kiema TR; Schmitz W; Widersten M; Wierenga RK
    FEBS Open Bio; 2024 Apr; 14(4):655-674. PubMed ID: 38458818
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.