236 related articles for article (PubMed ID: 23382194)
1. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.
Shang X; Marchioni F; Evelyn CR; Sipes N; Zhou X; Seibel W; Wortman M; Zheng Y
Proc Natl Acad Sci U S A; 2013 Feb; 110(8):3155-60. PubMed ID: 23382194
[TBL] [Abstract][Full Text] [Related]
2. Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).
Jaiswal M; Gremer L; Dvorsky R; Haeusler LC; Cirstea IC; Uhlenbrock K; Ahmadian MR
J Biol Chem; 2011 May; 286(20):18202-12. PubMed ID: 21454492
[TBL] [Abstract][Full Text] [Related]
3. Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA.
Reuther GW; Lambert QT; Booden MA; Wennerberg K; Becknell B; Marcucci G; Sondek J; Caligiuri MA; Der CJ
J Biol Chem; 2001 Jul; 276(29):27145-51. PubMed ID: 11373293
[TBL] [Abstract][Full Text] [Related]
4. High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay.
Evelyn CR; Ferng T; Rojas RJ; Larsen MJ; Sondek J; Neubig RR
J Biomol Screen; 2009 Feb; 14(2):161-72. PubMed ID: 19196702
[TBL] [Abstract][Full Text] [Related]
5. Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
Kristelly R; Gao G; Tesmer JJ
J Biol Chem; 2004 Nov; 279(45):47352-62. PubMed ID: 15331592
[TBL] [Abstract][Full Text] [Related]
6. Small chemical compounds Y16 and Rhosin can inhibit calcium sensitization pathway in vascular smooth muscle cells of spontaneously hypertensive rats.
Chiu WC; Chiang JY; Chiang FT
J Formos Med Assoc; 2021 Oct; 120(10):1863-1868. PubMed ID: 33893012
[TBL] [Abstract][Full Text] [Related]
7. Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.
Booden MA; Siderovski DP; Der CJ
Mol Cell Biol; 2002 Jun; 22(12):4053-61. PubMed ID: 12024019
[TBL] [Abstract][Full Text] [Related]
8. Rho-specific Guanine nucleotide exchange factors (Rho-GEFs) inhibition affects macrophage phenotype and disrupts Golgi complex.
Chen W; Zhao Y; Li XC; Kubiak JZ; Ghobrial RM; Kloc M
Int J Biochem Cell Biol; 2017 Dec; 93():12-24. PubMed ID: 29061365
[TBL] [Abstract][Full Text] [Related]
9. Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation.
Zhu K; Debreceni B; Li R; Zheng Y
J Biol Chem; 2000 Aug; 275(34):25993-6001. PubMed ID: 10854437
[TBL] [Abstract][Full Text] [Related]
10. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG.
Aurandt J; Vikis HG; Gutkind JS; Ahn N; Guan KL
Proc Natl Acad Sci U S A; 2002 Sep; 99(19):12085-90. PubMed ID: 12196628
[TBL] [Abstract][Full Text] [Related]
11. A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.
Aittaleb M; Gao G; Evelyn CR; Neubig RR; Tesmer JJ
Cell Signal; 2009 Nov; 21(11):1569-78. PubMed ID: 19560536
[TBL] [Abstract][Full Text] [Related]
12. On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.
Zheng M; Cierpicki T; Momotani K; Artamonov MV; Derewenda U; Bushweller JH; Somlyo AV; Derewenda ZS
BMC Struct Biol; 2009 May; 9():36. PubMed ID: 19460155
[TBL] [Abstract][Full Text] [Related]
13. Rational design of Rho GTPase-targeting inhibitors.
Shang X; Zheng Y
Methods Mol Biol; 2012; 928():29-38. PubMed ID: 22956131
[TBL] [Abstract][Full Text] [Related]
14. Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.
Debreceni B; Gao Y; Guo F; Zhu K; Jia B; Zheng Y
J Biol Chem; 2004 Jan; 279(5):3777-86. PubMed ID: 14597635
[TBL] [Abstract][Full Text] [Related]
15. The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF.
Oleksy A; Opaliński Ł; Derewenda U; Derewenda ZS; Otlewski J
J Biol Chem; 2006 Oct; 281(43):32891-7. PubMed ID: 16954208
[TBL] [Abstract][Full Text] [Related]
16. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
Arthur WT; Ellerbroek SM; Der CJ; Burridge K; Wennerberg K
J Biol Chem; 2002 Nov; 277(45):42964-72. PubMed ID: 12221096
[TBL] [Abstract][Full Text] [Related]
17. Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors.
Li R; Zheng Y
J Biol Chem; 1997 Feb; 272(8):4671-9. PubMed ID: 9030518
[TBL] [Abstract][Full Text] [Related]
18. Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.
Gasmi-Seabrook GM; Marshall CB; Cheung M; Kim B; Wang F; Jang YJ; Mak TW; Stambolic V; Ikura M
J Biol Chem; 2010 Feb; 285(8):5137-45. PubMed ID: 20018869
[TBL] [Abstract][Full Text] [Related]
19. The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling.
Boissier P; Huynh-Do U
Cell Signal; 2014 Mar; 26(3):483-91. PubMed ID: 24308970
[TBL] [Abstract][Full Text] [Related]
20. Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor.
Blomquist A; Schwörer G; Schablowski H; Psoma A; Lehnen M; Jakobs KH; Rümenapp U
Biochem J; 2000 Dec; 352 Pt 2(Pt 2):319-25. PubMed ID: 11085924
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]