BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

269 related articles for article (PubMed ID: 23434029)

  • 1. Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators.
    Chae E; Shin YJ; Ryu EJ; Ji MK; Ryune Cho N; Lee KH; Jeong HJ; Kim SJ; Choi Y; Seok Oh K; Park CE; Soo Yoon Y
    Bioorg Med Chem Lett; 2013 Apr; 23(7):2134-9. PubMed ID: 23434029
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.
    Anighoro A; Graziani D; Bettinelli I; Cilia A; De Toma C; Longhi M; Mangiarotti F; Menegon S; Pirona L; Poggesi E; Riva C; Rastelli G
    Bioorg Med Chem; 2015 Jul; 23(13):3040-58. PubMed ID: 26014480
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.
    Weiss JM; Jimenez HN; Li G; April M; Uberti MA; Bacolod MD; Brodbeck RM; Doller D
    Bioorg Med Chem Lett; 2011 Aug; 21(16):4891-9. PubMed ID: 21757343
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs.
    Wágner G; Wéber C; Nyéki O; Nógrádi K; Bielik A; Molnár L; Bobok A; Horváth A; Kiss B; Kolok S; Nagy J; Kurkó D; Gál K; Greiner I; Szombathelyi Z; Keseru GM; Domány G
    Bioorg Med Chem Lett; 2010 Jun; 20(12):3737-41. PubMed ID: 20483612
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators.
    Zhou H; Topiol SW; Grenon M; Jimenez HN; Uberti MA; Smith DG; Brodbeck RM; Chandrasena G; Pedersen H; Madsen JC; Doller D; Li G
    Bioorg Med Chem Lett; 2013 Mar; 23(5):1398-406. PubMed ID: 23357634
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Recent progress in the discovery and development of negative allosteric modulators of mGluR5.
    Lindsley CW; Emmitte KA
    Curr Opin Drug Discov Devel; 2009 Jul; 12(4):446-57. PubMed ID: 19562641
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.
    Xiong H; Brugel TA; Balestra M; Brown DG; Brush KA; Hightower C; Hinkley L; Hoesch V; Kang J; Koether GM; McCauley JP; McLaren FM; Panko LM; Simpson TR; Smith RW; Woods JM; Brockel B; Chhajlani V; Gadient RA; Spear N; Sygowski LA; Zhang M; Arora J; Breysse N; Wilson JM; Isaac M; Slassi A; King MM
    Bioorg Med Chem Lett; 2010 Dec; 20(24):7381-4. PubMed ID: 21067920
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.
    Kulkarni SS; Nightingale B; Dersch CM; Rothman RB; Newman AH
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3371-5. PubMed ID: 16678408
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core.
    Duvey G; Perry B; Le Poul E; Poli S; Bonnet B; Lambeng N; Charvin D; Donovan-Rodrigues T; Haddouk H; Gagliardi S; Rocher JP
    Bioorg Med Chem Lett; 2013 Aug; 23(16):4523-7. PubMed ID: 23850200
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
    Silvestri R; Ligresti A; La Regina G; Piscitelli F; Gatti V; Lavecchia A; Brizzi A; Pasquini S; Allarà M; Fantini N; Carai MA; Bigogno C; Rozio MG; Sinisi R; Novellino E; Colombo G; Di Marzo V; Dondio G; Corelli F
    Eur J Med Chem; 2010 Dec; 45(12):5878-86. PubMed ID: 20943290
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
    Jaeschke G; Kolczewski S; Spooren W; Vieira E; Bitter-Stoll N; Boissin P; Borroni E; Büttelmann B; Ceccarelli S; Clemann N; David B; Funk C; Guba W; Harrison A; Hartung T; Honer M; Huwyler J; Kuratli M; Niederhauser U; Pähler A; Peters JU; Petersen A; Prinssen E; Ricci A; Rueher D; Rueher M; Schneider M; Spurr P; Stoll T; Tännler D; Wichmann J; Porter RH; Wettstein JG; Lindemann L
    J Med Chem; 2015 Feb; 58(3):1358-71. PubMed ID: 25565255
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Efficacy switching SAR of mGluR5 allosteric modulators: highly potent positive and negative modulators from one chemotype.
    Sams AG; Mikkelsen GK; Brodbeck RM; Pu X; Ritzén A
    Bioorg Med Chem Lett; 2011 Jun; 21(11):3407-10. PubMed ID: 21531137
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.
    Packiarajan M; Grenon M; Zorn S; Hopper AT; White AD; Chandrasena G; Pu X; Brodbeck RM; Robichaud AJ
    Bioorg Med Chem Lett; 2013 Jul; 23(14):4037-43. PubMed ID: 23770058
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
    Lindsley CW; Wisnoski DD; Leister WH; O'brien JA; Lemaire W; Williams DL; Burno M; Sur C; Kinney GG; Pettibone DJ; Tiller PR; Smith S; Duggan ME; Hartman GD; Conn PJ; Huff JR
    J Med Chem; 2004 Nov; 47(24):5825-8. PubMed ID: 15537338
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
    Bonnefous C; Vernier JM; Hutchinson JH; Chung J; Reyes-Manalo G; Kamenecka T
    Bioorg Med Chem Lett; 2005 Feb; 15(4):1197-200. PubMed ID: 15686941
    [TBL] [Abstract][Full Text] [Related]  

  • 16. N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.
    Felts AS; Rodriguez AL; Morrison RD; Venable DF; Blobaum AL; Byers FW; Daniels JS; Niswender CM; Jones CK; Conn PJ; Lindsley CW; Emmitte KA
    Bioorg Med Chem Lett; 2016 Apr; 26(8):1894-900. PubMed ID: 26988308
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of imidazole carboxamides as potent and selective CCK1R agonists.
    Zhu C; Hansen AR; Bateman T; Chen Z; Holt TG; Hubert JA; Karanam BV; Lee SJ; Pan J; Qian S; Reddy VB; Reitman ML; Strack AM; Tong V; Weingarth DT; Wolff MS; MacNeil DJ; Weber AE; Duffy JL; Edmondson SD
    Bioorg Med Chem Lett; 2008 Aug; 18(15):4393-6. PubMed ID: 18614364
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.
    Lindemann L; Jaeschke G; Michalon A; Vieira E; Honer M; Spooren W; Porter R; Hartung T; Kolczewski S; Büttelmann B; Flament C; Diener C; Fischer C; Gatti S; Prinssen EP; Parrott N; Hoffmann G; Wettstein JG
    J Pharmacol Exp Ther; 2011 Nov; 339(2):474-86. PubMed ID: 21849627
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.
    Turlington M; Noetzel MJ; Bridges TM; Vinson PN; Steckler T; Lavreysen H; Mackie C; Bartolomé-Nebreda JM; Conde-Ceide S; Tong HM; Macdonald GJ; Daniels JS; Jones CK; Niswender CM; Conn PJ; Lindsley CW; Stauffer SR
    Bioorg Med Chem Lett; 2014 Aug; 24(15):3641-6. PubMed ID: 24961642
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5.
    Arsova A; Møller TC; Vedel L; Hansen JL; Foster SR; Gregory KJ; Bräuner-Osborne H
    Mol Pharmacol; 2020 Jul; 98(1):49-60. PubMed ID: 32358164
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.