145 related articles for article (PubMed ID: 23434414)
1. Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1.
Sifferlen T; Koberstein R; Cottreel E; Boller A; Weller T; Gatfield J; Brisbare-Roch C; Jenck F; Boss C
Bioorg Med Chem Lett; 2013 Apr; 23(7):2212-6. PubMed ID: 23434414
[TBL] [Abstract][Full Text] [Related]
2. Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2.
Sifferlen T; Koberstein R; Cottreel E; Boller A; Weller T; Gatfield J; Brisbare-Roch C; Jenck F; Boss C
Bioorg Med Chem Lett; 2013 Jul; 23(13):3857-63. PubMed ID: 23719231
[TBL] [Abstract][Full Text] [Related]
3. Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists.
Sifferlen T; Boss C; Cottreel E; Koberstein R; Gude M; Aissaoui H; Weller T; Gatfield J; Brisbare-Roch C; Jenck F
Bioorg Med Chem Lett; 2010 Mar; 20(5):1539-42. PubMed ID: 20144866
[TBL] [Abstract][Full Text] [Related]
4. Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.
Dugovic C; Shelton JE; Aluisio LE; Fraser IC; Jiang X; Sutton SW; Bonaventure P; Yun S; Li X; Lord B; Dvorak CA; Carruthers NI; Lovenberg TW
J Pharmacol Exp Ther; 2009 Jul; 330(1):142-51. PubMed ID: 19363060
[TBL] [Abstract][Full Text] [Related]
5. Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists.
Fujimoto T; Tomata Y; Kunitomo J; Hirozane M; Marui S
Bioorg Med Chem Lett; 2011 Nov; 21(21):6409-13. PubMed ID: 21924608
[TBL] [Abstract][Full Text] [Related]
6. Orexin receptor antagonists: medicinal chemistry and therapeutic potential.
Roecker AJ; Coleman PJ
Curr Top Med Chem; 2008; 8(11):977-87. PubMed ID: 18673167
[TBL] [Abstract][Full Text] [Related]
7. Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
Di Fabio R; Pellacani A; Faedo S; Roth A; Piccoli L; Gerrard P; Porter RA; Johnson CN; Thewlis K; Donati D; Stasi L; Spada S; Stemp G; Nash D; Branch C; Kindon L; Massagrande M; Poffe A; Braggio S; Chiarparin E; Marchioro C; Ratti E; Corsi M
Bioorg Med Chem Lett; 2011 Sep; 21(18):5562-7. PubMed ID: 21831639
[TBL] [Abstract][Full Text] [Related]
8. Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists.
Fujimoto T; Kunitomo J; Tomata Y; Nishiyama K; Nakashima M; Hirozane M; Yoshikubo S; Hirai K; Marui S
Bioorg Med Chem Lett; 2011 Nov; 21(21):6414-6. PubMed ID: 21917455
[TBL] [Abstract][Full Text] [Related]
9. Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists.
Stasi LP; Artusi R; Bovino C; Buzzi B; Canciani L; Caselli G; Colace F; Garofalo P; Giambuzzi S; Larger P; Letari O; Mandelli S; Perugini L; Pucci S; Salvi M; Toro P
Bioorg Med Chem Lett; 2013 May; 23(9):2653-8. PubMed ID: 23535328
[TBL] [Abstract][Full Text] [Related]
10. N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists.
Aissaoui H; Koberstein R; Zumbrunn C; Gatfield J; Brisbare-Roch C; Jenck F; Treiber A; Boss C
Bioorg Med Chem Lett; 2008 Nov; 18(21):5729-33. PubMed ID: 18845436
[TBL] [Abstract][Full Text] [Related]
11. Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure.
Winrow CJ; Tanis KQ; Reiss DR; Rigby AM; Uslaner JM; Uebele VN; Doran SM; Fox SV; Garson SL; Gotter AL; Levine DM; Roecker AJ; Coleman PJ; Koblan KS; Renger JJ
Neuropharmacology; 2010 Jan; 58(1):185-94. PubMed ID: 19596018
[TBL] [Abstract][Full Text] [Related]
12. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists.
Malherbe P; Borroni E; Pinard E; Wettstein JG; Knoflach F
Mol Pharmacol; 2009 Sep; 76(3):618-31. PubMed ID: 19542319
[TBL] [Abstract][Full Text] [Related]
13. Proline bis-amides as potent dual orexin receptor antagonists.
Bergman JM; Roecker AJ; Mercer SP; Bednar RA; Reiss DR; Ransom RW; Meacham Harrell C; Pettibone DJ; Lemaire W; Murphy KL; Li C; Prueksaritanont T; Winrow CJ; Renger JJ; Koblan KS; Hartman GD; Coleman PJ
Bioorg Med Chem Lett; 2008 Feb; 18(4):1425-30. PubMed ID: 18207395
[TBL] [Abstract][Full Text] [Related]
14. Structure-Activity Relationship Studies on Oxazolo[3,4-
Albanese V; Ruzza C; Marzola E; Bernardi T; Fabbri M; Fantinati A; Trapella C; Reinscheid RK; Ferrari F; Sturaro C; Calò G; Amendola G; Cosconati S; Pacifico S; Guerrini R; Preti D
J Med Chem; 2021 Apr; 64(7):4089-4108. PubMed ID: 33733768
[TBL] [Abstract][Full Text] [Related]
15. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.
Hirose M; Egashira S; Goto Y; Hashihayata T; Ohtake N; Iwaasa H; Hata M; Fukami T; Kanatani A; Yamada K
Bioorg Med Chem Lett; 2003 Dec; 13(24):4497-9. PubMed ID: 14643355
[TBL] [Abstract][Full Text] [Related]
16. Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1.
Sifferlen T; Boller A; Chardonneau A; Cottreel E; Hoecker J; Aissaoui H; Williams JT; Brotschi C; Heidmann B; Siegrist R; Gatfield J; Treiber A; Brisbare-Roch C; Jenck F; Boss C
Bioorg Med Chem Lett; 2014 Feb; 24(4):1201-8. PubMed ID: 24447850
[TBL] [Abstract][Full Text] [Related]
17. Scaffold hopping, synthesis and structure-activity relationships of 5,6-diaryl-pyrazine-2-amide derivatives: a novel series of CB1 receptor antagonists.
Boström J; Berggren K; Elebring T; Greasley PJ; Wilstermann M
Bioorg Med Chem; 2007 Jun; 15(12):4077-84. PubMed ID: 17433696
[TBL] [Abstract][Full Text] [Related]
18. Treatment and prevention of various therapeutic conditions using OX receptor antagonistic activity (WO2012081692).
Christopher JA; Congreve MS
Expert Opin Ther Pat; 2013 Feb; 23(2):273-7. PubMed ID: 23282091
[TBL] [Abstract][Full Text] [Related]
19. Almorexant, a dual orexin receptor antagonist for the treatment of insomnia.
Neubauer DN
Curr Opin Investig Drugs; 2010 Jan; 11(1):101-10. PubMed ID: 20047164
[TBL] [Abstract][Full Text] [Related]
20. Requirement of intact disulfide bonds in orexin-A-induced stimulation of gastric acid secretion that is mediated by OX1 receptor activation.
Okumura T; Takeuchi S; Motomura W; Yamada H; Egashira Si S; Asahi S; Kanatani A; Ihara M; Kohgo Y
Biochem Biophys Res Commun; 2001 Feb; 280(4):976-81. PubMed ID: 11162621
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]