BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

104 related articles for article (PubMed ID: 23442161)

  • 1. Through the looking glass: adventures in kinase inhibitor design and optimization.
    Clark RD
    J Med Chem; 2013 Mar; 56(5):1796-8. PubMed ID: 23442161
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases.
    Jimenez JM; Boyall D; Brenchley G; Collier PN; Davis CJ; Fraysse D; Keily SB; Henderson J; Miller A; Pierard F; Settimo L; Twin HC; Bolton CM; Curnock AP; Chiu P; Tanner AJ; Young S
    J Med Chem; 2013 Mar; 56(5):1799-810. PubMed ID: 23398373
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
    Cole DC; Asselin M; Brennan A; Czerwinski R; Ellingboe JW; Fitz L; Greco R; Huang X; Joseph-McCarthy D; Kelly MF; Kirisits M; Lee J; Li Y; Morgan P; Stock JR; Tsao DH; Wissner A; Yang X; Chaudhary D
    J Med Chem; 2008 Oct; 51(19):5958-63. PubMed ID: 18783200
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles.
    Shim J; Eid C; Lee J; Liu E; Chaudhary D; Boschelli DH
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6575-7. PubMed ID: 19854645
    [TBL] [Abstract][Full Text] [Related]  

  • 5. First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.
    Niu C; Boschelli DH; Tumey LN; Bhagirath N; Subrath J; Shim J; Wang Y; Wu B; Eid C; Lee J; Yang X; Brennan A; Chaudhary D
    Bioorg Med Chem Lett; 2009 Oct; 19(20):5829-32. PubMed ID: 19762237
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors.
    Katoh T; Tomata Y; Setoh M; Sasaki S; Takai T; Yoshitomi Y; Yukawa T; Nakagawa H; Fukumoto S; Tsukamoto T; Nakada Y
    Bioorg Med Chem Lett; 2017 Jun; 27(11):2497-2501. PubMed ID: 28400232
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 5-Vinyl-3-pyridinecarbonitrile inhibitors of PKCtheta: optimization of enzymatic and functional activity.
    Tumey LN; Bhagirath N; Brennan A; Brooijmans N; Lee J; Yang X; Boschelli DH
    Bioorg Med Chem; 2009 Dec; 17(23):7933-48. PubMed ID: 19884013
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCtheta inhibitors.
    Boschelli DH; Wang D; Prashad AS; Subrath J; Wu B; Niu C; Lee J; Yang X; Brennan A; Chaudhary D
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3623-6. PubMed ID: 19447612
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and PKCtheta inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles.
    Dushin RG; Nittoli T; Ingalls C; Boschelli DH; Cole DC; Wissner A; Lee J; Yang X; Morgan P; Brennan A; Chaudhary D
    Bioorg Med Chem Lett; 2009 May; 19(9):2461-3. PubMed ID: 19345579
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles.
    Boschelli DH; Wu B; Barrios Sosa AC; Chen J; Asselin M; Cole DC; Lee J; Yang X; Chaudhary D
    Bioorg Med Chem Lett; 2008 May; 18(9):2850-3. PubMed ID: 18434148
    [TBL] [Abstract][Full Text] [Related]  

  • 11. C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCtheta inhibitors: part II.
    Prashad AS; Wang D; Subrath J; Wu B; Lin M; Zhang MY; Kagan N; Lee J; Yang X; Brennan A; Chaudhary D; Xu X; Leung L; Wang J; Boschelli DH
    Bioorg Med Chem Lett; 2009 Oct; 19(19):5799-802. PubMed ID: 19703774
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability.
    Kunikawa S; Tanaka A; Mukoyoshi K; Nagashima S; Tominaga H; Chida N; Tasaki M; Shirai F
    Bioorg Med Chem; 2015 Jul; 23(13):3269-77. PubMed ID: 25982074
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based optimization of PKCtheta inhibitors.
    Mosyak L; Xu Z; Joseph-McCarthy D; Brooijmans N; Somers W; Chaudhary D
    Biochem Soc Trans; 2007 Nov; 35(Pt 5):1027-31. PubMed ID: 17956269
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective protein kinase Cθ (PKCθ) inhibitors for the treatment of autoimmune diseases.
    Curnock A; Bolton C; Chiu P; Doyle E; Fraysse D; Hesse M; Jones J; Weber P; Jimenez JM
    Biochem Soc Trans; 2014 Dec; 42(6):1524-8. PubMed ID: 25399564
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta.
    Nathan Tumey L; Boschelli DH; Lee J; Chaudhary D
    Bioorg Med Chem Lett; 2008 Aug; 18(15):4420-3. PubMed ID: 18606543
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Small molecule inhibitors of PKCTheta as potential antiinflammatory therapeutics.
    Boschelli DH
    Curr Top Med Chem; 2009; 9(7):640-54. PubMed ID: 19689371
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Directed modulation of protein kinase C isozyme selectivity with bisubstrate-based inhibitors.
    van Wandelen LT; van Ameijde J; Mady AS; Wammes AE; Bode A; Poot AJ; Ruijtenbeek R; Liskamp RM
    ChemMedChem; 2012 Dec; 7(12):2113-21. PubMed ID: 23139239
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.
    van Eis MJ; Evenou JP; Floersheim P; Gaul C; Cowan-Jacob SW; Monovich L; Rummel G; Schuler W; Stark W; Strauss A; von Matt A; Vangrevelinghe E; Wagner J; Soldermann N
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7367-72. PubMed ID: 22078216
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Development of selective bisubstrate-based inhibitors against protein kinase C (PKC) isozymes by using dynamic peptide microarrays.
    Poot AJ; van Ameijde J; Slijper M; van den Berg A; Hilhorst R; Ruijtenbeek R; Rijkers DT; Liskamp RM
    Chembiochem; 2009 Aug; 10(12):2042-51. PubMed ID: 19618415
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit.
    George DM; Breinlinger EC; Friedman M; Zhang Y; Wang J; Argiriadi M; Bansal-Pakala P; Barth M; Duignan DB; Honore P; Lang Q; Mittelstadt S; Potin D; Rundell L; Edmunds JJ
    J Med Chem; 2015 Jan; 58(1):222-36. PubMed ID: 25000588
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.