150 related articles for article (PubMed ID: 23453072)
1. Design, synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 (aggrecanase-2) inhibitors.
Atobe M; Maekawara N; Kawanishi M; Suzuki H; Tanaka E; Miyoshi S
Bioorg Med Chem Lett; 2013 Apr; 23(7):2111-6. PubMed ID: 23453072
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors.
Shiozaki M; Imai H; Maeda K; Miura T; Yasue K; Suma A; Yokota M; Ogoshi Y; Haas J; Fryer AM; Laird ER; Littmann NM; Andrews SW; Josey JA; Mimura T; Shinozaki Y; Yoshiuchi H; Inaba T
Bioorg Med Chem Lett; 2009 Nov; 19(21):6213-7. PubMed ID: 19767207
[TBL] [Abstract][Full Text] [Related]
3. A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors.
Atobe M; Maekawara N; Ishiguro N; Sogame S; Suenaga Y; Kawanishi M; Suzuki H; Jinno N; Tanaka E; Miyoshi S
Bioorg Med Chem Lett; 2013 Apr; 23(7):2106-10. PubMed ID: 23453070
[TBL] [Abstract][Full Text] [Related]
4. Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.
Govinda Rao B; Bandarage UK; Wang T; Come JH; Perola E; Wei Y; Tian SK; Saunders JO
Bioorg Med Chem Lett; 2007 Apr; 17(8):2250-3. PubMed ID: 17289381
[TBL] [Abstract][Full Text] [Related]
5. Conversion of potent MMP inhibitors into selective TACE inhibitors.
Cherney RJ; King BW; Gilmore JL; Liu RQ; Covington MB; Duan JJ; Decicco CP
Bioorg Med Chem Lett; 2006 Feb; 16(4):1028-31. PubMed ID: 16289878
[TBL] [Abstract][Full Text] [Related]
6. Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors.
Shiozaki M; Maeda K; Miura T; Ogoshi Y; Haas J; Fryer AM; Laird ER; Littmann NM; Andrews SW; Josey JA; Mimura T; Shinozaki Y; Yoshiuchi H; Inaba T
Bioorg Med Chem Lett; 2009 Mar; 19(6):1575-80. PubMed ID: 19243944
[TBL] [Abstract][Full Text] [Related]
7. Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
Nuti E; Santamaria S; Casalini F; Yamamoto K; Marinelli L; La Pietra V; Novellino E; Orlandini E; Nencetti S; Marini AM; Salerno S; Taliani S; Da Settimo F; Nagase H; Rossello A
Eur J Med Chem; 2013 Apr; 62():379-94. PubMed ID: 23376997
[TBL] [Abstract][Full Text] [Related]
8. Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.
Hu Y; Xing L; Thomason JR; Xiang J; Ipek M; Guler S; Li H; Sabatini J; Chockalingam P; Reifenberg E; Sheldon R; Morris EA; Georgiadis KE; Tam S
Bioorg Med Chem Lett; 2011 Nov; 21(22):6800-3. PubMed ID: 21982494
[TBL] [Abstract][Full Text] [Related]
9. Development of novel tetrahydrothieno[2,3-c]pyridine-3-carboxamide based Mycobacterium tuberculosis pantothenate synthetase inhibitors: molecular hybridization from known antimycobacterial leads.
Samala G; Devi PB; Nallangi R; Sridevi JP; Saxena S; Yogeeswari P; Sriram D
Bioorg Med Chem; 2014 Mar; 22(6):1938-47. PubMed ID: 24565972
[TBL] [Abstract][Full Text] [Related]
10. Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
Deng H; O'Keefe H; Davie CP; Lind KE; Acharya RA; Franklin GJ; Larkin J; Matico R; Neeb M; Thompson MM; Lohr T; Gross JW; Centrella PA; O'Donovan GK; Bedard KL; van Vloten K; Mataruse S; Skinner SR; Belyanskaya SL; Carpenter TY; Shearer TW; Clark MA; Cuozzo JW; Arico-Muendel CC; Morgan BA
J Med Chem; 2012 Aug; 55(16):7061-79. PubMed ID: 22891645
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2).
Bursavich MG; Gilbert AM; Lombardi S; Georgiadis KE; Reifenberg E; Flannery CR; Morris EA
Bioorg Med Chem Lett; 2007 Mar; 17(5):1185-8. PubMed ID: 17210251
[TBL] [Abstract][Full Text] [Related]
12. Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group.
Maingot L; Elbakali J; Dumont J; Bosc D; Cousaert N; Urban A; Deglane G; Villoutreix B; Nagase H; Sperandio O; Leroux F; Deprez B; Deprez-Poulain R
Eur J Med Chem; 2013 Nov; 69():244-61. PubMed ID: 24044937
[TBL] [Abstract][Full Text] [Related]
13. Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.
Huang A; Joseph-McCarthy D; Lovering F; Sun L; Wang W; Xu W; Zhu Y; Cui J; Zhang Y; Levin JI
Bioorg Med Chem; 2007 Sep; 15(18):6170-81. PubMed ID: 17606376
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.
Xiang JS; Hu Y; Rush TS; Thomason JR; Ipek M; Sum PE; Abrous L; Sabatini JJ; Georgiadis K; Reifenberg E; Majumdar M; Morris EA; Tam S
Bioorg Med Chem Lett; 2006 Jan; 16(2):311-6. PubMed ID: 16275085
[TBL] [Abstract][Full Text] [Related]
15. Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.
De Savi C; Pape A; Sawyer Y; Milne D; Davies C; Cumming JG; Ting A; Lamont S; Smith PD; Tart J; Page K; Moore P
Bioorg Med Chem Lett; 2011 Jun; 21(11):3301-6. PubMed ID: 21536437
[TBL] [Abstract][Full Text] [Related]
16. N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2).
Gilbert AM; Bursavich MG; Lombardi S; Georgiadis KE; Reifenberg E; Flannery CR; Morris EA
Bioorg Med Chem Lett; 2008 Dec; 18(24):6454-7. PubMed ID: 18974001
[TBL] [Abstract][Full Text] [Related]
17. Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping.
Sogame S; Suenaga Y; Atobe M; Kawanishi M; Tanaka E; Miyoshi S
Eur J Med Chem; 2014 Jan; 71():250-8. PubMed ID: 24316668
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.
Park K; Gopalsamy A; Aplasca A; Ellingboe JW; Xu W; Zhang Y; Levin JI
Bioorg Med Chem; 2009 Jun; 17(11):3857-65. PubMed ID: 19410464
[TBL] [Abstract][Full Text] [Related]
19. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS
J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391
[TBL] [Abstract][Full Text] [Related]
20. Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models.
Nuti E; Casalini F; Santamaria S; Fabbi M; Carbotti G; Ferrini S; Marinelli L; La Pietra V; Novellino E; Camodeca C; Orlandini E; Nencetti S; Rossello A
J Med Chem; 2013 Oct; 56(20):8089-103. PubMed ID: 24044434
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
