329 related articles for article (PubMed ID: 23454517)
21. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Lan JS; Xie SS; Li SY; Pan LF; Wang XB; Kong LY
Bioorg Med Chem; 2014 Nov; 22(21):6089-104. PubMed ID: 25282654
[TBL] [Abstract][Full Text] [Related]
22. Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Bautista-Aguilera OM; Esteban G; Bolea I; Nikolic K; Agbaba D; Moraleda I; Iriepa I; Samadi A; Soriano E; Unzeta M; Marco-Contelles J
Eur J Med Chem; 2014 Mar; 75():82-95. PubMed ID: 24530494
[TBL] [Abstract][Full Text] [Related]
23. Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
Bautista-Aguilera OM; Esteban G; Chioua M; Nikolic K; Agbaba D; Moraleda I; Iriepa I; Soriano E; Samadi A; Unzeta M; Marco-Contelles J
Drug Des Devel Ther; 2014; 8():1893-910. PubMed ID: 25378907
[TBL] [Abstract][Full Text] [Related]
24. Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.
da Costa JS; Lopes JP; Russowsky D; Petzhold CL; Borges AC; Ceschi MA; Konrath E; Batassini C; Lunardi PS; Gonçalves CA
Eur J Med Chem; 2013 Apr; 62():556-63. PubMed ID: 23422935
[TBL] [Abstract][Full Text] [Related]
25. Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site.
Tripathi RKP; M Sasi V; Gupta SK; Krishnamurthy S; Ayyannan SR
J Enzyme Inhib Med Chem; 2018 Dec; 33(1):37-57. PubMed ID: 29098902
[TBL] [Abstract][Full Text] [Related]
26. Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.
Khoobi M; Alipour M; Moradi A; Sakhteman A; Nadri H; Razavi SF; Ghandi M; Foroumadi A; Shafiee A
Eur J Med Chem; 2013 Oct; 68():291-300. PubMed ID: 23988412
[TBL] [Abstract][Full Text] [Related]
27. Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.
Mao F; Chen J; Zhou Q; Luo Z; Huang L; Li X
Bioorg Med Chem Lett; 2013 Dec; 23(24):6737-42. PubMed ID: 24220172
[TBL] [Abstract][Full Text] [Related]
28. O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.
Mao F; Huang L; Luo Z; Liu A; Lu C; Xie Z; Li X
Bioorg Med Chem; 2012 Oct; 20(19):5884-92. PubMed ID: 22944335
[TBL] [Abstract][Full Text] [Related]
29. Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.
Sun Q; Peng DY; Yang SG; Zhu XL; Yang WC; Yang GF
Bioorg Med Chem; 2014 Sep; 22(17):4784-91. PubMed ID: 25088549
[TBL] [Abstract][Full Text] [Related]
30. Design, synthesis, and biological evaluation of new urolithin amides as multitarget agents against Alzheimer's disease.
Shukur KT; Ercetin T; Luise C; Sippl W; Sirkecioglu O; Ulgen M; Coskun GP; Yarim M; Gazi M; Gulcan HO
Arch Pharm (Weinheim); 2021 May; 354(5):e2000467. PubMed ID: 33511649
[TBL] [Abstract][Full Text] [Related]
31. Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.
Zhang C; Du QY; Chen LD; Wu WH; Liao SY; Yu LH; Liang XT
Eur J Med Chem; 2016 Jun; 116():200-209. PubMed ID: 27061983
[TBL] [Abstract][Full Text] [Related]
32. Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Shao D; Zou C; Luo C; Tang X; Li Y
Bioorg Med Chem Lett; 2004 Sep; 14(18):4639-42. PubMed ID: 15324879
[TBL] [Abstract][Full Text] [Related]
33. Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.
Keri RS; Quintanova C; Marques SM; Esteves AR; Cardoso SM; Santos MA
Bioorg Med Chem; 2013 Aug; 21(15):4559-69. PubMed ID: 23768661
[TBL] [Abstract][Full Text] [Related]
34. Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Xu YX; Wang H; Li XK; Dong SN; Liu WW; Gong Q; Wang TD; Tang Y; Zhu J; Li J; Zhang HY; Mao F
Eur J Med Chem; 2018 Jan; 143():33-47. PubMed ID: 29172081
[TBL] [Abstract][Full Text] [Related]
35. Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities.
Chrienova Z; Nepovimova E; Andrys R; Dolezal R; Janockova J; Muckova L; Fabova L; Soukup O; Oleksak P; Valis M; Korabecny J; Marco-Contelles J; Kuca K
J Enzyme Inhib Med Chem; 2022 Dec; 37(1):2605-2620. PubMed ID: 36131624
[TBL] [Abstract][Full Text] [Related]
36. Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Sang Z; Pan W; Wang K; Ma Q; Yu L; Liu W
Bioorg Med Chem; 2017 Jun; 25(12):3006-3017. PubMed ID: 28487125
[TBL] [Abstract][Full Text] [Related]
37. Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.
Hamulakova S; Janovec L; Hrabinova M; Spilovska K; Korabecny J; Kristian P; Kuca K; Imrich J
J Med Chem; 2014 Aug; 57(16):7073-84. PubMed ID: 25089370
[TBL] [Abstract][Full Text] [Related]
38. Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Wang L; Esteban G; Ojima M; Bautista-Aguilera OM; Inokuchi T; Moraleda I; Iriepa I; Samadi A; Youdim MB; Romero A; Soriano E; Herrero R; Fernández Fernández AP; Ricardo-Martínez-Murillo ; Marco-Contelles J; Unzeta M
Eur J Med Chem; 2014 Jun; 80():543-61. PubMed ID: 24813882
[TBL] [Abstract][Full Text] [Related]
39. Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
Chao X; He X; Yang Y; Zhou X; Jin M; Liu S; Cheng Z; Liu P; Wang Y; Yu J; Tan Y; Huang Y; Qin J; Rapposelli S; Pi R
Bioorg Med Chem Lett; 2012 Oct; 22(20):6498-502. PubMed ID: 22981331
[TBL] [Abstract][Full Text] [Related]
40. Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.
Yang X; Qiang X; Li Y; Luo L; Xu R; Zheng Y; Cao Z; Tan Z; Deng Y
Bioorg Chem; 2017 Apr; 71():305-314. PubMed ID: 28267984
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]