These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 23489135)

  • 1. Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
    Wang X; Dong Y; Wittlin S; Charman SA; Chiu FC; Chollet J; Katneni K; Mannila J; Morizzi J; Ryan E; Scheurer C; Steuten J; Santo Tomas J; Snyder C; Vennerstrom JL
    J Med Chem; 2013 Mar; 56(6):2547-55. PubMed ID: 23489135
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
    Zhou L; Alker A; Ruf A; Wang X; Chiu FC; Morizzi J; Charman SA; Charman WN; Scheurer C; Wittlin S; Dong Y; Hunziker D; Vennerstrom JL
    Bioorg Med Chem Lett; 2008 Mar; 18(5):1555-8. PubMed ID: 18262417
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
    Dong Y; Wittlin S; Sriraghavan K; Chollet J; Charman SA; Charman WN; Scheurer C; Urwyler H; Santo Tomas J; Snyder C; Creek DJ; Morizzi J; Koltun M; Matile H; Wang X; Padmanilayam M; Tang Y; Dorn A; Brun R; Vennerstrom JL
    J Med Chem; 2010 Jan; 53(1):481-91. PubMed ID: 19924861
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts
    Giannangelo C; Stingelin L; Yang T; Tilley L; Charman SA; Creek DJ
    Antimicrob Agents Chemother; 2018 Mar; 62(3):. PubMed ID: 29263074
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
    Vennerstrom JL; Fu HN; Ellis WY; Ager AL; Wood JK; Andersen SL; Gerena L; Milhous WK
    J Med Chem; 1992 Aug; 35(16):3023-7. PubMed ID: 1501229
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
    Ellis GL; Amewu R; Sabbani S; Stocks PA; Shone A; Stanford D; Gibbons P; Davies J; Vivas L; Charnaud S; Bongard E; Hall C; Rimmer K; Lozanom S; Jesús M; Gargallo D; Ward SA; O'Neill PM
    J Med Chem; 2008 Apr; 51(7):2170-7. PubMed ID: 18341274
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.
    Wang X; Dong Y; Wittlin S; Creek D; Chollet J; Charman SA; Tomas JS; Scheurer C; Snyder C; Vennerstrom JL
    J Med Chem; 2007 Nov; 50(23):5840-7. PubMed ID: 17949067
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).
    Dong Y; Wang X; Kamaraj S; Bulbule VJ; Chiu FC; Chollet J; Dhanasekaran M; Hein CD; Papastogiannidis P; Morizzi J; Shackleford DM; Barker H; Ryan E; Scheurer C; Tang Y; Zhao Q; Zhou L; White KL; Urwyler H; Charman WN; Matile H; Wittlin S; Charman SA; Vennerstrom JL
    J Med Chem; 2017 Apr; 60(7):2654-2668. PubMed ID: 28052200
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
    Charman SA; Arbe-Barnes S; Bathurst IC; Brun R; Campbell M; Charman WN; Chiu FC; Chollet J; Craft JC; Creek DJ; Dong Y; Matile H; Maurer M; Morizzi J; Nguyen T; Papastogiannidis P; Scheurer C; Shackleford DM; Sriraghavan K; Stingelin L; Tang Y; Urwyler H; Wang X; White KL; Wittlin S; Zhou L; Vennerstrom JL
    Proc Natl Acad Sci U S A; 2011 Mar; 108(11):4400-5. PubMed ID: 21300861
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
    Dong Y; Chollet J; Matile H; Charman SA; Chiu FC; Charman WN; Scorneaux B; Urwyler H; Santo Tomas J; Scheurer C; Snyder C; Dorn A; Wang X; Karle JM; Tang Y; Wittlin S; Brun R; Vennerstrom JL
    J Med Chem; 2005 Jul; 48(15):4953-61. PubMed ID: 16033274
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.
    Bousejra-El Garah F; Wong MH; Amewu RK; Muangnoicharoen S; Maggs JL; Stigliani JL; Park BK; Chadwick J; Ward SA; O'Neill PM
    J Med Chem; 2011 Oct; 54(19):6443-55. PubMed ID: 21888440
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.
    Fügi MA; Wittlin S; Dong Y; Vennerstrom JL
    Antimicrob Agents Chemother; 2010 Mar; 54(3):1042-6. PubMed ID: 20028825
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Endoperoxide Drug Cross-Resistance Patterns for Plasmodium falciparum Exhibiting an Artemisinin Delayed-Clearance Phenotype.
    Siriwardana A; Iyengar K; Roepe PD
    Antimicrob Agents Chemother; 2016 Nov; 60(11):6952-6956. PubMed ID: 27600038
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum.
    Maerki S; Brun R; Charman SA; Dorn A; Matile H; Wittlin S
    J Antimicrob Chemother; 2006 Jul; 58(1):52-8. PubMed ID: 16735432
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.
    Blank BR; Gut J; Rosenthal PJ; Renslo AR
    J Med Chem; 2017 Jul; 60(14):6400-6407. PubMed ID: 28692297
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Antimalarial activity of a synthetic endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum isolates from Gabon.
    Kreidenweiss A; Mordmüller B; Krishna S; Kremsner PG
    Antimicrob Agents Chemother; 2006 Apr; 50(4):1535-7. PubMed ID: 16569877
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.
    Creek DJ; Charman WN; Chiu FC; Prankerd RJ; McCullough KJ; Dong Y; Vennerstrom JL; Charman SA
    J Pharm Sci; 2007 Nov; 96(11):2945-56. PubMed ID: 17549767
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).
    Dong Y; Creek D; Chollet J; Matile H; Charman SA; Wittlin S; Wood JK; Vennerstrom JL
    Antimicrob Agents Chemother; 2007 Aug; 51(8):3033-5. PubMed ID: 17485500
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and antimalarial activity of 3'-trifluoromethylated 1,2,4-trioxolanes and 1,2,4,5-tetraoxane based on deoxycholic acid.
    Yamansarov EY; Kazakov DV; Medvedeva NI; Khusnutdinova EF; Kazakova OB; Legostaeva YV; Ishmuratov GY; Huong LM; Ha TTH; Huong DT; Suponitsky KY
    Steroids; 2018 Jan; 129():17-23. PubMed ID: 29180289
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
    Dong Y; Matile H; Chollet J; Kaminsky R; Wood JK; Vennerstrom JL
    J Med Chem; 1999 Apr; 42(8):1477-80. PubMed ID: 10212135
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.