196 related articles for article (PubMed ID: 23530929)
1. Retinoic acid-elicited RARα/RXRα signaling attenuates Aβ production by directly inhibiting γ-secretase-mediated cleavage of amyloid precursor protein.
Kapoor A; Wang BJ; Hsu WM; Chang MY; Liang SM; Liao YF
ACS Chem Neurosci; 2013 Jul; 4(7):1093-100. PubMed ID: 23530929
[TBL] [Abstract][Full Text] [Related]
2. Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.
Gerber H; Wu F; Dimitrov M; Garcia Osuna GM; Fraering PC
J Biol Chem; 2017 Mar; 292(9):3751-3767. PubMed ID: 28096459
[TBL] [Abstract][Full Text] [Related]
3. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
[TBL] [Abstract][Full Text] [Related]
4. Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway.
Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS
J Biol Chem; 2004 Nov; 279(47):49523-32. PubMed ID: 15347683
[TBL] [Abstract][Full Text] [Related]
5. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
Kokawa A; Ishihara S; Fujiwara H; Nobuhara M; Iwata M; Ihara Y; Funamoto S
Acta Neuropathol Commun; 2015 Nov; 3():66. PubMed ID: 26531305
[TBL] [Abstract][Full Text] [Related]
6. RAGE mediates Aβ accumulation in a mouse model of Alzheimer's disease via modulation of β- and γ-secretase activity.
Fang F; Yu Q; Arancio O; Chen D; Gore SS; Yan SS; Yan SF
Hum Mol Genet; 2018 Mar; 27(6):1002-1014. PubMed ID: 29329433
[TBL] [Abstract][Full Text] [Related]
7. The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase.
Li Y; Li H; Liang W; Li Y; Wang Z
Front Biosci (Landmark Ed); 2024 Feb; 29(2):78. PubMed ID: 38420818
[TBL] [Abstract][Full Text] [Related]
8. Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase.
Jung CG; Uhm KO; Horike H; Kim MJ; Misumi S; Ishida A; Ueda Y; Choi EK; Kim YS; Michikawa M; Hida H
J Alzheimers Dis; 2015; 43(4):1215-28. PubMed ID: 25147119
[TBL] [Abstract][Full Text] [Related]
9. The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.
Zhao J; O'Connor T; Vassar R
J Neuroinflammation; 2011 Nov; 8():150. PubMed ID: 22047170
[TBL] [Abstract][Full Text] [Related]
10. Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice.
Lee JW; Lee YK; Ban JO; Ha TY; Yun YP; Han SB; Oh KW; Hong JT
J Nutr; 2009 Oct; 139(10):1987-93. PubMed ID: 19656855
[TBL] [Abstract][Full Text] [Related]
11. Revisiting APP secretases: an overview on the holistic effects of retinoic acid receptor stimulation in APP processing.
Vitória JJM; Trigo D; da Cruz E Silva OAB
Cell Mol Life Sci; 2022 Jan; 79(2):101. PubMed ID: 35089425
[TBL] [Abstract][Full Text] [Related]
12. Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation.
Jin C; Wang J; Wang Y; Jia B; Guo X; Yang G; Xu P; Greengard P; Zhou R; Shi Y
Proc Natl Acad Sci U S A; 2022 Mar; 119(12):e2122292119. PubMed ID: 35298330
[TBL] [Abstract][Full Text] [Related]
13. The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides.
Siegel G; Gerber H; Koch P; Bruestle O; Fraering PC; Rajendran L
Cell Rep; 2017 Jun; 19(10):1967-1976. PubMed ID: 28591569
[TBL] [Abstract][Full Text] [Related]
14. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
[TBL] [Abstract][Full Text] [Related]
15. Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase.
Winkler E; Julius A; Steiner H; Langosch D
Biochemistry; 2015 Oct; 54(40):6149-52. PubMed ID: 26403946
[TBL] [Abstract][Full Text] [Related]
16. Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons.
Maesako M; Houser MCQ; Turchyna Y; Wolfe MS; Berezovska O
J Neurosci; 2022 Jan; 42(1):145-154. PubMed ID: 34810230
[TBL] [Abstract][Full Text] [Related]
17. A cellular model of amyloid precursor protein processing and amyloid-β peptide production.
Macias MP; Gonzales AM; Siniard AL; Walker AW; Corneveaux JJ; Huentelman MJ; Sabbagh MN; Decourt B
J Neurosci Methods; 2014 Feb; 223():114-22. PubMed ID: 24333289
[TBL] [Abstract][Full Text] [Related]
18. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
Liu L; Lauro BM; Wolfe MS; Selkoe DJ
J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
[TBL] [Abstract][Full Text] [Related]
19. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.
Corbett GT; Gonzalez FJ; Pahan K
Proc Natl Acad Sci U S A; 2015 Jul; 112(27):8445-50. PubMed ID: 26080426
[TBL] [Abstract][Full Text] [Related]
20. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
Pinnix I; Ghiso JA; Pappolla MA; Sambamurti K
Am J Geriatr Psychiatry; 2013 May; 21(5):474-83. PubMed ID: 23570890
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]