BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1243 related articles for article (PubMed ID: 23539183)

  • 1. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.
    Lewis PW; Müller MM; Koletsky MS; Cordero F; Lin S; Banaszynski LA; Garcia BA; Muir TW; Becher OJ; Allis CD
    Science; 2013 May; 340(6134):857-61. PubMed ID: 23539183
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.
    Venneti S; Garimella MT; Sullivan LM; Martinez D; Huse JT; Heguy A; Santi M; Thompson CB; Judkins AR
    Brain Pathol; 2013 Sep; 23(5):558-64. PubMed ID: 23414300
    [TBL] [Abstract][Full Text] [Related]  

  • 3. EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
    Mohammad F; Weissmann S; Leblanc B; Pandey DP; Højfeldt JW; Comet I; Zheng C; Johansen JV; Rapin N; Porse BT; Tvardovskiy A; Jensen ON; Olaciregui NG; Lavarino C; Suñol M; de Torres C; Mora J; Carcaboso AM; Helin K
    Nat Med; 2017 Apr; 23(4):483-492. PubMed ID: 28263309
    [TBL] [Abstract][Full Text] [Related]  

  • 4. H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.
    Harutyunyan AS; Krug B; Chen H; Papillon-Cavanagh S; Zeinieh M; De Jay N; Deshmukh S; Chen CCL; Belle J; Mikael LG; Marchione DM; Li R; Nikbakht H; Hu B; Cagnone G; Cheung WA; Mohammadnia A; Bechet D; Faury D; McConechy MK; Pathania M; Jain SU; Ellezam B; Weil AG; Montpetit A; Salomoni P; Pastinen T; Lu C; Lewis PW; Garcia BA; Kleinman CL; Jabado N; Majewski J
    Nat Commun; 2019 Mar; 10(1):1262. PubMed ID: 30890717
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.
    Bender S; Tang Y; Lindroth AM; Hovestadt V; Jones DT; Kool M; Zapatka M; Northcott PA; Sturm D; Wang W; Radlwimmer B; Højfeldt JW; Truffaux N; Castel D; Schubert S; Ryzhova M; Seker-Cin H; Gronych J; Johann PD; Stark S; Meyer J; Milde T; Schuhmann M; Ebinger M; Monoranu CM; Ponnuswami A; Chen S; Jones C; Witt O; Collins VP; von Deimling A; Jabado N; Puget S; Grill J; Helin K; Korshunov A; Lichter P; Monje M; Plass C; Cho YJ; Pfister SM
    Cancer Cell; 2013 Nov; 24(5):660-72. PubMed ID: 24183680
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
    Justin N; Zhang Y; Tarricone C; Martin SR; Chen S; Underwood E; De Marco V; Haire LF; Walker PA; Reinberg D; Wilson JR; Gamblin SJ
    Nat Commun; 2016 Apr; 7():11316. PubMed ID: 27121947
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo?
    Chan KM; Han J; Fang D; Gan H; Zhang Z
    Cell Cycle; 2013 Aug; 12(16):2546-52. PubMed ID: 23907119
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
    Brien GL; Bressan RB; Monger C; Gannon D; Lagan E; Doherty AM; Healy E; Neikes H; Fitzpatrick DJ; Deevy O; Grant V; Marqués-Torrejón MA; Alfazema N; Pollard SM; Bracken AP
    Nat Genet; 2021 Aug; 53(8):1221-1232. PubMed ID: 34294917
    [TBL] [Abstract][Full Text] [Related]  

  • 9. EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.
    Hübner JM; Müller T; Papageorgiou DN; Mauermann M; Krijgsveld J; Russell RB; Ellison DW; Pfister SM; Pajtler KW; Kool M
    Neuro Oncol; 2019 Jul; 21(7):878-889. PubMed ID: 30923826
    [TBL] [Abstract][Full Text] [Related]  

  • 10. No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3.
    Wiese M; Schill F; Sturm D; Pfister S; Hulleman E; Johnsen SA; Kramm CM
    Klin Padiatr; 2016 Apr; 228(3):113-7. PubMed ID: 27135271
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas.
    Venneti S; Santi M; Felicella MM; Yarilin D; Phillips JJ; Sullivan LM; Martinez D; Perry A; Lewis PW; Thompson CB; Judkins AR
    Acta Neuropathol; 2014 Nov; 128(5):743-53. PubMed ID: 25200322
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma.
    Lee CH; Yu JR; Granat J; Saldaña-Meyer R; Andrade J; LeRoy G; Jin Y; Lund P; Stafford JM; Garcia BA; Ueberheide B; Reinberg D
    Genes Dev; 2019 Oct; 33(19-20):1428-1440. PubMed ID: 31488577
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Immunostaining of Increased Expression of Enhancer of Zeste Homolog 2 (EZH2) in Diffuse Midline Glioma H3K27M-Mutant Patients with Poor Survival.
    Karlowee V; Amatya VJ; Takayasu T; Takano M; Yonezawa U; Takeshima Y; Sugiyama K; Kurisu K; Yamasaki F
    Pathobiology; 2019; 86(2-3):152-161. PubMed ID: 31096221
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.
    Jain SU; Khazaei S; Marchione DM; Lundgren SM; Wang X; Weinberg DN; Deshmukh S; Juretic N; Lu C; Allis CD; Garcia BA; Jabado N; Lewis PW
    Proc Natl Acad Sci U S A; 2020 Nov; 117(44):27354-27364. PubMed ID: 33067396
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.
    Herz HM; Morgan M; Gao X; Jackson J; Rickels R; Swanson SK; Florens L; Washburn MP; Eissenberg JC; Shilatifard A
    Science; 2014 Aug; 345(6200):1065-70. PubMed ID: 25170156
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis.
    Shi L; Shi J; Shi X; Li W; Wen H
    J Mol Biol; 2018 May; 430(11):1562-1565. PubMed ID: 29689253
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In silico analysis of histone H3 gene expression during human brain development.
    Ren M; van Nocker S
    Int J Dev Biol; 2016; 60(4-6):167-73. PubMed ID: 27251074
    [TBL] [Abstract][Full Text] [Related]  

  • 18. H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape.
    Furth N; Algranati D; Dassa B; Beresh O; Fedyuk V; Morris N; Kasper LH; Jones D; Monje M; Baker SJ; Shema E
    Cell Rep; 2022 May; 39(7):110836. PubMed ID: 35584667
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.
    Piunti A; Hashizume R; Morgan MA; Bartom ET; Horbinski CM; Marshall SA; Rendleman EJ; Ma Q; Takahashi YH; Woodfin AR; Misharin AV; Abshiru NA; Lulla RR; Saratsis AM; Kelleher NL; James CD; Shilatifard A
    Nat Med; 2017 Apr; 23(4):493-500. PubMed ID: 28263307
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma.
    Natsume A; Ito M; Katsushima K; Ohka F; Hatanaka A; Shinjo K; Sato S; Takahashi S; Ishikawa Y; Takeuchi I; Shimogawa H; Uesugi M; Okano H; Kim SU; Wakabayashi T; Issa JP; Sekido Y; Kondo Y
    Cancer Res; 2013 Jul; 73(14):4559-70. PubMed ID: 23720055
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 63.