These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

194 related articles for article (PubMed ID: 23540839)

  • 1. Small molecule regulation of protein conformation by binding in the Flap of HIV protease.
    Tiefenbrunn T; Forli S; Baksh MM; Chang MW; Happer M; Lin YC; Perryman AL; Rhee JK; Torbett BE; Olson AJ; Elder JH; Finn MG; Stout CD
    ACS Chem Biol; 2013; 8(6):1223-31. PubMed ID: 23540839
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The effect of inhibitor binding on the structural stability and cooperativity of the HIV-1 protease.
    Todd MJ; Freire E
    Proteins; 1999 Aug; 36(2):147-56. PubMed ID: 10398363
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Fragment-based screen against HIV protease.
    Perryman AL; Zhang Q; Soutter HH; Rosenfeld R; McRee DE; Olson AJ; Elder JE; Stout CD
    Chem Biol Drug Des; 2010 Mar; 75(3):257-68. PubMed ID: 20659109
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Flap-site Fragment Restores Back Wild-type Behaviour in Resistant Form of HIV Protease.
    Luchi A; Angelina E; Bogado L; Forli S; Olson A; Peruchena N
    Mol Inform; 2018 Dec; 37(12):e1800053. PubMed ID: 30051611
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Integrating Multiple Receptor Conformation Docking and Multi Dimensional QSAR for Enhancing Accuracy of Binding Affinity Prediction.
    Radhika V; Jaraf HA; Kanth SS; Vijjulatha M
    Curr Comput Aided Drug Des; 2017; 13(2):127-142. PubMed ID: 28103770
    [TBL] [Abstract][Full Text] [Related]  

  • 6. New active HIV-1 protease inhibitors derived from 3-hexanol: conformation study of the free inhibitors in crystalline state and in complex with the enzyme.
    Ziółkowska NE; Bujacz A; Randad RS; Erickson JW; Skálová T; Hašek J; Bujacz G
    Chem Biol Drug Des; 2012 May; 79(5):798-809. PubMed ID: 22296826
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identifying the molecular mechanics and binding dynamics characteristics of potent inhibitors to HIV-1 protease.
    Li D; Liu MS; Ji B; Hwang KC; Huang Y
    Chem Biol Drug Des; 2012 Sep; 80(3):440-54. PubMed ID: 22621379
    [TBL] [Abstract][Full Text] [Related]  

  • 8. HIV-1 protease flaps spontaneously close to the correct structure in simulations following manual placement of an inhibitor into the open state.
    Hornak V; Okur A; Rizzo RC; Simmerling C
    J Am Chem Soc; 2006 Mar; 128(9):2812-3. PubMed ID: 16506755
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation.
    Liu F; Kovalevsky AY; Louis JM; Boross PI; Wang YF; Harrison RW; Weber IT
    J Mol Biol; 2006 May; 358(5):1191-9. PubMed ID: 16569415
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Enamino-oxindole HIV protease inhibitors.
    Eissenstat M; Guerassina T; Gulnik S; Afonina E; Silva AM; Ludtke D; Yokoe H; Yu B; Erickson J
    Bioorg Med Chem Lett; 2012 Aug; 22(15):5078-83. PubMed ID: 22749283
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.
    Ghosh AK; Brindisi M; Nyalapatla PR; Takayama J; Ella-Menye JR; Yashchuk S; Agniswamy J; Wang YF; Aoki M; Amano M; Weber IT; Mitsuya H
    Bioorg Med Chem; 2017 Oct; 25(19):5114-5127. PubMed ID: 28434781
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of allosteric molecules on structure and drug affinity of HIV-1 protease by molecular dynamics simulations.
    Meng XM; Hu WJ; Mu YG; Sheng XH
    J Mol Graph Model; 2016 Nov; 70():153-162. PubMed ID: 27723563
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Solution structure of HIV-1 protease flaps probed by comparison of molecular dynamics simulation ensembles and EPR experiments.
    Ding F; Layten M; Simmerling C
    J Am Chem Soc; 2008 Jun; 130(23):7184-5. PubMed ID: 18479129
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.
    Yedidi RS; Liu Z; Wang Y; Brunzelle JS; Kovari IA; Woster PM; Kovari LC; Gupta D
    Biochem Biophys Res Commun; 2012 May; 421(3):413-7. PubMed ID: 22469467
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Exploring the flap dynamics of the South African HIV subtype C protease in presence of FDA-approved inhibitors: MD study.
    Maphumulo SI; Halder AK; Govender T; Maseko S; Maguire GEM; Honarparvar B; Kruger HG
    Chem Biol Drug Des; 2018 Nov; 92(5):1899-1913. PubMed ID: 30003668
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Binding of single walled carbon nanotube to WT and mutant HIV-1 proteases: analysis of flap dynamics and binding mechanism.
    Meher BR; Wang Y
    J Mol Graph Model; 2012 Sep; 38():430-45. PubMed ID: 23142620
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance.
    Naicker P; Achilonu I; Fanucchi S; Fernandes M; Ibrahim MA; Dirr HW; Soliman ME; Sayed Y
    J Biomol Struct Dyn; 2013 Dec; 31(12):1370-80. PubMed ID: 23140382
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Computational analysis of HIV-1 protease protein binding pockets.
    Ko GM; Reddy AS; Kumar S; Bailey BA; Garg R
    J Chem Inf Model; 2010 Oct; 50(10):1759-71. PubMed ID: 20925403
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters.
    Shen CH; Wang YF; Kovalevsky AY; Harrison RW; Weber IT
    FEBS J; 2010 Sep; 277(18):3699-714. PubMed ID: 20695887
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Active site binding modes of curcumin in HIV-1 protease and integrase.
    Vajragupta O; Boonchoong P; Morris GM; Olson AJ
    Bioorg Med Chem Lett; 2005 Jul; 15(14):3364-8. PubMed ID: 15950462
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.