BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

180 related articles for article (PubMed ID: 23545530)

  • 1. Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants.
    Cody V; Pace J; Queener SF; Adair OO; Gangjee A
    Antimicrob Agents Chemother; 2013 Jun; 57(6):2669-77. PubMed ID: 23545530
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.
    Cody V; Pace J; Makin J; Piraino J; Queener SF; Rosowsky A
    Biochemistry; 2009 Mar; 48(8):1702-11. PubMed ID: 19196009
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.
    Cody V; Pace J; Namjoshi OA; Gangjee A
    Acta Crystallogr F Struct Biol Commun; 2015 Jun; 71(Pt 6):799-803. PubMed ID: 26057816
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.
    Cody V; Pace J; Piraino J; Queener SF
    J Struct Biol; 2011 Oct; 176(1):52-9. PubMed ID: 21684339
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.
    Shah K; Queener S; Cody V; Pace J; Gangjee A
    Bioorg Med Chem Lett; 2019 Aug; 29(15):1874-1880. PubMed ID: 31176699
    [TBL] [Abstract][Full Text] [Related]  

  • 6. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
    Rosowsky A; Forsch RA; Sibley CH; Inderlied CB; Queener SF
    J Med Chem; 2004 Mar; 47(6):1475-86. PubMed ID: 14998335
    [TBL] [Abstract][Full Text] [Related]  

  • 7. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.
    Cody V; Pace J; Chisum K; Rosowsky A
    Proteins; 2006 Dec; 65(4):959-69. PubMed ID: 17019704
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.
    Shah K; Lin X; Queener SF; Cody V; Pace J; Gangjee A
    Bioorg Med Chem; 2018 May; 26(9):2640-2650. PubMed ID: 29691153
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.
    Cody V; Luft JR; Pangborn W; Gangjee A; Queener SF
    Acta Crystallogr D Biol Crystallogr; 2004 Apr; 60(Pt 4):646-55. PubMed ID: 15039552
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives.
    Cody V; Pace J
    Acta Crystallogr D Biol Crystallogr; 2011 Jan; 67(Pt 1):1-7. PubMed ID: 21206056
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
    Gangjee A; Adair OO; Queener SF
    J Med Chem; 2003 Nov; 46(23):5074-82. PubMed ID: 14584957
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
    Chan DC; Fu H; Forsch RA; Queener SF; Rosowsky A
    J Med Chem; 2005 Jun; 48(13):4420-31. PubMed ID: 15974594
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dihydrofolate reductase from the pathogenic fungus Pneumocystis carinii: catalytic properties and interaction with antifolates.
    Margosiak SA; Appleman JR; Santi DV; Blakley RL
    Arch Biochem Biophys; 1993 Sep; 305(2):499-508. PubMed ID: 8373187
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
    Gangjee A; Vasudevan A; Queener SF; Kisliuk RL
    J Med Chem; 1996 Mar; 39(7):1438-46. PubMed ID: 8691474
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode.
    Cody V; Pace J; Nowak J
    Acta Crystallogr D Biol Crystallogr; 2011 Oct; 67(Pt 10):875-80. PubMed ID: 21931219
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium.
    Forsch RA; Queener SF; Rosowsky A
    Bioorg Med Chem Lett; 2004 Apr; 14(7):1811-5. PubMed ID: 15026078
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
    Gangjee A; Namjoshi OA; Raghavan S; Queener SF; Kisliuk RL; Cody V
    J Med Chem; 2013 Jun; 56(11):4422-41. PubMed ID: 23627352
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
    Rosowsky A; Forsch RA; Queener SF
    J Med Chem; 2003 Apr; 46(9):1726-36. PubMed ID: 12699390
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.
    Rosowsky A; Forsch RA; Queener SF
    J Med Chem; 2002 Jan; 45(1):233-41. PubMed ID: 11754594
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.
    Gangjee A; Zhu Y; Queener SF
    J Med Chem; 1998 Nov; 41(23):4533-41. PubMed ID: 9804692
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.