146 related articles for article (PubMed ID: 2354716)
1. Characterization of dihydrofolate reductase of Pneumocystis carinii and Toxoplasma gondii.
Kovacs JA; Allegra CJ; Masur H
Exp Parasitol; 1990 Jul; 71(1):60-8. PubMed ID: 2354716
[TBL] [Abstract][Full Text] [Related]
2. Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Piper JR; Johnson CA; Krauth CA; Carter RL; Hosmer CA; Queener SF; Borotz SE; Pfefferkorn ER
J Med Chem; 1996 Mar; 39(6):1271-80. PubMed ID: 8632434
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.
Rosowsky A; Forsch RA; Queener SF
J Med Chem; 2002 Jan; 45(1):233-41. PubMed ID: 11754594
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
Rosowsky A; Papoulis AT; Forsch RA; Queener SF
J Med Chem; 1999 Mar; 42(6):1007-17. PubMed ID: 10090784
[TBL] [Abstract][Full Text] [Related]
5. 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Rosowsky A; Papoulis AT; Queener SF
J Med Chem; 1998 Mar; 41(6):913-8. PubMed ID: 9526565
[TBL] [Abstract][Full Text] [Related]
6. Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii.
Trujillo M; Donald RG; Roos DS; Greene PJ; Santi DV
Biochemistry; 1996 May; 35(20):6366-74. PubMed ID: 8639582
[TBL] [Abstract][Full Text] [Related]
7. 2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii.
Rosowsky A; Forsch RA; Queener SF
J Med Chem; 1995 Jul; 38(14):2615-20. PubMed ID: 7629801
[TBL] [Abstract][Full Text] [Related]
8. First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling.
Sharma H; Landau MJ; Vargo MA; Spasov KA; Anderson KS
Biochemistry; 2013 Oct; 52(41):7305-7317. PubMed ID: 24053355
[TBL] [Abstract][Full Text] [Related]
9. 2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Rosowsky A; Papoulis AT; Queener SF
J Med Chem; 1997 Oct; 40(22):3694-9. PubMed ID: 9357537
[TBL] [Abstract][Full Text] [Related]
10. 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Rosowsky A; Mota CE; Queener SF; Waltham M; Ercikan-Abali E; Bertino JR
J Med Chem; 1995 Mar; 38(5):745-52. PubMed ID: 7877140
[TBL] [Abstract][Full Text] [Related]
11. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Robson C; Meek MA; Grunwaldt JD; Lambert PA; Queener SF; Schmidt D; Griffin RJ
J Med Chem; 1997 Sep; 40(19):3040-8. PubMed ID: 9301666
[TBL] [Abstract][Full Text] [Related]
12. Toward rational design of species-specific inhibitors of Pneumocystis carinii thymidylate synthase and Toxoplasma gondii dihydrofolate reductase-thymidylate synthase.
Peaslee KA; Anderson AC
J Eukaryot Microbiol; 2001; Suppl():174S-175S. PubMed ID: 11906050
[No Abstract] [Full Text] [Related]
13. Synthesis of new 2,4-Diaminopyrido[2,3-d]pyrimidine and 2,4-Diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
Rosowsky A; Chen H; Fu H; Queener SF
Bioorg Med Chem; 2003 Jan; 11(1):59-67. PubMed ID: 12467708
[TBL] [Abstract][Full Text] [Related]
14. Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Rosowsky A; Hynes JB; Queener SF
Antimicrob Agents Chemother; 1995 Jan; 39(1):79-86. PubMed ID: 7695334
[TBL] [Abstract][Full Text] [Related]
15. Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity.
Johnson EF; Hinz W; Atreya CE; Maley F; Anderson KS
J Biol Chem; 2002 Nov; 277(45):43126-36. PubMed ID: 12192007
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of dihydrofolate reductases from Toxoplasma gondii, Pneumocystis carinii, and rat liver by rotationally restricted analogues of pyrimethamine and metoprine.
Rosowsky A; Queener SF; Cody V
Drug Des Discov; 1999 Jul; 16(1):25-40. PubMed ID: 10466054
[TBL] [Abstract][Full Text] [Related]
17. Primary structure of the dihydrofolate reductase-thymidylate synthase gene from Toxoplasma gondii.
Roos DS
J Biol Chem; 1993 Mar; 268(9):6269-80. PubMed ID: 8454599
[TBL] [Abstract][Full Text] [Related]
18. Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase.
Ma L; Kovacs JA
Antimicrob Agents Chemother; 2000 Nov; 44(11):3092-6. PubMed ID: 11036028
[TBL] [Abstract][Full Text] [Related]
19. Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation.
Landau MJ; Sharma H; Anderson KS
Protein Sci; 2013 Sep; 22(9):1161-73. PubMed ID: 23813474
[TBL] [Abstract][Full Text] [Related]
20. Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
Rosowsky A; Fu H; Chan DC; Queener SF
J Med Chem; 2004 May; 47(10):2475-85. PubMed ID: 15115391
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]