These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

274 related articles for article (PubMed ID: 23549610)

  • 1. The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.
    Ren Z; Yan L; Zhang N; Guo Y; Yang C; Lou Z; Rao Z
    Protein Cell; 2013 Apr; 4(4):248-50. PubMed ID: 23549610
    [No Abstract]   [Full Text] [Related]  

  • 2. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs.
    Anand K; Ziebuhr J; Wadhwani P; Mesters JR; Hilgenfeld R
    Science; 2003 Jun; 300(5626):1763-7. PubMed ID: 12746549
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Drug design targeting the main protease, the Achilles' heel of coronaviruses.
    Yang H; Bartlam M; Rao Z
    Curr Pharm Des; 2006; 12(35):4573-90. PubMed ID: 17168763
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
    Matthews DA; Dragovich PS; Webber SE; Fuhrman SA; Patick AK; Zalman LS; Hendrickson TF; Love RA; Prins TJ; Marakovits JT; Zhou R; Tikhe J; Ford CE; Meador JW; Ferre RA; Brown EL; Binford SL; Brothers MA; DeLisle DM; Worland ST
    Proc Natl Acad Sci U S A; 1999 Sep; 96(20):11000-7. PubMed ID: 10500114
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors.
    Lee CC; Kuo CJ; Hsu MF; Liang PH; Fang JM; Shie JJ; Wang AH
    FEBS Lett; 2007 Nov; 581(28):5454-8. PubMed ID: 17981158
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.
    Chen L; Gui C; Luo X; Yang Q; Günther S; Scandella E; Drosten C; Bai D; He X; Ludewig B; Chen J; Luo H; Yang Y; Yang Y; Zou J; Thiel V; Chen K; Shen J; Shen X; Jiang H
    J Virol; 2005 Jun; 79(11):7095-103. PubMed ID: 15890949
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase.
    Yin J; Niu C; Cherney MM; Zhang J; Huitema C; Eltis LD; Vederas JC; James MN
    J Mol Biol; 2007 Aug; 371(4):1060-74. PubMed ID: 17599357
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease.
    Shie JJ; Fang JM; Kuo CJ; Kuo TH; Liang PH; Huang HJ; Yang WB; Lin CH; Chen JL; Wu YT; Wong CH
    J Med Chem; 2005 Jun; 48(13):4469-73. PubMed ID: 15974598
    [TBL] [Abstract][Full Text] [Related]  

  • 9. New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.
    Regnier T; Sarma D; Hidaka K; Bacha U; Freire E; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2009 May; 19(10):2722-7. PubMed ID: 19362479
    [TBL] [Abstract][Full Text] [Related]  

  • 10. High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase.
    Blanchard JE; Elowe NH; Huitema C; Fortin PD; Cechetto JD; Eltis LD; Brown ED
    Chem Biol; 2004 Oct; 11(10):1445-53. PubMed ID: 15489171
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.
    Zhou L; Liu Y; Zhang W; Wei P; Huang C; Pei J; Yuan Y; Lai L
    J Med Chem; 2006 Jun; 49(12):3440-3. PubMed ID: 16759084
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications.
    Lee H; Cao S; Hevener KE; Truong L; Gatuz JL; Patel K; Ghosh AK; Johnson ME
    ChemMedChem; 2013 Aug; 8(8):1361-72. PubMed ID: 23788528
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors.
    Chen LR; Wang YC; Lin YW; Chou SY; Chen SF; Liu LT; Wu YT; Kuo CJ; Chen TS; Juang SH
    Bioorg Med Chem Lett; 2005 Jun; 15(12):3058-62. PubMed ID: 15896959
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The interaction between severe acute respiratory syndrome coronavirus 3C-like proteinase and a dimeric inhibitor by capillary electrophoresis.
    Ding L; Zhang XX; Wei P; Fan K; Lai L
    Anal Biochem; 2005 Aug; 343(1):159-65. PubMed ID: 15935325
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease.
    Binford SL; Weady PT; Maldonado F; Brothers MA; Matthews DA; Patick AK
    Antimicrob Agents Chemother; 2007 Dec; 51(12):4366-73. PubMed ID: 17908951
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study.
    Ang MJ; Lau QY; Ng FM; Then SW; Poulsen A; Cheong YK; Ngoh ZX; Tan YW; Peng J; Keller TH; Hill J; Chu JJ; Chia CS
    J Enzyme Inhib Med Chem; 2016; 31(2):332-9. PubMed ID: 25792507
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease.
    Shao YM; Yang WB; Kuo TH; Tsai KC; Lin CH; Yang AS; Liang PH; Wong CH
    Bioorg Med Chem; 2008 Apr; 16(8):4652-60. PubMed ID: 18329272
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme.
    Chen X; Chou CY; Chang GG
    Antivir Chem Chemother; 2009; 19(4):151-6. PubMed ID: 19374142
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters.
    Shie JJ; Fang JM; Kuo TH; Kuo CJ; Liang PH; Huang HJ; Wu YT; Jan JT; Cheng YS; Wong CH
    Bioorg Med Chem; 2005 Sep; 13(17):5240-52. PubMed ID: 15994085
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase.
    Lai L; Han X; Chen H; Wei P; Huang C; Liu S; Fan K; Zhou L; Liu Z; Pei J; Liu Y
    Curr Pharm Des; 2006; 12(35):4555-64. PubMed ID: 17168761
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.