295 related articles for article (PubMed ID: 23558010)
1. Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans.
Maciejewski BS; LaPerle JL; Chen D; Ghosh A; Zavadoski WJ; McDonald TS; Manion TB; Mather D; Patterson TA; Hanna M; Watkins S; Gibbs EM; Calle RA; Steppan CM
Am J Physiol Gastrointest Liver Physiol; 2013 Jun; 304(11):G958-69. PubMed ID: 23558010
[TBL] [Abstract][Full Text] [Related]
2. A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity.
Yamamoto T; Yamaguchi H; Miki H; Kitamura S; Nakada Y; Aicher TD; Pratt SA; Kato K
Eur J Pharmacol; 2011 Jan; 650(2-3):663-72. PubMed ID: 21034741
[TBL] [Abstract][Full Text] [Related]
3. Pharmacological characterization of [trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl CoA:diacylglycerol transferase (DGAT) 1 inhibitor.
Tomimoto D; Okuma C; Ishii Y; Akiyama Y; Ohta T; Kakutani M; Ohkuma Y; Ogawa N
Biol Pharm Bull; 2015; 38(2):263-9. PubMed ID: 25747985
[TBL] [Abstract][Full Text] [Related]
4. Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption.
Cheng D; Iqbal J; Devenny J; Chu CH; Chen L; Dong J; Seethala R; Keim WJ; Azzara AV; Lawrence RM; Pelleymounter MA; Hussain MM
J Biol Chem; 2008 Oct; 283(44):29802-11. PubMed ID: 18768481
[TBL] [Abstract][Full Text] [Related]
5. Coenzyme A: diacylglycerol acyltransferase 1 inhibitor ameliorates obesity, liver steatosis, and lipid metabolism abnormality in KKAy mice fed high-fat or high-carbohydrate diets.
Yamamoto T; Yamaguchi H; Miki H; Shimada M; Nakada Y; Ogino M; Asano K; Aoki K; Tamura N; Masago M; Kato K
Eur J Pharmacol; 2010 Aug; 640(1-3):243-9. PubMed ID: 20478303
[TBL] [Abstract][Full Text] [Related]
6. Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- mice.
Lee B; Fast AM; Zhu J; Cheng JX; Buhman KK
J Lipid Res; 2010 Jul; 51(7):1770-80. PubMed ID: 20147738
[TBL] [Abstract][Full Text] [Related]
7. Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.
Liu J; Gorski JN; Gold SJ; Chen D; Chen S; Forrest G; Itoh Y; Marsh DJ; McLaren DG; Shen Z; Sonatore L; Carballo-Jane E; Craw S; Guan X; Karanam B; Sakaki J; Szeto D; Tong X; Xiao J; Yoshimoto R; Yu H; Roddy TP; Balkovec J; Pinto S
Obesity (Silver Spring); 2013 Jul; 21(7):1406-15. PubMed ID: 23671037
[TBL] [Abstract][Full Text] [Related]
8. Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat.
Hung YH; Carreiro AL; Buhman KK
Biochim Biophys Acta Mol Cell Biol Lipids; 2017 Jun; 1862(6):600-614. PubMed ID: 28249764
[TBL] [Abstract][Full Text] [Related]
9. Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Sachdev V; Leopold C; Bauer R; Patankar JV; Iqbal J; Obrowsky S; Boverhof R; Doktorova M; Scheicher B; Goeritzer M; Kolb D; Turnbull AV; Zimmer A; Hoefler G; Hussain MM; Groen AK; Kratky D
Biochim Biophys Acta; 2016 Sep; 1861(9 Pt A):1132-1141. PubMed ID: 27344248
[TBL] [Abstract][Full Text] [Related]
10. Diacylglycerol acyltransferase 1/2 inhibition induces dysregulation of fatty acid metabolism and leads to intestinal barrier failure and diarrhea in mice.
Takemoto K; Fukasaka Y; Yoshimoto R; Nambu H; Yukioka H
Physiol Rep; 2020 Aug; 8(15):e14542. PubMed ID: 32786057
[TBL] [Abstract][Full Text] [Related]
11. DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis.
Buhman KK; Smith SJ; Stone SJ; Repa JJ; Wong JS; Knapp FF; Burri BJ; Hamilton RL; Abumrad NA; Farese RV
J Biol Chem; 2002 Jul; 277(28):25474-9. PubMed ID: 11959864
[TBL] [Abstract][Full Text] [Related]
12. DGAT1 deficiency disrupts lysosome function in enterocytes during dietary fat absorption.
Hung YH; Buhman KK
Biochim Biophys Acta Mol Cell Biol Lipids; 2019 Apr; 1864(4):587-595. PubMed ID: 30342099
[TBL] [Abstract][Full Text] [Related]
13. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases.
Cao J; Zhou Y; Peng H; Huang X; Stahler S; Suri V; Qadri A; Gareski T; Jones J; Hahm S; Perreault M; McKew J; Shi M; Xu X; Tobin JF; Gimeno RE
J Biol Chem; 2011 Dec; 286(48):41838-41851. PubMed ID: 21990351
[TBL] [Abstract][Full Text] [Related]
14. Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying.
Ables GP; Yang KJ; Vogel S; Hernandez-Ono A; Yu S; Yuen JJ; Birtles S; Buckett LK; Turnbull AV; Goldberg IJ; Blaner WS; Huang LS; Ginsberg HN
J Lipid Res; 2012 Nov; 53(11):2364-79. PubMed ID: 22911105
[TBL] [Abstract][Full Text] [Related]
15. Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model.
Yu T; Wu C; Shih N; Li Q; Chan C; Pan H; Yao D; Pan Y; Liang W; Shen L; Zhao H; Li J; Chen S
Bioorg Med Chem Lett; 2018 Jun; 28(10):1686-1692. PubMed ID: 29699923
[TBL] [Abstract][Full Text] [Related]
16. Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.
Kadam KS; Jadhav RD; Kandre S; Guha T; Reddy MM; Brahma MK; Deshmukh NJ; Dixit A; Doshi L; Srinivasan S; Devle J; Damre A; Nemmani KV; Gupte A; Sharma R
Eur J Med Chem; 2013 Jul; 65():337-47. PubMed ID: 23735282
[TBL] [Abstract][Full Text] [Related]
17. Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.
Chandak PG; Obrowsky S; Radovic B; Doddapattar P; Aflaki E; Kratzer A; Doshi LS; Povoden S; Ahammer H; Hoefler G; Levak-Frank S; Kratky D
Biochim Biophys Acta; 2011 Dec; 1811(12):1011-20. PubMed ID: 21924378
[TBL] [Abstract][Full Text] [Related]
18. Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.
Fox BM; Sugimoto K; Iio K; Yoshida A; Zhang JK; Li K; Hao X; Labelle M; Smith ML; Rubenstein SM; Ye G; McMinn D; Jackson S; Choi R; Shan B; Ma J; Miao S; Matsui T; Ogawa N; Suzuki M; Kobayashi A; Ozeki H; Okuma C; Ishii Y; Tomimoto D; Furakawa N; Tanaka M; Matsushita M; Takahashi M; Inaba T; Sagawa S; Kayser F
J Med Chem; 2014 Apr; 57(8):3464-83. PubMed ID: 24670009
[TBL] [Abstract][Full Text] [Related]
19. In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia.
King AJ; Segreti JA; Larson KJ; Souers AJ; Kym PR; Reilly RM; Collins CA; Voorbach MJ; Zhao G; Mittelstadt SW; Cox BF
Eur J Pharmacol; 2010 Jul; 637(1-3):155-61. PubMed ID: 20385122
[TBL] [Abstract][Full Text] [Related]
20. Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes.
Li C; Li L; Lian J; Watts R; Nelson R; Goodwin B; Lehner R
Arterioscler Thromb Vasc Biol; 2015 May; 35(5):1080-91. PubMed ID: 25792450
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
