These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 23567074)

  • 1. Translational pharmacokinetic-pharmacodynamic modeling of QTc effects in dog and human.
    Parkinson J; Visser SA; Jarvis P; Pollard C; Valentin JP; Yates JW; Ewart L
    J Pharmacol Toxicol Methods; 2013; 68(3):357-66. PubMed ID: 23567074
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs.
    Ollerstam A; Visser SA; Duker G; Forsberg T; Persson AH; Nilsson LB; Björkman JA; Gabrielsson J; Al-Saffar A
    J Pharmacol Toxicol Methods; 2007; 56(2):131-44. PubMed ID: 17689270
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys.
    Watson KJ; Gorczyca WP; Umland J; Zhang Y; Chen X; Sun SZ; Fermini B; Holbrook M; Van Der Graaf PH
    J Pharmacol Toxicol Methods; 2011; 63(3):304-13. PubMed ID: 21419854
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identifying the translational gap in the evaluation of drug-induced QTc interval prolongation.
    Chain AS; Dubois VF; Danhof M; Sturkenboom MC; Della Pasqua O;
    Br J Clin Pharmacol; 2013 Nov; 76(5):708-24. PubMed ID: 23351036
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs.
    Ollerstam A; Visser SA; Persson AH; Eklund G; Nilsson LB; Forsberg T; Wiklund SJ; Gabrielsson J; Duker G; Al-Saffar A
    J Pharmacol Toxicol Methods; 2006; 53(2):174-83. PubMed ID: 16140023
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis.
    Gotta V; Cools F; van Ammel K; Gallacher DJ; Visser SA; Sannajust F; Morissette P; Danhof M; van der Graaf PH
    Br J Pharmacol; 2015 Sep; 172(17):4364-79. PubMed ID: 26076100
    [TBL] [Abstract][Full Text] [Related]  

  • 7. QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome.
    Chen X; Cass JD; Bradley JA; Dahm CM; Sun Z; Kadyszewski E; Engwall MJ; Zhou J
    Br J Pharmacol; 2005 Nov; 146(6):792-9. PubMed ID: 16158069
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A highly sensitive canine telemetry model for detection of QT interval prolongation: studies with moxifloxacin, haloperidol and MK-499.
    Chaves AA; Zingaro GJ; Yordy MA; Bustard KA; O'Sullivan S; Galijatovic-Idrizbegovic A; Schuck H; Christian DB; Hoe CM; Briscoe RJ
    J Pharmacol Toxicol Methods; 2007; 56(2):103-14. PubMed ID: 17643323
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sensitivity of common marmosets to detect drug-induced QT interval prolongation: moxifloxacin case study.
    Komatsu R; Honda M; Holzgrefe HH; Kubo J; Yamada Y; Isobe T; Kimura K; Itoh T; Tamaoki N; Tabo M
    J Pharmacol Toxicol Methods; 2010; 61(3):271-6. PubMed ID: 20097298
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Application of a probabilistic method for the determination of drug-induced QT prolongation in telemetered cynomolgus monkeys: effects of moxifloxacin.
    Holzgrefe HH; Cavero I; Buchanan LV; Gill MW; Durham SK
    J Pharmacol Toxicol Methods; 2007; 55(3):227-37. PubMed ID: 17097307
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacokinetic-pharmacodynamic modelling of drug-induced QTc interval prolongation in man: prediction from in vitro human ether-à-go-go-related gene binding and functional inhibition assays and conscious dog studies.
    Dubois VF; Casarotto E; Danhof M; Della Pasqua O
    Br J Pharmacol; 2016 Oct; 173(19):2819-32. PubMed ID: 27427789
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cardiovascular monkey telemetry: sensitivity to detect QT interval prolongation.
    Chaves AA; Keller WJ; O'Sullivan S; Williams MA; Fitzgerald LE; McPherson HE; Goykhman D; Ward PD; Hoe CM; Mixson L; Briscoe RJ
    J Pharmacol Toxicol Methods; 2006; 54(2):150-8. PubMed ID: 16679034
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Model-based evaluation of drug-induced QTc prolongation for compounds in early development.
    Dubois VF; Yu H; Danhof M; Della Pasqua O;
    Br J Clin Pharmacol; 2015 Jan; 79(1):148-61. PubMed ID: 25099645
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Preclinical QT safety assessment: cross-species comparisons and human translation from an industry consortium.
    Holzgrefe H; Ferber G; Champeroux P; Gill M; Honda M; Greiter-Wilke A; Baird T; Meyer O; Saulnier M
    J Pharmacol Toxicol Methods; 2014; 69(1):61-101. PubMed ID: 23689033
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans.
    Dubois VF; de Witte WE; Visser SA; Danhof M; Della Pasqua O; ;
    Pharm Res; 2016 Jan; 33(1):40-51. PubMed ID: 26553352
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development.
    Caruso A; Frances N; Meille C; Greiter-Wilke A; Hillebrecht A; Lavé T
    J Pharmacol Toxicol Methods; 2014; 70(1):73-85. PubMed ID: 24879942
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Assessment of drug-induced QT interval prolongation in conscious rabbits.
    Kijtawornrat A; Ozkanlar Y; Keene BW; Roche BM; Hamlin DM; Hamlin RL
    J Pharmacol Toxicol Methods; 2006; 53(2):168-73. PubMed ID: 16290300
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys.
    Haushalter TM; Friedrichs GS; Reynolds DL; Barecki-Roach M; Pastino G; Hayes R; Bass AS
    Br J Pharmacol; 2008 Aug; 154(7):1457-64. PubMed ID: 18604237
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administrations of dofetilide on ventricular repolarization.
    Le Coz F; Funck-Brentano C; Morell T; Ghadanfar MM; Jaillon P
    Clin Pharmacol Ther; 1995 May; 57(5):533-42. PubMed ID: 7768076
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cardiovascular safety assessments in the conscious telemetered dog: utilisation of super-intervals to enhance statistical power.
    Sivarajah A; Collins S; Sutton MR; Regan N; West H; Holbrook M; Edmunds N
    J Pharmacol Toxicol Methods; 2010; 62(1):12-9. PubMed ID: 20570743
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.