These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

390 related articles for article (PubMed ID: 23588311)

  • 1. ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans.
    Zamek-Gliszczynski MJ; Lee CA; Poirier A; Bentz J; Chu X; Ellens H; Ishikawa T; Jamei M; Kalvass JC; Nagar S; Pang KS; Korzekwa K; Swaan PW; Taub ME; Zhao P; Galetin A;
    Clin Pharmacol Ther; 2013 Jul; 94(1):64-79. PubMed ID: 23588311
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.
    Li R; Barton HA; Varma MV
    Clin Pharmacokinet; 2014 Aug; 53(8):659-78. PubMed ID: 25056496
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.
    Feng B; Varma MV; Costales C; Zhang H; Tremaine L
    Expert Opin Drug Discov; 2014 Aug; 9(8):873-90. PubMed ID: 24857286
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Overcoming the shortcomings of the extended-clearance concept: a framework for developing a physiologically-based pharmacokinetic (PBPK) model to select drug candidates involving transporter-mediated clearance.
    Liang X; Lai Y
    Expert Opin Drug Metab Toxicol; 2021 Aug; 17(8):869-886. PubMed ID: 33793347
    [No Abstract]   [Full Text] [Related]  

  • 5. Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.
    Chu X; Korzekwa K; Elsby R; Fenner K; Galetin A; Lai Y; Matsson P; Moss A; Nagar S; Rosania GR; Bai JP; Polli JW; Sugiyama Y; Brouwer KL;
    Clin Pharmacol Ther; 2013 Jul; 94(1):126-41. PubMed ID: 23588320
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Transporter biology in drug approval: regulatory aspects.
    Maeda K; Sugiyama Y
    Mol Aspects Med; 2013; 34(2-3):711-8. PubMed ID: 23506904
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions.
    Chu X; Chan GH; Evers R
    J Pharm Sci; 2017 Sep; 106(9):2357-2367. PubMed ID: 28416420
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches.
    Guo Y; Chu X; Parrott NJ; Brouwer KLR; Hsu V; Nagar S; Matsson P; Sharma P; Snoeys J; Sugiyama Y; Tatosian D; Unadkat JD; Huang SM; Galetin A;
    Clin Pharmacol Ther; 2018 Nov; 104(5):865-889. PubMed ID: 30059145
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.
    Taskar KS; Pilla Reddy V; Burt H; Posada MM; Varma M; Zheng M; Ullah M; Emami Riedmaier A; Umehara KI; Snoeys J; Nakakariya M; Chu X; Beneton M; Chen Y; Huth F; Narayanan R; Mukherjee D; Dixit V; Sugiyama Y; Neuhoff S
    Clin Pharmacol Ther; 2020 May; 107(5):1082-1115. PubMed ID: 31628859
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Impact of hepatic uptake transporters on pharmacokinetics and drug-drug interactions: use of assays and models for decision making in the pharmaceutical industry.
    Soars MG; Webborn PJ; Riley RJ
    Mol Pharm; 2009; 6(6):1662-77. PubMed ID: 19402709
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.
    Zamek-Gliszczynski MJ; Taub ME; Chothe PP; Chu X; Giacomini KM; Kim RB; Ray AS; Stocker SL; Unadkat JD; Wittwer MB; Xia C; Yee SW; Zhang L; Zhang Y;
    Clin Pharmacol Ther; 2018 Nov; 104(5):890-899. PubMed ID: 30091177
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Prediction of pharmacokinetics and drug-drug interactions from in vitro metabolism data.
    Shou M
    Curr Opin Drug Discov Devel; 2005 Jan; 8(1):66-77. PubMed ID: 15679174
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions.
    Langer O
    J Clin Pharmacol; 2016 Jul; 56 Suppl 7():S143-56. PubMed ID: 27385172
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evaluation of New Chemical Entities as Substrates of Liver Transporters in the Pharmaceutical Industry: Response to Regulatory Requirements and Future Steps.
    Okudaira N
    J Pharm Sci; 2017 Sep; 106(9):2251-2256. PubMed ID: 28533120
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model.
    Patilea-Vrana G; Unadkat JD
    Clin Pharmacol Ther; 2016 Nov; 100(5):413-418. PubMed ID: 27448198
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Recent progress in in vivo phenotyping technologies for better prediction of transporter-mediated drug-drug interactions.
    Maeda K
    Drug Metab Pharmacokinet; 2020 Feb; 35(1):76-88. PubMed ID: 31948854
    [TBL] [Abstract][Full Text] [Related]  

  • 17. EUFEPS conference on drug transporters at Copenhagen: integrative approaches in ADME research.
    Meijer DK; Lennernäs H
    Eur J Pharm Sci; 2005 Sep; 26(1):130-43. PubMed ID: 16161216
    [No Abstract]   [Full Text] [Related]  

  • 18. Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.
    Varma MV; El-Kattan AF
    J Clin Pharmacol; 2016 Jul; 56 Suppl 7():S99-S109. PubMed ID: 27385183
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Using positron emission tomography to study transporter-mediated drug-drug interactions in tissues.
    Wulkersdorfer B; Wanek T; Bauer M; Zeitlinger M; Müller M; Langer O
    Clin Pharmacol Ther; 2014 Aug; 96(2):206-13. PubMed ID: 24682030
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rationalizing underprediction of drug clearance from enzyme and transporter kinetic data: from in vitro tools to mechanistic modeling.
    Galetin A
    Methods Mol Biol; 2014; 1113():255-88. PubMed ID: 24523117
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.