106 related articles for article (PubMed ID: 23594041)
1. Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation.
Xu J; Bussiere J; Yie J; Sickmier A; An P; Belouski E; Stanislaus S; Walker KW
Bioconjug Chem; 2013 Jun; 24(6):915-25. PubMed ID: 23594041
[TBL] [Abstract][Full Text] [Related]
2. A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog.
Song L; Zhu Y; Wang H; Belov AA; Niu J; Shi L; Xie Y; Ye C; Li X; Huang Z
Biomaterials; 2014 Jun; 35(19):5206-15. PubMed ID: 24685265
[TBL] [Abstract][Full Text] [Related]
3. One-step production of bioactive proteins through simultaneous PEGylation and refolding.
Niu J; Zhu Y; Song L; Xie Y; Zhang Y; Wang H; Li X; Liu B; Cai L; Huang Z
Bioconjug Chem; 2014 Jan; 25(1):63-71. PubMed ID: 24341776
[TBL] [Abstract][Full Text] [Related]
4. A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol.
Huang Z; Wang H; Lu M; Sun C; Wu X; Tan Y; Ye C; Zhu G; Wang X; Cai L; Li X
PLoS One; 2011; 6(6):e20669. PubMed ID: 21673953
[TBL] [Abstract][Full Text] [Related]
5. FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents.
Mu J; Pinkstaff J; Li Z; Skidmore L; Li N; Myler H; Dallas-Yang Q; Putnam AM; Yao J; Bussell S; Wu M; Norman TC; Rodriguez CG; Kimmel B; Metzger JM; Manibusan A; Lee D; Zaller DM; Zhang BB; DiMarchi RD; Berger JP; Axelrod DW
Diabetes; 2012 Feb; 61(2):505-12. PubMed ID: 22210323
[TBL] [Abstract][Full Text] [Related]
6. Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody.
Huang J; Ishino T; Chen G; Rolzin P; Osothprarop TF; Retting K; Li L; Jin P; Matin MJ; Huyghe B; Talukdar S; Bradshaw CW; Palanki M; Violand BN; Woodnutt G; Lappe RW; Ogilvie K; Levin N
J Pharmacol Exp Ther; 2013 Aug; 346(2):270-80. PubMed ID: 23720456
[TBL] [Abstract][Full Text] [Related]
7. Enhanced protection of modified human acidic fibroblast growth factor with polyethylene glycol against ischemia/reperfusion-induced retinal damage in rats.
Huang Z; Zheng Q; Wu X; Su Z; Xu H; Tan Y; Feng W; Li X; Cai L
Toxicol Lett; 2007 Apr; 170(2):146-56. PubMed ID: 17416472
[TBL] [Abstract][Full Text] [Related]
8. Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation.
Basu A; Yang K; Wang M; Liu S; Chintala R; Palm T; Zhao H; Peng P; Wu D; Zhang Z; Hua J; Hsieh MC; Zhou J; Petti G; Li X; Janjua A; Mendez M; Liu J; Longley C; Zhang Z; Mehlig M; Borowski V; Viswanathan M; Filpula D
Bioconjug Chem; 2006; 17(3):618-30. PubMed ID: 16704199
[TBL] [Abstract][Full Text] [Related]
9. N-terminal mono-PEGylation of growth hormone antagonist: correlation of PEG size and pharmacodynamic behavior.
Wu L; Ho SV; Wang W; Gao J; Zhang G; Su Z; Hu T
Int J Pharm; 2013 Sep; 453(2):533-40. PubMed ID: 23796830
[TBL] [Abstract][Full Text] [Related]
10. Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency.
Yoshioka Y; Tsutsumi Y; Ikemizu S; Yamamoto Y; Shibata H; Nishibata T; Mukai Y; Okamoto T; Taniai M; Kawamura M; Abe Y; Nakagawa S; Nagata S; Yamagata Y; Mayumi T
Biochem Biophys Res Commun; 2004 Mar; 315(4):808-14. PubMed ID: 14985084
[TBL] [Abstract][Full Text] [Related]
11. Chemical and enzymatic site specific PEGylation of hGH.
da Silva Freitas D; Mero A; Pasut G
Bioconjug Chem; 2013 Mar; 24(3):456-63. PubMed ID: 23432141
[TBL] [Abstract][Full Text] [Related]
12. High molecular weight polyethylene glycol cellular distribution and PEG-associated cytoplasmic vacuolation is molecular weight dependent and does not require conjugation to proteins.
Rudmann DG; Alston JT; Hanson JC; Heidel S
Toxicol Pathol; 2013; 41(7):970-83. PubMed ID: 23788571
[TBL] [Abstract][Full Text] [Related]
13. Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity.
Yin J; Bao L; Tian H; Wang Q; Gao X; Yao W
Br J Pharmacol; 2016 Jul; 173(14):2208-23. PubMed ID: 27339749
[TBL] [Abstract][Full Text] [Related]
14. Phenyl amide linker improves the pharmacokinetics and pharmacodynamics of N-terminally mono-PEGylated human growth hormone.
Wu L; Ji S; Shen L; Hu T
Mol Pharm; 2014 Sep; 11(9):3080-9. PubMed ID: 25115329
[TBL] [Abstract][Full Text] [Related]
15. Enhanced circulating half-life and antitumor activity of a site-specific pegylated interferon-alpha protein therapeutic.
Bell SJ; Fam CM; Chlipala EA; Carlson SJ; Lee JI; Rosendahl MS; Doherty DH; Cox GN
Bioconjug Chem; 2008 Jan; 19(1):299-305. PubMed ID: 18020402
[TBL] [Abstract][Full Text] [Related]
16. Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation.
Li S; Yang Z; Sun X; Tan Y; Yagi S; Hoffman RM
Anal Biochem; 2004 Jul; 330(2):264-71. PubMed ID: 15203332
[TBL] [Abstract][Full Text] [Related]
17. Polyethylene glycol (PEG)-modified granulocyte-macrophage colony-stimulating factor (GM-CSF) with conserved biological activity.
Malik F; Delgado C; Knüsli C; Irvine AE; Fisher D; Francis GE
Exp Hematol; 1992 Sep; 20(8):1028-35. PubMed ID: 1505637
[TBL] [Abstract][Full Text] [Related]
18. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21.
Müller TD; Sullivan LM; Habegger K; Yi CX; Kabra D; Grant E; Ottaway N; Krishna R; Holland J; Hembree J; Perez-Tilve D; Pfluger PT; DeGuzman MJ; Siladi ME; Kraynov VS; Axelrod DW; DiMarchi R; Pinkstaff JK; Tschöp MH
J Pept Sci; 2012 Jun; 18(6):383-93. PubMed ID: 22565812
[TBL] [Abstract][Full Text] [Related]
19. PEGylation and its impact on the design of new protein-based medicines.
Ginn C; Khalili H; Lever R; Brocchini S
Future Med Chem; 2014; 6(16):1829-46. PubMed ID: 25407370
[TBL] [Abstract][Full Text] [Related]
20. Site-specific PEGylation of bone morphogenetic protein-2 cysteine analogues.
Hu J; Duppatla V; Harth S; Schmitz W; Sebald W
Bioconjug Chem; 2010 Oct; 21(10):1762-72. PubMed ID: 20886828
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]